| Project/Area Number |
22659187
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 上皮細胞 / 鼻炎 / アレルギー / サイトカイン / 好塩基球 / アレルゲン |
|---|
| Research Abstract |
Allergic rhinitis often develop even in people without atopic disposition during pollen season as well as people with a predisposition to atopy. Divided into two types, it was named "atopic allergic rhinitis" and "sudden-onset allergic rhinitis", respectively. In this study, we established above two types of mouse model of ragweed pollen-specific allergic rhinitis, and analyzed the mechanism of its onset. As a result, we revealed that both pollen grains-deriven IL-33 from nasal mucosa epithelial cells and the FcεR1 positive cells(mast cells and basophils) play an important role in the pathogenesis of pollen-specific allergic rhinitis.
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