Construction of the fundamental technology for development of strategic internal radiation therapy agents

• Project/Area Number: 22659219
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 放射線治療学 / 内用放射線治療 / オージェ電子 / 内照射治療 / 癌 / 分子標的 / 分子イメージング

Research Abstract

Br-77 is one of Auger electron emitting radionuclide. Auger electron emitting radiopharmaceuticals are attractive for targeted nanoirradiation therapy. The DNA of malignant cells is particularly suitable target. The aim of this study is to evaluate 5-[^<77> Br] bromo-4'-thio-2'-deoxyuridine(^<77> Br-BTdU) as a radiopharmaceutical for DNA targeted nanoirradiation therapy and(2S,αS)-2-(α-(2-[^<77> Br] bromophenoxy) benzyl) morpholine((SS)-^<77> Br-BPB) as a radiopharmaceuticals for cell membrane targeted nanoirradiation therapy.^<77> Br-BTdU is a potential radiopharmaceutical for DNA targeted nanoirradiation therapy and(SS)-^<77> Br-BPBM is also a potential radiopharmaceuticals for cell membrane targeted nanoirraidation therapy.

Research Products

• [Journal Article] Copper-64-diacetyl-bis(N4-methylthiosemicarbazone) accumulates in rich regions of CD133^+highly tumorigenic cells in mouse colon carcinom (2010)
  • Author(s): Yoshii Y, Furukawa T, Kiyono Y, Watanabe R, Waki A, Mori T, Yoshii H, Oh M, Asai T, Okazawa H, et al.
  • Journal Title: Nucl Med Biol Volume: 37 Issue: 4 Pages: 395-404
  • DOI: 10.1016/j.nucmedbio.2009.12.011
  • Peer Reviewed
• [Journal Article] Copper-64-diacetyl-bis(N^<4>-methylthiosemicarbazone) accumulates in rich regions of CD133^<+> highly tumorigenic cells in mouse colon carcinoma. (2010)
  • Author(s): Yoshii Y, et al.
  • Journal Title: Nucl Med Biol. Volume: 37 Pages: 395-404
  • Peer Reviewed
• [Presentation] 放射性臭素標識プローブの開発:診断から治療へ (2012)
  • Author(s): 清野泰
  • Organizer: 震災復興分子イメージング化学シンポジウム
  • Place of Presentation: 東北大学(仙台市)
  • Year and Date: 2012-03-06
• [Presentation] 放射性臭素標識プローブの開発:診断から治療へ (2012)
  • Author(s): 清野泰
  • Organizer: 震災復興分子イメージング化学シンポジウム
  • Place of Presentation: 東北大学(仙台市)(招待講演)
  • Year and Date: 2012-03-06
• [Presentation] Evaluation of radiobrominated(2S,αS)-2-(α-(2-bromophenoxy) benzyl) morpholine as an imaging probe for brain norepinephrine transporter (2011)
  • Author(s): Kiyono Y, et al.
  • Organizer: Annual Congress of the European Association of Nuclear Medicine(EANM2011)
  • Place of Presentation: Birmingham Convention Center(Birmingham, UK)
• [Presentation] In vivo evaluation of radiobromine-labeled 5-bromo-4-thio-2'-deoxyuridine as an imaging agent for tumor proliferation (2011)
  • Author(s): Kiyono Y, et al.
  • Organizer: Society of Nuclear Medicine, the 58th Annual Meeting
  • Place of Presentation: San Antonio Convention Center(San Antonio, USA)
• [Presentation] 脳内ノルエピネフリン・トランスポークのイメージングを目的とする放射性臭素標識PETプローブの開発 (2011)
  • Author(s): 清野泰, 他
  • Organizer: 第6回日本分子イメージング学会総会学術集会
  • Place of Presentation: 神戸国際会議場(神戸市)
• [Presentation] In vivo evaluation of radiobromine-labeled 5-bromo-4-thio-2'-deoxyuridine as an imaging agent for tumor proliferation (2011)
  • Author(s): Kiyono Y, et al
  • Organizer: Society of Nuclear Medicine, the 58th Annual Meeting
  • Place of Presentation: San Antonio Convention Center (San Antonio, USA)
• [Presentation] Evaluation of radiobrominated (2S,αS)-2-(α-(2-bromophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter (2011)
  • Author(s): Kiyono Y, et al
  • Organizer: 19th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: VU University (Amsterdam, The Netherlands)
• [Presentation] Evaluation of radiobrominated (2S, αS)-2-(α-(2-bromophenoxy)benzyl)morpholine as an imaging probe for brain norepinephrine transporter (2011)
  • Author(s): Kiyono Y, et al
  • Organizer: Annual Congress of the European Association of Nuclear Medicine (EANM2011)
  • Place of Presentation: Birmingham Convention Center (Birmingham, UK)
• [Presentation] 脳内ノルエピネフリン・トランスポータイメージングPET薬剤としての放射性臭素標識(SS)-BPBMの基礎的評価 (2011)
  • Author(s): 清野泰, 他
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場(つくば市)
• [Presentation] 放射性臭素標識5-bromo-4' thio-2'-deoxyuridineの増殖能イメージングプローブとしての基礎的検討 (2010)
  • Author(s): 清野泰, 他
  • Organizer: 第10回放射性医薬品・画像診断薬研究会
  • Place of Presentation: 京都テルサ(京都市)
  • Year and Date: 2010-12-04
• [Presentation] Development and Evaluation of Radiobromine Labeled Thymidine Derivative for Proliferative Tumor Imaging (2010)
  • Author(s): Kiyono Y, et al.
  • Organizer: CIS Workshop 2010
  • Place of Presentation: Hokkaido University(Sapporo, Japan)
  • Year and Date: 2010-05-28
• [Presentation] Development and Evaluation of Radiobromine Labeled Thymidine Derivative for Proliferative Tumor Imaging (2010)
  • Author(s): Kiyono Y
  • Organizer: CIS Workshop2010
  • Place of Presentation: Hokkaido University (Sapporo, Japan)
  • Year and Date: 2010-05-28
• [Presentation] Development of radiobromine-labeled 5-bromo-4'-thio-2'-deoxyuridine as atumor proliferation imaging agent (2010)
  • Author(s): Kiyono Y, et al.
  • Organizer: Annual Congress of the European Association of Nuclear Medicine(EANM2010)
  • Place of Presentation: Austria Center Vienna(Vienna, Austria)
• [Presentation] Development of radiobromine-labeled thymidine analogue as a tumor proliferation imaging agent (2010)
  • Author(s): Kiyono Y, et al.
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto International Conference Center(Kyoto, Japan)
• [Presentation] Evaluation of radiobromine-labeled 5-bromo-4'-thio-2'-deoxyuridine as a tumor proliferation imaging agent (2010)
  • Author(s): Kiyono Y, et al.
  • Organizer: the 57th Annual Meeting
  • Place of Presentation: Society of Nuclear Medicine, Salt Palace Convention Center(Salt Lake City, USA)
• [Presentation] ナノパターン足場構造を用いた三次元がん細胞培養法:分子イメージング研究における新規モデル (2010)
  • Author(s): 黒田悠生, 他
  • Organizer: 第5回日本分子イメージング学会学術集会
  • Place of Presentation: ピアザ淡海(大津市)
• [Presentation] 腫瘍の増殖能イメージングを目的とする放射性臭素標識ヌクレオシド誘導体の開発 (2010)
  • Author(s): 佐野圭祐, 他
  • Organizer: 第5回日本分子イメージング学会学術集会
  • Place of Presentation: ピアザ淡海(大津市)
• [Presentation] Evaluation of radiobromine-labeled 5-bromo-4'-thio-2'-deoxyuridine as a tumor proliferation imaging agent. (2010)
  • Author(s): Kiyono Y, et al.
  • Organizer: Society of Nuclear Medicine, the 57th Annual Meeting
  • Place of Presentation: Salt Palace Convention Center (Salt Lake City, USA)
• [Presentation] Evaluation of ^<64>Cu-ATSM for an internal radiotherapy agent : ^<64>Cu-ATSM treatment reduces CD133^<+> highly tumorigenic cells and metastatic ability of tumors. (2010)
  • Author(s): Yoshii Y, et al.
  • Organizer: Society of Nuclear Medicine, the 57th Annual Meeting
  • Place of Presentation: Salt Palace Convention Center (Salt Lake City, USA)
• [Presentation] 非生物由来ナノパターンを用いた新規三次元培養法によるがん細胞スフェロイド形成と低酸素環境の検討 (2010)
  • Author(s): 吉井幸恵, 他
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: タワーホール船堀(東京)
• [Presentation] Development of radiobromine-labeled thymidine analogue as a tumor proliferation imaging agent. (2010)
  • Author(s): Kiyono Y, et al.
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto International Confer ence Center (Kyoto, Japan)
• [Presentation] 3D tumor spheroids constructed with nano-sized pattern scaffoldings : a novel model for molecular imaging research. (2010)
  • Author(s): Yoshii Y, et al.
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto International Confer ence Center (Kyoto, Japan)
• [Presentation] Development of radiobromine-labeled 5-bromo-4'-thio-2'-deoxyuridine as atumor proliferation imagine agent. (2010)
  • Author(s): Kiyono Y, et al.
  • Organizer: Annual Congress of the European Association of Nuclear Medicine (EANM2010)
  • Place of Presentation: Austria Center Vienna (Vienna, Austria)
• [Presentation] 腫瘍増殖能イメージング薬剤としての放射性標識5-bromo-4'-thio-2'-deoxyuridineの基礎的評価 (2010)
  • Author(s): 清野泰, 他
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(さいたま市)
• [Presentation] 64Cu-ATSMによる腫瘍内がん幹細胞局在領域イメージング:内用放射線治療への応用 (2010)
  • Author(s): 吉井幸恵, 他
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(さいたま市)
• [Patent(Industrial Property Rights)] アポトーシス誘導剤 (2011)
  • Inventor(s): 清野泰
  • Industrial Property Rights Holder: 国立大学法人福井大学
  • Industrial Property Number: 2011-073353
  • Filing Date: 2011-03-29
• [Patent(Industrial Property Rights)] アポトーシス誘導材 (2011)
  • Inventor(s): 清野泰, 他
  • Industrial Property Rights Holder: 国立大学法人福井大学
  • Filing Date: 2011-03-29