| Project/Area Number |
22659210
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAWA Tatsuya 金沢大学, 附属病院, 講師 (10334773)
MURAKAMI Masako 金沢大学, 医学系, 助教 (20324072)
KIKUCHI Mitsuru 金沢大学, 子どものこころ発達研究センター, 特任准教授 (00377384)
UEDA Fumiaki 金沢大学, 附属病院, 講師 (80293356)
SEKIHARA Kensuke 首都大学東京, システムデザイン研究科, 教授 (40326020)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 脳波 / 脳磁図 / 認知機能 / 統合失調症 / オシレーション / 陽性症状 / 陰性症状 / 解体症状 |
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| Research Abstract |
Functional connectivities among cerebral cortical areas wereassessed by electroencephalography and magnetoencephalography in patients with schizophrenia. Drug-naive and first-episode patients exhibited reduced synchronizations of neural activities across global cortical areas. This reduction was most prominent betweenfrontal regions and other cortical areas. Amelioration of symptoms by antipsychotics was positively correlated with the improvement of the global synchronizations. Chronic patients, after the long-term treatments, showed increased coherences among cortical areas. Antipsychotic treatment appeared to have an effect to enhance the cortical synchronization.
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