Analysis of L1 retrotransposition activity in the brains of patients with psychiatric disorders.
| Project/Area Number |
22659214
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo (2011-2012)
The Institute of Physical and Chemical Research (2010) |
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Principal Investigator |
IWAMOTO Kazuya 東京大学, 医学部附属病院, 特任准教授 (40342753)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 死後脳 / 神経細胞 / トランスポゾン / 統合失調症 / 精神疾患 / LINE-1 / 神経発達障害仮説 / 抗精神病薬 / エピジェネティクス / 双極性障害 |
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| Research Abstract |
We measured LINE-1 copy number in brains of patients with psychiatric disorders by Taqman-based PCR. We identified significant increase of LINE-1 copy number in brains of patients with schizophrenia in two different cohorts. This finding is well concordant with neurodevelopmental model of schizophrenia.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene.2013
Author(s)
Nishioka Masaki, Shimada Takafumi, Bundo Miki, Ukai Wataru, Hashimoto Eri, Saito Toshikazu, Kano Yukiko, Sasaki Tsukasa, Kasai Kiyoto, Kato Tadafumi, Iwamoto Kazuya.
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Journal Title
International Journal of Developmental Neuroscience
Volume: 31
Pages: 89-95
Related Report
Peer Reviewed
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