| Project/Area Number |
22659205
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Okayama University |
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Principal Investigator |
IWATSUKI Keiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (80126797)
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| Co-Investigator(Kenkyū-buntansha) |
AOYAMA Yumi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90291393)
SHIRAFUJI Yoshinori 岡山大学, 岡山大学病院, 助教 (90423285)
FUJII Kazuyasu 岡山大学, 岡山大学病院, 助教 (70452571)
MORIZANA Shin 岡山大学, 岡山大学病院, 助教 (80423333)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | ヒト乳頭腫ウイルス / 伝染性軟属腫 / 樹状細胞 / TSLP / 日光角化症 / Bowen病 / 伝染性軟属腫ウイルス / Th2 / リモデリング / ウイルス / 乳頭腫 / 腫瘍免疫 / ケモカイン / 免疫微小環境 / 接着因子 |
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| Research Abstract |
Dendritic cell(DC) subsets and regulatory mechanisms of host immune responses were studied in human papilloma virus(HPV)-and molluscum contagiosum virus(MCV)-associated warty lesions, Bowen disease, and various epithelial neoplasms. The depletion of Langerin+ DCs(LCs) was obvious in the non-inflammatory HPV-warts, MC, and HPV-Bowen. The lesional epidermis revealed diminished MIP-3αexpression and irregular distribution of E-cadherin. TSLP(thymic stromal lymphopoietin) was highly expressed in HPV-warts and solar keratosis, while a few MCV+ cells were positive for TSLP in MC. MCV-encoded immunoregulatory molecules such as MCV148 and MCV159 were expressed in MC. MIP-3αexpression is up-regulated in inflammatory warts, with the subsequent recruitment of various DC subsets and CD8+ cells. TSLP expression might be associated with immune suppression and Th2 type inflammation in HPV-warts, while MCV-encoded molecules possess a pivotal role in the persistence of MC.
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