Optimization and individualization of breast cancer treatment using OS-MSP.

• Project/Area Number: 22659231
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Osaka University
• Principal Investigator: NAKAYAMA Takahiro 大阪大学, 医学系・研究科, 助教 (30527700)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: メチル化 / GSTP1 / RASSF1A / FARβ2 / 14-3-3δ / 個別化 / 治療効果予測 / RARβ2 / Rassf1a / RARb / 予後予測

Research Abstract

・OS-MSP, which can detect DNA methylation in serum sensitively, has been established.
・This method would be useful to predict the efficacy of neoadjuvant chemotherapy.
・DNA methylation and the amount of DNA from cancer in serum would be useful prognostic marker(submitted).

Research Products

• [Journal Article] Detection of aberrant promoter methylation of GSTP1, RASSF1A, and RARβ2 in serum DNA of patients with breast cancer by a newly established one-step methylation-specific PCR assay (2012)
  • Author(s): Yamamoto N, Nakayama T et. al
  • Journal Title: Breast Cancer Res Treat Volume: 132(1) Pages: 165-73
  • Peer Reviewed
• [Journal Article] 14-3-3σexpression is associated with poor pathological complete response to neoadjuvant chemotherapy in human breast cancers (2012)
  • Author(s): Nakamura Y, Nakayama T et. al
  • Journal Title: Breast Cancer Res Treat
  • Peer Reviewed
• [Journal Article] GSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer (2012)
  • Author(s): Miyake T, Nakayama T et. al
  • Journal Title: Cancer Sci
  • Peer Reviewed
• [Journal Article] 14-3-3σ expression is associated with poor pathological complete response to neoadjuvant chemotherapy in human breast cancers (2012)
  • Author(s): Nakamura Y, Nakayama T, et.al.
  • Journal Title: Breast Cancer Res Treat Volume: Feb 8(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] GSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer (2012)
  • Author(s): Miyake T, Nakayama T, et.al.
  • Journal Title: Cancer Sci Volume: Feb 9(Epub ahead of print)
  • Peer Reviewed