Clinical and pathophysiological significance of novel identified anti-IFIH1/MDA5 autoantibody in amyopathic dermatomyositis
| Project/Area Number |
22659185
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
NAKASHIMA Ran 京都大学医学部附属病院, 免疫・膠原病内科, 医員
HOSONO Yuji 京都大学, 大学院・医学研究科内科学講座臨床免疫学, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | IFIH1 / MDA5 / CADM-140 / 自己抗体 / 皮膚筋炎 / 間質性肺炎 / サイトカイン / HLA / ADM |
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| Research Abstract |
A disease-specific autoantibody, termed anti-CADM-140 antibody, is found in patients with amyopathic dermatomyositis accompanied with lethal acute interstitial pneumonia. We identified that the target autoantigen recognized by anti-CADM-140 antibody was IFIH1/MDA5, a viral RNA receptor in cytoplasm. The patients with anti-CADM-140 antibody revealed higher level of serum ferritin as well as IL-6, IL-10, IL-18 and M-CSF than antibody-negative dermatomyositis patients, suggesting the macrophage activating state. The intensive immunosuppressive therapy(high-dose glucocorticoids, cyclosporine and intravenous cyclophosphamide pulse) appeared to improve a life prognosis of antibody-positive patients when compared with the conventional step-up therapy.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Detection of antisynthetase syndrome in patients with idiopathic interstitial pneumonias2011
Author(s)
Watanabe K, Handa T, Tanizawa K, Hosono Y, Taguchi Y, Noma S, Kobashi Y, Kubo T, Aihara K, Chin K, Nagai S, Mimori T, Mishima M
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Journal Title
Respir Med
Volume: 105(8)
Issue: 8
Pages: 1238-47
DOI
Related Report
Peer Reviewed
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[Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen recognized by anti-CADM-140 antibody2010
Author(s)
Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T
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Journal Title
Rheumatology(Oxford)
Volume: 49(3)
Issue: 3
Pages: 433-40
DOI
Related Report
Peer Reviewed
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[Presentation] 自己抗体抗アミノアシルtRNA合成酵素抗体を検出するための新規ELISAの開発2011
Author(s)
中嶋蘭, 井村嘉孝, 瀬戸美苗, 村上昭弘, 小林志緒, 細野祐司, 湯川尚一郎, 吉藤元, 川端大介, 大村浩一郎, 臼井崇, 藤井隆夫, 三森経世
Organizer
第39回日本臨床免疫学会
Place of Presentation
東京
Related Report
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[Presentation] A new ELISA system for detecting autoantibodies to aminoacyl-tRNA synthetases : Usefulness in myositis and interstitial pneumonia2010
Author(s)
Nakashima R, Imura Y, Seto M, Murakami A, Kobayashi S, Hosono Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Fujii T, Mimori T
Organizer
2010American College of Rheumatology
Place of Presentation
Atlanta
Related Report
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