| Budget Amount *help |
¥3,330,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
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| Research Abstract |
We already proposed the formation of DNA double-strand breaks (DSBs) by heat-treatment. Here we found that the HR-deficient cells were sensitive, and were low efficiency of DSB repair by heat when compared to the NHEJ-deficient cells and their parental cells. In addition, we demonstrated that heat-induced DSBs were repaired by HR. Our novel findings suggest that the HR exerts an importantrole in the radio-sensitization mechanism by heat.
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