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Research for the establishment of pluripotent stem cells from normal human culture cells and tissue engineering

Research Project

Project/Area Number 22659228
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionUniversity of Toyama

Principal Investigator

SHIMADA Yutaka  富山大学, 大学院・医学薬学研究部(医学), 准教授 (30216072)

Co-Investigator(Kenkyū-buntansha) TSUKADA Kazuhiro  富山大学, 大学院・医学薬学研究部(医学), 教授 (90171967)
OKUMURA Tomoyuki  富山大学, 大学院・医学薬学研究部(医学), 助教 (10533523)
Co-Investigator(Renkei-kenkyūsha) AOI Takayuki  京都大学, iPS細胞研究所, 教授 (00546997)
SATO Fumiaki  京都大学, 大学院・医学研究科, 特定講師 (20467426)
NAKAMURA Masato  富山大学, 大学院・理工学研究部(工学), 教授 (90301803)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords実験外科学 / ヒト上皮細胞 / 多能性幹細胞 / 消化管組織 / 線維芽細胞 / 山中4因子 / 組織構築 / 腺組織
Research Abstract

We have established 9 human esophageal epithelial cell strains, one human gastric epithelial cell strain and one gall bladder epithelia cell strain. We have established iPS cells from esophageal epithelial cells(TYE-1), however we lost it due to infection. In order to support establishment of tissue structure, we also have established 2 esophageal fibroblast cell strains, 2 gastric esophageal fibroblast cell strains, 1 gallbladder fibroblast cell strain, 1 bile duct fibroblast cell strain, 2 leiomyoma cell strains and so on.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results)

  • [Journal Article] Prognostic significance of NANOG and KLF4 in breast carcinoma patients2012

    • Author(s)
      Nagata T, Shimada Y, Sekine S, Osawa S, Hori R, Matsui K, Okumura T, Fukuoka J, Tsukada K
    • Journal Title

      Breast Cancer 2012

      Volume: 21 Issue: 1 Pages: 96-101

    • DOI

      10.1007/s12282-012-0357-y

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Expression analysis of iPS inductive gene in gastrointestinal cancer by tissue microarray2011

    • Author(s)
      Sekine S, Shimada Y, Okumura T, Osawa S, Moriyama M, Matsui K, Sawada S, Nagata T, Fukuoka J, Tsukada K
    • Organizer
      AACR 102nd annual meeting
    • Place of Presentation
      Orland
    • Related Report
      2011 Final Research Report
  • [Presentation] Expression analysis of iPS inductive gene in gastrointestinal cancer by tissue microarray2011

    • Author(s)
      Sekine S
    • Organizer
      AACR 102nd ANNUAL MEETING
    • Place of Presentation
      オーランド
    • Related Report
      2011 Annual Research Report
  • [Presentation] The influence of iPS-inducing factors NANOG and KLF4 in the prognosis of patients with breast cancer2011

    • Author(s)
      Nagata T
    • Organizer
      2011 Breast Cancer Symposium
    • Place of Presentation
      サンフランシスコ
    • Related Report
      2011 Annual Research Report
  • [Presentation] 消化器病の生物学的特性解明のための細胞培養を中心とした基礎研究2010

    • Author(s)
      嶋田裕
    • Organizer
      第24回日本消化器病学会甲信越支部教育講演会
    • Place of Presentation
      甲府
    • Year and Date
      2010-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 消化器病の生物学的特性解明のための細胞培養を中心とした基礎研究2010

    • Author(s)
      嶋田裕
    • Organizer
      第24回日本消化器病学会甲信越支教育講演会
    • Place of Presentation
      甲府
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 組織アレイによる消化器癌におけるiPS誘導遺伝子の発現解析2010

    • Author(s)
      嶋田裕,奥村知之,大澤宗士,関根慎一,森山亮仁,澤田成朗,長田拓哉,福岡順也,塚田一博
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Analysis of iPS inductive gene expression by esophageal cancer tissue array2010

    • Author(s)
      Shimada Y, Okumura T. Nagata T., Osawa S., Sekine S., Moriyama M., Fukuoka J., Tsukada K
    • Organizer
      12th world congress of the diseases of the esophagus
    • Place of Presentation
      Kagoshima
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of iPS inductive gene expression by esophageal cancer tisse array2010

    • Author(s)
      Shimada Y
    • Organizer
      12th world congress of the diseases of the esophagus
    • Place of Presentation
      Kagoshima
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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