Elucidation of the radio-sensitization mechanism by heat
Project/Area Number |
22659224
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Radiation science
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Research Institution | Gunma University |
Principal Investigator |
TAKAHASHI Akihisa 群馬大学, 先端科学研究指導者育成ユニッ ト, 准教授 (60275336)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,330,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
|
Keywords | 放射線治療 / 温熱治療 / 感受性 / 放射線増感 / DNA二本鎖切断 / 放射線治療学 |
Research Abstract |
We already proposed the formation of DNA double-strand breaks (DSBs) by heat-treatment. Here we found that the HR-deficient cells were sensitive, and were low efficiency of DSB repair by heat when compared to the NHEJ-deficient cells and their parental cells. In addition, we demonstrated that heat-induced DSBs were repaired by HR. Our novel findings suggest that the HR exerts an importantrole in the radio-sensitization mechanism by heat.
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Report
(4 results)
Research Products
(118 results)
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[Journal Article] Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation.2012
Author(s)
Yosuke Nakagawa,Akihisa Takahashi,Atsuhisa Kajihara,Nobuhiro Yamakawa,Yuichiro Imai,Ichiro Ota,Noritomo Okamoto,Eiichiro Mori,Taichi Noda,Yoshiya Furusawa,Tadaaki Kirita,Takeo Ohnishi
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 423 (4)
Issue: 4
Pages: 654-660
DOI
Related Report
Peer Reviewed
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[Journal Article] siRNA targeted for nbs1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells2011
Author(s)
Okamoto N, Takahashi A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T.
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Journal Title
Int J Hyperthermia
Volume: 27
Issue: 3
Pages: 297-304
DOI
Related Report
Peer Reviewed
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[Journal Article] ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating2010
Author(s)
Takahashi A, Mori E, Su X, Nakagawa Y, Okamoto N, Uemura H, Kondo N, Noda T, Toki A, Ejima Y, Chen JD, Ohnishi K, Ohnishi T.
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Journal Title
Journal of Radiation Research
Volume: 51
Issue: 4
Pages: 417-422
DOI
NAID
ISSN
0449-3060, 1349-9157
Related Report
Peer Reviewed
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[Presentation] DNA二本鎖切断修復を分子標的としたLET依存的な殺細胞効果2013
Author(s)
久保誠, 高橋昭久, 馬洪玉, 中川彰子, 吉田由香里, 古澤佳也, 小林泰彦, 舟山知夫, 金井達明, 大野達也,中野隆史.
Organizer
第3回国際放射線神経生物学会大会
Place of Presentation
沖縄 万国津梁館
Related Report
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[Presentation] ヒト肺がん細胞の炭素線治療における標的としてのNHEJ修復.2013
Author(s)
馬洪玉, 高橋昭久, 久保誠, 中川彰子, 吉田由香里, 古澤佳也, 小林泰彦, 舟山知夫, 金井達明, 大野達也, 中野隆史.
Organizer
第15回癌治療増感研究シンポジウム
Place of Presentation
奈良 猿沢荘
Related Report
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[Presentation] LET依存的な殺細胞効果におよぼすDNA二本鎖切断修復の役割.2013
Author(s)
高橋昭久, 久保誠, 馬洪玉, 中川彰子, 吉田由香里, 古澤佳也, 小林泰彦, 舟山知夫, 金井達明, 大野達也,中野隆史.
Organizer
第6回 Quantum Medicine 研究会
Place of Presentation
茨城 茨城大学
Related Report
Invited
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[Presentation] DNA修復を標的とした温熱増感研究2011
Author(s)
高橋昭久,森英一朗,近藤夏子,野田太一,梶原淳久,長谷川正俊,大西武雄
Organizer
第17回癌治療増感研究シンポジウム
Place of Presentation
赤門鍼灸柔整専門学校(宮城県)
Year and Date
2011-06-08
Related Report
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