Development of evaluation method of drug safety for children using cultured cells and tandem mass spectrometry
| Project/Area Number |
22659195
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
HASEGAWA Yuki 島根大学, 医学部, 助教 (00362921)
KOBAYASHI Hironori 島根大学, 医学部, 助教 (70397868)
MUSHIMOTO Yuichi 島根大学, 医学部, 助教 (90467712)
PUREVSUREN Jamiyan 島根大学, 医学部, 外国人特別研究員
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
|---|
| Keywords | 脂肪酸代謝異常 / インフルエンザ脳症 / 薬剤安全性 / β酸化能 / ベザフィブレート / 急性脳症 |
|---|
| Research Abstract |
There are some drugs which may occasionally toxic for children, despite non-toxic for adults. We use a method, in vitro probe acylcarnitine(IVP) assay, using cultured fibroblasts and tandem mass spectrometry(MS/MS) to evaluate fatty acid oxidation(FAO) capacity and toxicity of drugs. Cells from various FAO disorders(medium-to long-chain disorders) were used, and the following results were obtained : Aspirin(antipyretic), and valproic acid(anti-epileptic drug) potentially caused some inhibition of FAO in cells from impaired FAO patients. Bezafibrate(hypolipidemic drug) significantly improved FAO in cells from FAO disorders. Bezafibrate can be a new treatment option for FAO disorders.
|
Report
(3 results)
Research Products
(37 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] A hypolipidemic drug, bezafibrate, can be a new treatment option for mitochondrial fatty acid oxidation disorders2011
Author(s)
Yamaguchi S, Li H, Purevsuren J, Mushimoto Y, Kobayashi H, Hasegawa Y, Fukao T, Fukuda S
Organizer
The 7th Congress of Asian Society for Pediatric Research
Place of Presentation
Colorado Convention Center(Denver, USA)
Year and Date
2011-04-30
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
