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CD1/lipid immunity-based vaccines against AIDS

Research Project

Project/Area Number 22659188
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Infectious disease medicine
Research InstitutionKyoto University

Principal Investigator

SUGITA Masahiko  京都大学, ウイルス研究所, 教授 (80333532)

Co-Investigator(Kenkyū-buntansha) IGARASHI Tatsuhiko  京都大学, ウイルス研究所, 教授 (90467431)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,370,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Keywords感染症防御学 / リポペプチド / エイズ / ワクチン / CD1
Research Abstract

Effective protein vaccines against infection with human immunodeficiency virus remain to be established. The difficulties arise from the frequent escape mutations, and thus, identification of T cell epitopes that admit of no arbitrary mutations is crucial. We have identified cytotoxic T cell responses to myristoylated Nef peptides(lipopeptides) both in cell culture and in the monkey model of human AIDS. Because the protein myristoylation occurs in highly conserved amino acid sequences and is critical for virulence, the present study underscored the possibility that lipopeptides could be an ideal target for anti-AIDS vaccines.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (2 results)

  • [Journal Article] Cutting edge : T cells monitor N-myristoylation of the Nef protein in simian immunodeficiency virus-infected monkeys2011

    • Author(s)
      Morita D, Igarashi T, Horiike M, Mori N, Sugita M.
    • Journal Title

      J. Immunol

      Volume: 187(2) Pages: 608-612

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cutting edge : T cells monitor N-myristoylation of the Nef protein in simian immunodeficiency virus-infected monkeys2011

    • Author(s)
      Morita D, et al
    • Journal Title

      Journal of Immunology

      Volume: 187 Pages: 608-612

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Nef蛋白質のミリスチン酸修飾をモニターする新たな免疫システム2011

    • Author(s)
      森田大輔、五十嵐樹彦、堀池麻理子、森直樹、杉田昌彦
    • Organizer
      第25回日本エイズ学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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