Brain functional imaging study of possible effects of substance Preceptor antagonist on alcohol craving

• Project/Area Number: 22659212
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Nippon Medical School
• Principal Investigator: OKUBO Yoshiro 日本医科大学, 大学院・医学研究科, 教授 (20213663)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Hidenori 日本医科大学, 大学院・医学研究科, 教授 (30221328)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,280,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: アルコール依存症 / サブスタンス P 受容体 / 脳機能画像 / サブスタンスＰ / 薬物依存 / アルコール依存 / fMRI / サブスタンスP受容体

Research Abstract

Neurokinin-1 (NK1) receptor, the cognate receptor for substance P (SP), is highly expressed in the nucleus accumbens (NAc) and has been hypothesized to have a role in positive reward processing in the NAc in humans. Therefore, we conducted a functional MRI (fMRI) study to assess the effects of an NK1 receptor antagonist on human reward processing. Healthy adults participated in series of an fMRI study, taking either a placebo or the NK1 receptor antagonist aprepitant. fMRI showed significant decrease in blood oxygenation-level-dependent signals in the NAc during gain anticipation with the aprepitant treatment compared to the placebo treatment. These results suggest that SP/NK1 receptor system is involved in reword processing and plays a role in accentuating positive valence or alcohol craving in the reward circuit.

Research Products

• [Journal Article] Acute NK1 receptor antagonist administration affects reward incentive anticipation processing in healthy volunteers (2013)
  • Author(s): Saji K, Ikeda Y, Kim W, Shingai Y, Tateno A, Takahashi H, Okubo Y, Fukayama H, Suzuki H.
  • Journal Title: Int J Neuropsychopharmacol Volume: 13 Pages: 1-11
• [Journal Article] Cross-cultural differences in the processing of non-verbal affective vocalizations by Japanese and canadian listeners (2013)
  • Author(s): Koeda M, Belin P, Hama T, Masuda T, Matsuura M, Okubo Y.
  • Journal Title: Front Psychol Volume: 4 Pages: 105-105
  • DOI: 10.3389/fpsyg.2013.00105
• [Journal Article] Acute NK1 receptor antagonist administration affects reward incentive anticipation processing in healthy volunteers (2013)
  • Author(s): Saji K, Ikeda Y, Kim W, Shingai Y, Tateno A, Takahashi H, Okubo Y, Fukayama H, Suzuki H.
  • Journal Title: Int J Neuropsychopharmacol. Volume: Ｆｅｂ.13 Issue: 7 Pages: 1-11
  • DOI: 10.1017/s1461145712001678
  • Peer Reviewed
• [Journal Article] Caffeine's Effects on Attentional Networks in Healthy Subjects: A Pharmacological Functional Magnetic Resonance Imaging Stud (2012)
  • Author(s): Ikeda Y, Koeda M, Kim W, Tateno A, Okubo Y, Suzuki H.
  • Journal Title: J Nippon Med Sch Volume: 79(5) Pages: 318-319
• [Journal Article] Honesty mediates the relationship between serotonin and reaction to unfairness (2012)
  • Author(s): Takahashi,H., Takano,H. ,Camerer,C., Ideno,T., Okubo,S., Matsui,H., Tamari,Y., Takemura,K., Arakawa,R., Kodaka,F., Yamada,M., Eguchi,Y., Murai,T., Okubo,Y., Kato,M., Ito,H., Suhara,T
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 109(11) Issue: 11 Pages: 4281-4284
  • DOI: 10.1073/pnas.1118687109
  • Peer Reviewed
• [Journal Article] Influence of contact with schizophrenia on implicit attitudes towards schizophrenia patients held by clinical residents (2012)
  • Author(s): Omori A, Tateno A, Ideno T, Takahashi H, Kawashima Y, Takemura K, Okubo Y.
  • Journal Title: BMC Psychiatry Volume: 12 Issue: 1 Pages: 205-205
  • DOI: 10.1186/1471-244x-12-205
  • Peer Reviewed
• [Journal Article] Central nervous system drug evaluation using positron emission tomography (2011)
  • Author(s): Sekine M, Maeda J, Shimada H, Nogami T, Arakawa R, Takano H, Higuchi M, Ito H, Okubo Y, Suhara T
  • Journal Title: Clin Psychopharmacol Neurosci Volume: 9(1) Issue: 1 Pages: 9-16
  • DOI: 10.9758/cpn.2011.9.1.9
  • Peer Reviewed
• [Journal Article] Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity (2011)
  • Author(s): Marutani, T., Yahata, N., Ikeda, Y., Ito, T., Yamamoto, M., Matsuura, M., Okubo, Y., Matsushima, E., Suzuki, H. & Matsuda, T.
  • Journal Title: Psychiatry Clin Neurosci Volume: 65 Issue: 2 Pages: 191-198
  • DOI: 10.1111/j.1440-1819.2011.02189.x
  • Peer Reviewed
• [Journal Article] 【脳の機能と統合失調症-新たな診断と治療への展望-I】分子イメージングによる抗精神病薬の評価 (2011)
  • Author(s): 大久保善朗
  • Journal Title: 精神科治療学 Volume: 26 Pages: 1449-1455
• [Journal Article] SkillUp画像診断のより上手な使い方幻覚妄想の分子イメージング統合失調症とパーキンソン病の精神病症状 (2011)
  • Author(s): 大久保善朗
  • Journal Title: FrontiersinParkinsonDisease Volume: 4 Pages: 208-211
  • NAID: 40019125347
• [Journal Article] PET所見を中心にしたパリペリドン徐放錠の薬理学的考察 (2011)
  • Author(s): 大久保善朗
  • Journal Title: 精神科 Volume: 19 Pages: 152-159
• [Journal Article] [18F]AV-45によるアミロイドイメージング (2011)
  • Author(s): 舘野周,大久保善朗
  • Journal Title: 日本臨牀増刊号,認知症学(前)-その解明と治療の最新知見-,日本臨牀増刊号 Volume: 1008 Pages: 561-564
• [Journal Article] 講演紹介「PETを用いた新規抗精神病薬blonanserinの評価」 (2011)
  • Author(s): 舘野周
  • Journal Title: 臨床精神薬理 Volume: 14(2) Pages: 334-341
• [Journal Article] Cerebral activation associated with speech sound discrimination during the diotic listening task : an fMRI study. (2010)
  • Author(s): Ikeda Y, Yahata N, Takahashi H, Koeda M, Asai K, Okubo Y, Suzuki H.
  • Journal Title: Neurosci Res. Volume: 67 Pages: 65-71
  • Peer Reviewed
• [Journal Article] Working memory processing for human voice perception in a patient with mild cognitive impairment : an FMRI study. (2010)
  • Author(s): Koeda M, Tateno A, Ishizaka K, Saijo T, Okubo Y.
  • Journal Title: J Nippon Med Sch. Volume: 77 Pages: 188-189
  • Peer Reviewed
• [Journal Article] Functional deficits in the extrastriate body area during observation of sports-related actions in schizophrenia. (2010)
  • Author(s): Takahashi H, Kato M, Sassa T, Shibuya T, Koeda M, Yahata N, Matsuura M, Asai K, Suhara T, Okubo Y.
  • Journal Title: Schizophr Bull. Volume: 36 Pages: 642-647
  • Peer Reviewed
• [Presentation] Cultural Effects on the Perception of Non-linguistic Affective Vocalization by Japanese and Canadian Subjects (2012)
  • Author(s): Koeda M, Pascal B, Tomoko H, Matuura M, Okubo Y
  • Organizer: British Neuropsychiatry Association 25th Anniversary AGM
  • Place of Presentation: Child Health, London
• [Presentation] Cerebral activation associated withsounds of dental treatment in subjects with dental fear: An fMRI study (2012)
  • Author(s): Karibe H, Aoyagi-Naka K, Koeda M, Tateno A, Suzuki H, Okubo Y
  • Organizer: International Association for Disability and Oral Health 2012
• [Presentation] A Global phase 2b efficacy and safety trial to investigate florbetaben beta-amyloid brain positron emission tomography in Alzheimer's disease (2012)
  • Author(s): Sabri O, Gertz H, Ischihara K, Tateno A, Drzezga T, Grimmer T, Senda Y, Yamamoto Y, Reininger C, Barhtel H
  • Organizer: The 6th Human Amyloid Imaging
• [Presentation] 分子メージングからみた向精神薬の薬効評価 (2011)
  • Author(s): 大久保善朗
  • Organizer: 第32回日本臨床薬理学会年会
  • Place of Presentation: 浜松
  • Year and Date: 2011-12-03
• [Presentation] 分子イメージングからみた精神疾患の病態と治療 (2011)
  • Author(s): 大久保善朗
  • Organizer: 第31回日本精神科診断学会
  • Place of Presentation: 松本
  • Year and Date: 2011-11-27
• [Presentation] Effect of caffeine and placebo on cerebral response to vocal emotional sounds and working memoryy:An fMRI study (2011)
  • Author(s): Koeda M, Nakano Y, Ikeda Y, Tateno A, Kim WC, Takahashi H, Suzuki H, Matsuura M, Okubo Y
  • Organizer: 17th Annual Meeting of the
  • Place of Presentation: Organization on HBM
• [Presentation] Effects of placebo and lorazepam on emotional voice processing: An fMRI study (2011)
  • Author(s): Koeda M, TatenoA, Yahata N, Ogawa K, Shingai Y, Hama T, Matsuura M, Takahashi H, Okubo Y
  • Organizer: The British Neuropsychiatry Association 24th Annual General Meeting
• [Presentation] Attitudes towards schizophrenia measured with the Implicit Association Test in medical students and clinical residents in Japan (2011)
  • Author(s): Oomori A, Kawashima Y, Tateno A, Ideno H, Takahashi H, Takemura K, Okubo Y
  • Organizer: 2nd Asian Congress of Schizophrenia Research
• [Presentation] Molecular imaging of antipsychotic drug action using positron emission tomography (2011)
  • Author(s): Okubo Y
  • Organizer: The AnnualMeeting of Schizophrenia Society in
  • Place of Presentation: Korea(Tegu)
• [Presentation] Effect of Caffeine and Placebo on Cerebral Response to Vocal Emotional Soundsand Working Memory: An fMRI Study (2011)
  • Author(s): Koeda M, Yukari N, Yumiko I, Amane T, Kim W, Takahashi H, Suzuki H,Okubo Y
  • Organizer: 17th Annual Meeting of the Organization on Human Brain Mapping
  • Place of Presentation: Quebec, Canada
• [Presentation] Paliperidone徐放錠の脳内動態特性 (2011)
  • Author(s): 大久保善朗
  • Organizer: 大分県精神科医会学術講演会
  • Place of Presentation: 別府
• [Presentation] PET研究からみた統合失調症の病態 (2011)
  • Author(s): 大久保善朗
  • Organizer: 1st Psychiatry Frontier
• [Presentation] うつ病の治療と画像診断 (2011)
  • Author(s): 大久保善朗
  • Organizer: 城北臨床精神医学会(第17回)
• [Presentation] 統合失調症患者の音声プロソディー認知に関する機能的MRI研究 (2011)
  • Author(s): 肥田道彦,高橋英彦,八幡憲明,松浦雅人,浅井邦彦,大久保善朗
  • Organizer: 日本統合失調症学会(第6回)
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] 健常者における注意ネットワークに対するカフェインの効果:薬理学的fMRI研究 (2011)
  • Author(s): 池田裕美子、肥田道彦、金禹〓、八幡憲明、高橋英彦、舘野周、大久保善朗、鈴木秀典
  • Organizer: 第34回日本神経科学大会
• [Presentation] Molecular imaging of psychotropic drug action using positron emission tomography (2010)
  • Author(s): Okubo Y
  • Organizer: The World Psychiatric Association International Congress
  • Place of Presentation: Beijing, China
  • Year and Date: 2010-09-03
• [Presentation] 精神疾患における画像診断 (2010)
  • Author(s): 大久保善朗
  • Organizer: 北区医師会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-15
• [Book] [分担]脳内イメージングからみた心身医学:疼痛障害の画像所見.専門医のための精神科臨床リュミエール(石津宏) (2011)
  • Author(s): 舘野周,大久保善朗
  • Publisher: 中山書店
• [Book] [分担]脳血流量,関心領域など.精神医学事典(加藤敏他) (2011)
  • Author(s): 大久保善朗
  • Publisher: 弘文社
• [Book] [分担]PETによる薬効評価からみた非定型高精神病薬の投与方法.統合失調症治療の新たなストラテジー(石郷岡純他) (2011)
  • Author(s): 大久保善朗
  • Publisher: 先端医学者