| Project/Area Number |
22659220
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OUCHI Yasufumi 鳥取大学, 医学部・付属病院, 講師 (40304224)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥1,970,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | 動注化学療法 / 抗癌剤 / ドラッグデリバリーシステム / 悪性腫瘍 / 超音波造影剤 / マイクロバブル |
|---|
| Research Abstract |
As a chemotherapy for hepatocellular carcinoma, hepatic arterial infusion chemotherapy has been mainly performed. But no effective drug delivery system for the treatment of hepatocellular carcinoma has been developed. We examined usefulness of micro-bubbles formed at the surface of ultrasonographic contrast media as an intra-arterial drug delivery system. The affinity of micro-bubbles and anti-cancer drugs (CDDP, MMC, epi-ADR) was defective. Micro-bubbles released powder of anticancer drugs within a short time. Micro-bubbles made by whipping methods were not to be an effective drug delivery system.
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