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Urine metabolomics analysis for autistic spectrum disorder

Research Project

Project/Area Number 22659211
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

MINABE Yoshio  金沢大学, 医学系, 教授 (60181947)

Co-Investigator(Kenkyū-buntansha) MUNESUE Toshio  金沢大学, 子どものこころの発達研究センター, 特任教授 (50293353)
KIKUCHI Mitsuru  金沢大学, 子どものこころの発達研究センター, 特任准教授 (00377384)
MATSUZAKI Hideo  浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00334970)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords児童・思春期精神医学 / メタボローム解析 / 尿メタボローム / 脂肪酸 / 広汎性発達障害 / 就学前児童 / 脳磁図計 / ガスクロマトグラフ質量分析法 / ガスクロマトグラフ量分析法
Research Abstract

Because of its characteristics and simple non-invasive methods of collection, urine is particularly suited for metabolomic analysis even in young children. We explore urine fatty acid metabolic substance as a biomarker for autism spectrum disorder. In 32 ASD children and 24 typically developing(TD) young children(3-7 years old), 7 fatty acid metabolic substances(i. e., myristic acid, palmitic acid, linoleic acid, oleic acid, stearic acid, arachidic acid, behenic acid) in urine were quantified using gas chromatography. mass spectrometry. As a result, there were no significant differences in these concentrations between ASD and TD children. In addition, there were no significant correlations between cognitive performances and these concentrations.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (55 results)

All 2012 2011 2010 Other

All Journal Article (25 results) (of which Peer Reviewed: 23 results) Presentation (23 results) Book (2 results) Remarks (5 results)

  • [Journal Article] Spatiotemporal frequency characteristics of cerebral oscillations during the perception of fundamental frequency contour changes in one-syllable intonation2012

    • Author(s)
      Ueno S, Okumura E, Remijn GB, YoshimuraY, Kikuchi M, Shitamichi K, Nagao K, Mochiduki M, Haruta Y, Hayashi N, Munesue T, Tsubokawa T, Oi M, NakataniH, Higashida H, Minabe Y
    • Journal Title

      Neurosci Lett

      Volume: 515(2) Pages: 141-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Language performance and auditory evoked fields in 2-to 5-year-old children2012

    • Author(s)
      Yoshimura Y, Kikuchi M, Shitamichi K, Ueno S, Remijn GB, Haruta Y, Oi M, Munesue T, Tsubokawa T, Higashida H, Minabe Y
    • Journal Title

      Eur J Neurosci

      Volume: 35(4) Pages: 644-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Algorithm for estimation of brain structural location from head surface shape in young children2012

    • Author(s)
      Hayashi N, Kikuchi M, Sanada S, Minabe Y, Miyati T, Hachiman Y, Arishita T, Iida H, Matsui O
    • Journal Title

      Neuroreport

      Volume: 23(5) Pages: 299-303

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Language performance and auditory evoked fields in 2- to 5-year-old children2012

    • Author(s)
      Yoshimura, Y., Kikuchi, M., Shitamichi, K., Ueno, S., Remijn, G.B., et al
    • Journal Title

      European Journal of Neuroscience

      Volume: 35 Issue: 4 Pages: 644-650

    • DOI

      10.1111/j.1460-9568.2012.07998.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Algorithm for estimation of brain structural location from head surface shape in young children2012

    • Author(s)
      Hayashi N., et al
    • Journal Title

      NeuroReports

      Volume: 28 Issue: 5 Pages: 299-303

    • DOI

      10.1097/wnr.0b013e3283511de0

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lateralized theta wave connectivity and language performance in 2-to 5-year-old children2011

    • Author(s)
      Kikuchi M, Shitamichi K, Yoshimura Y, Ueno S, Remijn GB, Hirosawa T, MunesueT, Tsubokawa T, Haruta Y, Oi M, Higashida H, Minabe Y
    • Journal Title

      J Neurosci

      Volume: 31(42) Pages: 14984-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD38 gene knockout juvenile mice : a model of oxytocin signal defects in autism2011

    • Author(s)
      Higashida H, Yokoyama S, Munesue T, Kikuchi M, Minabe Y, Lopatina O
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 34(9) Pages: 1369-72

    • NAID

      130001872426

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging2011

    • Author(s)
      Kikuchi M, Hirosawa T, Yokokura M, YagiS, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi Y
    • Journal Title

      J Neurosci

      Volume: 31(31) Pages: 11193-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frontal areas contribute to reduced global coordination of resting-state gamma activities in drug-naive patients with schizophrenia2011

    • Author(s)
      Kikuchi M, Hashimoto T, Nagasawa T, Hirosawa T, Minabe Y, Yoshimura M, Strik W, Dierks T, Koenig T
    • Journal Title

      Schizophr Res

      Volume: 130(1-3) Pages: 187-94

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] EEG microstate analysis in drug-naive patients with panic disorder2011

    • Author(s)
      Kikuchi M, Koenig T, Munesue T, Hanaoka A, Strik W, Dierks T, Koshino Y, MinabeY
    • Journal Title

      PLoS One

      Volume: 6(7)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time slip' phenomenon in adolescents and adults with autism spectrum disorders : Case series2011

    • Author(s)
      Tochimoto S, Kurata K, Munesue T
    • Journal Title

      Psychiatry Clin Neurosci

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic responses to visual stimuli in cortex of adults and 3-to 4-year-old children2011

    • Author(s)
      Remijn GB, Kikuchi M, Yoshimura Y, Shitamichi K, Ueno S, Nagao K, MunesueT, Kojima H, Minabe Y
    • Journal Title

      Brain Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011

    • Author(s)
      Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
    • Journal Title

      Arch Gen Psychiatry

      Volume: 68(3) Pages: 306-13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lateralized theta wave connectivity and language performance in 2-to 5-year-old children2011

    • Author(s)
      Kikuchi, M
    • Journal Title

      J Neurosci

      Volume: Vol.31 Issue: 42 Pages: 14984-14988

    • DOI

      10.1523/jneurosci.2785-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging2011

    • Author(s)
      Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi Y
    • Journal Title

      Neurosci

      Volume: 31 Issue: 31 Pages: 11193-9

    • DOI

      10.1523/jneurosci.2535-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic responses to visual stimuli in cortex of adults and 3-to 4-year-old children2011

    • Author(s)
      Remijn, G.B., et al.
    • Journal Title

      Brain Research

      Volume: 1383 Pages: 242-251

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin signal and social behaviour : comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice2010

    • Author(s)
      Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, MunesueT, Minabe Y, Kikuchi M, Ono Y, Korshunova N, Salmina AB
    • Journal Title

      J Neuroendocrinol

      Volume: 22(5) Pages: 373-9

    • NAID

      120002561624

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H
    • Journal Title

      Neurosci Res

      Volume: 67(2) Pages: 181-91

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 青年期双極性障害と自閉症スペクトラム障害との併存、そしてその薬物療法2010

    • Author(s)
      棟居俊夫
    • Journal Title

      臨床精神薬理

      Volume: 13巻 Pages: 910-919

    • Related Report
      2011 Final Research Report
  • [Journal Article] Smaller insula andinferior frontal volumes in youngadults with pervasive developmentaldisorders2010

    • Author(s)
      Kosaka H, Omori M, Munesue T, Ishitobi M, Matsumura Y, Takahashi T, Narita K, Murata T, Saito DN, Uchiyama H, Morita T, Kikuchi M, Mizukami K, Okazawa H, Sadato N, Wada Y
    • Journal Title

      Neuroimage

      Volume: 50(4) Pages: 1357-63

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nurovascular coupling in the human somatosensory cortex : a single trial study2010

    • Author(s)
      Kikuchi M, Shitamichi K, Ueno S, Yoshimura Y, Remijn BG, Nagao K, Munesue T, Iiyama K, Tsubokawa T, Haruta Y, Inoue Y, Watanabe K, Hashimoto T, Higashida H, Minabe Y
    • Journal Title

      NeuroReport

      Volume: 21 Pages: 1106-1110

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurovascular coupling in the human somatosensory cortex : a singletrial study.2010

    • Author(s)
      Kikuchi, M., et al.
    • Journal Title

      Neuro Report

      Volume: 21 Pages: 1106-1110

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin signal and social behaviour : comparison among adult and in fant oxytocin, oxytocin receptor and CD38 gene knockout mice.2010

    • Author(s)
      Higashida, H., et al.
    • Journal Title

      J Neuroen docrinol

      Volume: 22 Pages: 373-379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue, T., et al.
    • Journal Title

      Neurosci Res

      Volume: 67 Pages: 181-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attentional engagement to sound : cortical hemodynamics assessed withnear-infrared spectroscopy.2010

    • Author(s)
      Remijn, G.B., et al.
    • Journal Title

      Proceedings of the Acoustical Society of Japan

      Volume: 146 Pages: 807-809

    • Related Report
      2010 Annual Research Report
  • [Presentation] 広汎性発達障害の診断・治療・経過観察総合システムの開発2012

    • Author(s)
      三邉義雄
    • Organizer
      第2回金沢大学子どものこころサミット
    • Place of Presentation
      金沢大学病院「宝ホール」金沢市(石川県)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lateralized theta wave MEG coherence and language performance in 2-to 5-year-old children2011

    • Author(s)
      Kikuchi M et al
    • Organizer
      Joint Academic Conference on Autism Spectrum Disorders
    • Place of Presentation
      日本財団ビル(東京)
    • Year and Date
      2011-12-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Lateralized theta wave MEG coherence and language performance in 2- to 5-year-old children2011

    • Author(s)
      菊知充
    • Organizer
      Exploring Autism Research Collaboration between Japan and United States : Joint Academic Conference on Autism Spectrum Disorders
    • Place of Presentation
      日本財団ビル(東京)
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2-5歳児の脳内機能結合と言語発達、そして広汎性発達障害早期診断への試み2011

    • Author(s)
      菊知充
    • Organizer
      第20回海馬と高次脳機能学会
    • Place of Presentation
      金沢市湯湧創作の森(石川県)
    • Year and Date
      2011-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 2~5歳児の脳内機能結合と言語発達、そして広汎性発達障害早期診断への試み2011

    • Author(s)
      菊知充
    • Organizer
      第20回海馬と高次脳機能学会
    • Place of Presentation
      金沢市湯湧創作の森(石川県)
    • Year and Date
      2011-10-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2-5歳児の脳内機能結合と言語発達2011

    • Author(s)
      三辺義
    • Organizer
      第38回日本脳科学会
    • Place of Presentation
      沖縄県市町村自治会館
    • Year and Date
      2011-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 2~5歳児の脳内機能結合と言語発達2011

    • Author(s)
      三辺義雄
    • Organizer
      第38回日本脳科学会
    • Place of Presentation
      沖縄県市町村自治会館
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 広汎性発達障害の診断・治療・経過観察総合システムの開発2011

    • Author(s)
      三辺義雄
    • Organizer
      第2回金沢大学子どものこころサミット
    • Place of Presentation
      金沢大学病院「宝ホール」金沢市(石川県)
    • Year and Date
      2011-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Advantages and pitfalls of segmentation methods using texture, anatomical features, and VBM on brain MR images2010

    • Author(s)
      Hayashi, N Sanada, S Miyati T, Suzuki M, Kikuchi M, Matsui O, Minabe Y, Yamamoto T, Minehiro K, Sakuta K, Takanaga M, Kawashima H
    • Organizer
      Radiological Society of North America 2010 96th Scientific Assembly and Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2010-11-30
    • Related Report
      2011 Final Research Report
  • [Presentation] バンビプラン-広汎性発達障害の早期診断にむけて-2010

    • Author(s)
      三辺義雄
    • Organizer
      第一回金沢大学子どものこころサミット
    • Place of Presentation
      日金沢大学病院「宝ホール」金沢市(石川県)
    • Year and Date
      2010-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] バンビプラン-広汎性発達障害の早期診断にむけて2010

    • Author(s)
      三辺義雄
    • Organizer
      第一金沢大学子どものこころサミット
    • Place of Presentation
      金沢大学病院「宝ホール」金沢市(石川県)
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子どもに優しい脳発達研究プロジェクト:バンビプラン2010

    • Author(s)
      菊知充、渡邊克巳、鈴木道雄、春田康博、井上芳浩、三邉義雄
    • Organizer
      第19回海馬と高次脳機能学会
    • Place of Presentation
      金沢市(石川県)
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 子どもに優しい脳発達研究プロジェクト:バンビプラン2010

    • Author(s)
      菊知充
    • Organizer
      第19回海馬と高次脳機能学会
    • Place of Presentation
      湯涌創作の森金沢市(石川県)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Auditory evoked response of speech stimuli in 3-to 4-year-old children : a magnetoencephalography study2010

    • Author(s)
      Yoshimura Y. Kikuchi, M., Shitamichi, K., Ueno, S., Nagao, K. Minabe, Y
    • Organizer
      International Congress of Clinical Neurophysiology(ICCN2010)
    • Place of Presentation
      神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Correlations between the development of cognitive functions and spontaneous MEG responses of healthy 3-to 4-year-old infants2010

    • Author(s)
      Nagao, K. Kikuchi, M., oshimura Y. Shitamichi, K., Ueno, S. Minabe, Y
    • Organizer
      International Congress of Clinical Neurophysiology(ICCN2010)
    • Place of Presentation
      神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Auditory evoked response of speech stimuli in 3-to 4-year-old children : amagnetoenc ephalography study.2010

    • Author(s)
      Yoshimura Y., et al.
    • Organizer
      International Congress of Clinical Neurophysiology(ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] NIRS-measurements of cortical hemodynamic activity in adults and preschool infants in response to static and motion stimuli2010

    • Author(s)
      Remijn, G. B., Kikuchi, M., Yoshimura, Y., Shitamichi, K., Ueno, S., Nagao, K., Kojima, H., Minabe, Y
    • Organizer
      International Congress of Clinical Neurophysiology(ICCN2010)
    • Place of Presentation
      神戸市(兵庫県)
    • Year and Date
      2010-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] NIRS-measurements of cortical hemodynamic activity in adults and preschool in fants in response to static and motion stimuli.2010

    • Author(s)
      Remijn, G.B., et al.
    • Organizer
      International Congress of Clinical Neurophysiology(ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bambi Plan : project with NIRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children2010

    • Author(s)
      三辺義雄
    • Organizer
      2010 Kanazawa-Chonbuk Symposium Speakers
    • Place of Presentation
      Symposium in Chonbuk University(Chonbuk, Korea)
    • Year and Date
      2010-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Bambi Plan project with NIRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children.2010

    • Author(s)
      三辺義雄
    • Organizer
      2010 Kanazawa-Chonbuk Symposium Speakers
    • Place of Presentation
      Symposium in Chonbuk University(Chonbuk, Korea)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bambi plan : Project with NIRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children2010

    • Author(s)
      三辺義雄
    • Organizer
      第37回日本脳科学会
    • Place of Presentation
      天津医科大学国際会議センター(中国)
    • Year and Date
      2010-10-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Bambi plan Project with IVIRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children.2010

    • Author(s)
      三辺義雄
    • Organizer
      第37回日本脳科学会
    • Place of Presentation
      天津医科大学国際会議センター(中国)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] オキシトシン放出を制御するCD38と自閉症との関係: Syntocinonの個人使用を含めて2010

    • Author(s)
      棟居俊夫、東田陽博
    • Organizer
      第3回発達障害の病態と治療研究ネットワーク
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Book] 双極性障害子どもの心の診療シリーズ4:子どもの不安障害と抑うつ2010

    • Author(s)
      棟居俊夫
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] 脳とこころのプライマリ・ケア第4巻:子どもの発達と行動:双極性障害2010

    • Author(s)
      棟居俊夫
    • Publisher
      シナジー出版
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://kokorosummit.w3.kanazawa-u.ac.jp/program.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://bambiplan.w3.kanazawa-u.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://kokorosummit.w3.kanazawa-u.ac.jp/program.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://bambiplan.w3.kanazawa-u.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://kokorosummit.w3.kanazawa-u.ac.jp/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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