| Project/Area Number |
22659213
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TORIUMI Kazuya 東京都医学総合研究所, 固有研究員 (10549421)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,290,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 精神薬理学 / 遺伝子 / 薬物依存 / プロテオミクス / Shati / 精神神経疾患 / shati / ドパミン / メタンフェタミン / N-アセチルアスパラギン酸 / 側坐核 / アセチルトランスフェラーゼ |
|---|
| Research Abstract |
To reveal function of a novel drug dependence-related molecule “Shati,” we exploredSHATI-binding proteins using pull-down assays and identified a number of components of the adaptorprotein (AP)-2 complex, which is a multimeric protein localized to the plasma membrane that functionsto internalize receptors during clathrin-mediated endocytosis. We demonstrated a novel function ofSHATI that promotes the localization of DA receptors to the cell surface via an association with theadaptor protein (AP)-2 complex, thereby inhibiting METH dependence. Furthermore, we show thatSHATI is both associated and colocalized with microtubules in neurons, and regulated neuriteelongation.
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