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Isolation and characterization of genes involved in the abnormalities of mitosis and nuclear morphology found in myelodysplastic syndromes.

Research Project

Project/Area Number 22659181
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionHiroshima University

Principal Investigator

INABA Toshiya  広島大学, 原爆放射線医科学研究所, 教授 (60281292)

Co-Investigator(Kenkyū-buntansha) MATSUI Hirotaka  広島大学, 原爆放射線医科学研究所, 准教授 (60379849)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,140,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsMDS / エピゲノム制御 / 骨髄異形成症候群 / 7番染色体欠損 / 発がん抑制遺伝子 / 遺伝子欠損マウス / エンドソーム代謝 / 骨髄性白血病 / 分裂期異常
Research Abstract

The aim of this study is isolation and characterization of genes involved in the abnormalities of mitosis and nuclear morphology frequently found in myelodysplastic syndromes(MDS). We identified Miki and CG-NAP as crucial members of the transportation system for pericentriolar materials(Mol. Cell), and dynactin-3 that maintains centrosome function in the metaphase(JBC).

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2012 2011 2010 Other

All Journal Article (26 results) (of which Peer Reviewed: 20 results) Presentation (17 results)

  • [Journal Article] (2012) A modified system for analyzing ionizing radiation-induced chromosome abnormalities2012

    • Author(s)
      Shi, L., Fujioka, K., Sun, J., Kinomura, A., Inaba, T., Ikura, T., Ohtaki, M., Yoshida, M., Kodama, Y., Livingston, G. K., Kamiya, K., and Tashiro, S
    • Journal Title

      Radiat Res

      Volume: 177 Pages: 533-538

    • Related Report
      2011 Final Research Report
  • [Journal Article] (2011) Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma2011

    • Author(s)
      Jin, L., Tabe, Y., Kimura, S., Zhou, Y., Kuroda, J., Asou, H., Inaba, T., Konopleva, M., Andreeff, M., and Miida, T.
    • Journal Title

      Br. J. Cancer

      Volume: 104 Pages: 91-100

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2011) The dynactin complex maintains the integrity of metaphasic centrosomes to ensure transition to anaphase2011

    • Author(s)
      Ozaki, Y., Matsui, H., Nagamachi, A., Asou, H., Aki, D., and Inaba, T.
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 5589-5598

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2011) TheSamd9L Gene : Transcriptional Regulation and Tissue-Specific Expression in Mouse Development2011

    • Author(s)
      Jiang, Q., Quaynor, B., Sun, A., Li, Q., Matsui, H., Honda, H., Inaba, T., Sprecher, E., ans Uitto, J.
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 1428-1434

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2011) Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo.2011

    • Author(s)
      Hiraga, N., Imamura, M., Abe, H., Hayes, C. N., Kono, T., Onishi, M., Tsuge, M., Takahashi, S., Ochi, H., Iwao, E., Kamiya, N., Yamada, I., Tateno, C., Yoshizato, K., Matsui, H., Kanai, A., Inaba, T., Tanaka, S., and Chayama, K.
    • Journal Title

      Hepatology

      Volume: 54 Pages: 781-788

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2011) Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/ Abl2011

    • Author(s)
      Seo, S., Nakamoto, T., Takeshita, M., Lu, J., Sato, T., Suzuki, T., Kamikubo, Y., Ichikawa, M., Noda, M., Ogawa, S., Honda, H., Oda, H. and Kurokawa, M.
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 2109-2117

    • Related Report
      2011 Final Research Report
  • [Journal Article] Rapidemergence of telaprevir resistanthepatitis C virus strain from wildtypeclone in vivo2011

    • Author(s)
      Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, TakahashiS, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, KanaiA, Inaba T, Tanaka S, Chayama K
    • Journal Title

      Hepatology

      Volume: 54 Issue: 3 Pages: 781-788

    • DOI

      10.1002/hep.24460

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Samd9L gene : transcriptional regulation and tissue-specific expression in mouse development2011

    • Author(s)
      Jiang Q., et al
    • Journal Title

      J Invest Dermatol

      Volume: 131 Issue: 7 Pages: 1428-1434

    • DOI

      10.1038/jid.2011.61

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma2011

    • Author(s)
      Jin L., et al
    • Journal Title

      Br.J.Cancer

      Volume: 104 Pages: 91-100

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dynactin complex maintains the integrity of metaphasic centrosomes to ensure transition to anaphase2011

    • Author(s)
      Ozaki, Y., et al
    • Journal Title

      J.Biol.Chem

      Volume: 286 Pages: 5589-5598

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma.2011

    • Author(s)
      Jin, L., et al
    • Journal Title

      Br.J.Cancer

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dynactin complex maintains the integrity of metaphasic centrosomes to ensure transition to anaphase.2011

    • Author(s)
      Ozaki, Y., et al
    • Journal Title

      J.Biol.Chem

      Volume: 286 Pages: 5589-5598

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (2010) Upregulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17 ; 19)-positive leukemia cells2010

    • Author(s)
      Okuya, M., Kurosawa, H., Kikuchi, J., Furukawa, Y., Matsui, H., Aki, D., Matsunaga, T., Inukai, T., Goto, H., Altura, R. A., Sugita, K., Arisaka, O., Look, A. T., and Inaba, T
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 1850-1860

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2010) Identification of Zfp521/ ZNF521 as acooperative gene for E2A-HLF to develop acute B-lineage leukemia2010

    • Author(s)
      Yamasaki, N., Miyazaki, K., Nagamachi, A., Koller, R., Oda, H., Miyazaki, M., Sasaki, T., Honda, Zi., Wolff, L., Inaba, T., and Honda, H.
    • Journal Title

      Oncogene

      Volume: 29 Pages: 1963-1975

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2010) Specific induction of CD33 expression by E2A-HLF : the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor2010

    • Author(s)
      Akahane, K., Inukai, T., Inaba, T., Kurosawa, H., Look, A. T., Kiyokawa, N., Fujimoto, J., Goto, H., Endo, M., Zhang, X., Hirose, K., Kuroda, I., Honna, H., Kagami, J., Goi, K., Nakazawa, S., and Sugita K.
    • Journal Title

      Leukemia

      Volume: 24 Pages: 865-869

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2010) Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17 ; 19)2010

    • Author(s)
      Hirose, K., Inukai, T., Kikuchi, J., Furukawa, Y., Ikawa, T., Kawamoto, H., Oram, S. H., Gottgens, B., Kiyokawa, N., Miyagawa, Y., Okita, H., Akahane, K., Zhang, X., Kuroda, I., Honna, H., Kagami, K., Goi, K., Kurosawa, H., Look, A. T., Matsui, H., Inaba,
    • Journal Title

      Blood

      Volume: 116 Pages: 962-970

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2010) A5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model2010

    • Author(s)
      Nagamachi, A., Htun, P. W., Ma, F., Miyazaki, K., Yamasaki, N., Kanno, M., Inaba, T., Honda, Z. I., Okuda, T., Oda, H., Tsuji, K., and Honda, H.
    • Journal Title

      Dev. Biol

      Volume: 345 Pages: 226-236

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells.2010

    • Author(s)
      Okuya, M., et al
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 1850-1860

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Zfp521/ZNF521 as acooperative gene for E2A-HLF to develop acute B-lineage leukemia.2010

    • Author(s)
      Yamasaki, N., et al
    • Journal Title

      Oncogene

      Volume: 29 Pages: 1963-1975

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific induction of CD33 expression by E2A-HLF : the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.2010

    • Author(s)
      Akahane, K., et al
    • Journal Title

      Leukemia

      Volume: 24 Pages: 865-869

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).2010

    • Author(s)
      Hirose, K., et al
    • Journal Title

      Blood

      Volume: 116 Pages: 962-970

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.2010

    • Author(s)
      Nagamachi, A., et al
    • Journal Title

      Dev Biol.

      Volume: 345 Pages: 226-236

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenic Fusion E2A-HLF Sensitizes t(17 ; 19)-positive Acute Lymphoblastic Leukemia toTRAIL-Mediated Apoptosis by Upregulating the Expression of Death Receptors

    • Author(s)
      Zhang, X., Inukai, T., Hirose, K., Akahane, K., Kuroda, I., Honna-Oshiro, H., Kagami, K., Goi, K., Nakamura, K., Kobayashi, M., Endo, M., Yagita, H., Kurosawa, H., Look, A. T., Honda, H., Inaba, T., Nakazawa, S., and Sugita, K.
    • Journal Title

      Leukemia

      Volume: in press

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mouse Samd9l is not a functional paralogue of the human SAMD9, the gene mutated in normophosphataemic familial tumoral calcinosis

    • Author(s)
      Li, Q., Guo, H., Matsui, H., Honda, H., Inaba, T., Sundberg, J. P., Sprecher, E., and Uitto, J
    • Journal Title

      Exp. Dermatol

      Volume: in press

    • Related Report
      2011 Final Research Report
  • [Journal Article] EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms

    • Author(s)
      Ueda, T., Sanada, M., Matsui, H., Yamasaki, N., Honda, Zi., Shih, L. Y., Mori, H., Inaba, T., Ogawa, S.
    • Journal Title

      Leukemia

      Volume: in press

    • Related Report
      2011 Final Research Report
  • [Journal Article] Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation

    • Author(s)
      Ozaki, Y., Matsui, H., Asou, H., Nagamachi, A., Aki, D., Honda, H., Yasunaga, S., Takihara, Y., Yamamoto, T., Izumi, S., Ohsugi, M., and Inaba, T.
    • Journal Title

      Mol. Cell

      Volume: in press

    • Related Report
      2011 Final Research Report
  • [Presentation] a candidate-7/ 7q-responsible gene product, downregulates cytokine signals by facilitating formation of early endosome2011

    • Author(s)
      Matsui, H. Titan(Samd9L)
    • Organizer
      第53回アメリカ血液学会
    • Place of Presentation
      サンディエゴ米国
    • Year and Date
      2011-12-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Titan (Samd9L), a candidate-7/7q-responsible gene product, downregulates cytokine signals by facilitating formation of early endosome2011

    • Author(s)
      Matsui, H.
    • Organizer
      第53回アメリカ血液学会
    • Place of Presentation
      サンディエゴ米国
    • Year and Date
      2011-12-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of epigeneticalterations by 5-Azacitidine that induces erythroid differentiation using a next generation sequencer2011

    • Author(s)
      松井啓隆
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of epigenetic alterations by 5-Azacitidine that induces erythroid differentiation using a next generation sequencer2011

    • Author(s)
      松井啓隆
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of epigenetic changes by 5-Azacitidine that induces erythroid differentiation using a next generation sequencer2011

    • Author(s)
      松井啓隆
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Development of myeloid neoplasia in mice deficient for endosome fusion facilitator(eff)-2gene that mimic human-7/ 7q-2011

    • Author(s)
      松井啓隆
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of myeloid neoplasia in mice deficient for endosome fusion facilitator(eff)-2gene mimic human-7/7q-2011

    • Author(s)
      松井啓隆
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] (AstraZeneca, Dept Dev Biol) Titan(Samd9L), a candidate-7/ 7q responsible gene product, downregulates cytokine signals by facilitating formation of early endosomes.2010

    • Author(s)
      Matsui H, Nagamachi A, Ozaki Y, AsouH, Honda H, Inaba T.
    • Organizer
      第52回米国血液学会総会
    • Place of Presentation
      米国オーランド
    • Year and Date
      2010-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Titan (Samd9L), a candidate -7/7q- responsible gene product, downregulates cytokine signals by facilitating formation of early endosomes.2010

    • Author(s)
      Matsui, H., et al
    • Organizer
      第52回米国血液学会総会
    • Place of Presentation
      米国、オーランド
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 7番染色体長腕欠損による白血病発症メカニズム:責任遺伝子の単離と機能解析2010

    • Author(s)
      松井啓隆
    • Organizer
      第53回放射線影響学会大会(招待講演)
    • Place of Presentation
      京都
    • Year and Date
      2010-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] (AstraZeneca,疾患モデル解析) Titan(Samd9L), a candidate 7qresponsiblegene product, promotesdegradation of cytokine receptors2010

    • Author(s)
      松井啓隆, 長町安希子, 尾崎佑子, 麻生博也, 本田浩章, 稲葉俊哉
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Titan (Samd9L), a candidate 7q- responsible gene product, promotes degradation of cytokine receptors.2010

    • Author(s)
      Matsui, H., et al
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] (AstraZeneca,疾患モデル解析) Titan(Samd9L), a candidate 7qresponsiblegene product, promotesdegradation of cytokine receptors2010

    • Author(s)
      松井啓隆, 長町安希子, 尾崎佑子, 麻生博也, 本田浩章, 稲葉俊哉
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Titan (Samd9L), a candidate -7/7q- responsible gene product, promotes degradation of cytokine receptors.2010

    • Author(s)
      Matsui, H., et al
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] (La Jolla Inst for Allerg & Immunol, AstraZeneca,疾患モデル解析)稲葉俊哉7q欠失責任遺伝子候補Titanによるサイトカイン受容体分解制御2010

    • Author(s)
      松井啓隆, 長町安希子, 尾崎佑子, 安藝大輔, 麻生博也, 本田浩章, 稲葉俊哉
    • Organizer
      第51回原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2010-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] (La Jolla Inst for Allerg & Immunol, AstraZeneca,疾患モデル解析,東京女子医大病理) 7q-欠損白血病におけるEvil, Fbxl10の関与2010

    • Author(s)
      長町安希子, 松井啓隆, 安藝大輔, 尾崎佑子, 麻生博也, 山崎憲政, 小田秀明, 稲葉俊哉, 本田浩章
    • Organizer
      第51回原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2010-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] (La Jolla Inst for Allerg & Immunol)放射線誘発白血病の関連遺伝子Miki/ CG-NAPの分裂期中心体における機能2010

    • Author(s)
      尾崎佑子, 松井啓隆, 安藝大輔, 長町安希子, 稲葉俊哉
    • Organizer
      第51回原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2010-06-06
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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