| Project/Area Number |
22659215
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
KUNUGI Hiroshi 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第三部, 部長 (40234471)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,290,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 脳・神経 / 脳神経疾患 / 神経科学 / 薬学 / バイオテクノロジー |
|---|
| Research Abstract |
Phenylalanine is required for the synthesis of catecholamines. C^^<13>-labeled phenylalanine breath test(C^^<13>-PBT), in which total C^^<13> O_2 produced through metabolism of C^^<13>-phenylalanine was measured as C^^<13> O_2/C^^<12> O_2 ratio, was administered to psychiatric patients. The subjects were 91 schizophrenia, 77 depression, 32 bipolar disorder patients and 181 controls. C^^<13>-PBT results and serum BH4 level were significantly lower in the schizophrenia patients than in the controls. C^^<13>-PBT after administration of BH4 was conducted in patients who had had both low C^^<13>-PBT results and serum BH4 level, however C^^<13>-PBT results were not improved. Examination of relationship between phenylalanine metabolism measured by breath test, BH4 level, and psychiatric symptoms may attribute to elucidate the pathophysiology of mental disease.
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