Cell tracking technique of iPS cells and clinical application using PET and MRI
| Project/Area Number |
22659217
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto College of Medical Science (2011)
Gunma University (2010) |
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Principal Investigator |
ENDO Keigo 京都医療科学大学, 医療科学部, 学長 (10115800)
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| Co-Investigator(Kenkyū-buntansha) |
中嶌 崇仁 群馬大学, 大学院・医学系研究科, 寄附講座教員 (70375559)
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| Research Collaborator |
HANAOKA Hirofumi 千葉大学, 助教 (50361390)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | 放射線 / 癌 / 画像 / iPS細胞 / PET / MRI / 脳神経疾患 |
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| Research Abstract |
iPS cells were successfully labeled with radioisotopes such as^<18> F,^<64> Cu in a good yield. Biodistribution of radiolabeled iPS cells in mice were clearly visualized using PET, indicating the potential of PET imaging of iPS cells. On the other hands, iPS cells labeled with SPIO(contrast agent for MRI), injected into the tail veins of mice, could not be imaged with MRI due to the susceptibility effect of air in the lung.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy2012
Author(s)
Yoshioka H, Yamamoto S, Hanaoka H, Iida Y, Paudyal P, Higuchi T, Tominaga H, Oriuchi N, Nakagawa H, Shiba Y, Yoshida K, Osawa R, Katagiri T, Tsunoda T, Nakamura Y, Endo K
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Journal Title
Cancer Immunol Immunother
Volume: 61
Issue: 8
Pages: 1211-1220
DOI
Related Report
Peer Reviewed
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