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Pathogenesis of shaggy aorta syndrome

Research Project

Project/Area Number 22659232
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionYamaguchi University

Principal Investigator

YOSHIMURA Koichi  山口大学, 大学院・医学系研究科, 准教授(特命) (00322248)

Co-Investigator(Kenkyū-buntansha) AOKI Hiroki  久留米大学, 循環器病研究所, 教授 (60322244)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,370,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Keywords大動脈
Research Abstract

Shaggy aorta syndrome is a difficult-to-treat disease causing peripheral, renal and visceral ischemia caused by multiple cholesterol emboli from the aorta. The mechanisms underlying the development of shaggy aorta remain largely unknown. In this study, we examined the role of ASC/Caspase-1 in the development of shaggy aorta with cholesterol crystals.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (30 results)

All 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 10 results) Presentation (12 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Important Role of the Angiotensin II Pathway in Producing Matrix Metalloproteinase-9 in Human Thoracic Aortic Aneurysms2013

    • Author(s)
      Nagasawa A, Yoshimura K, Suzuki R, Mikamo A, Yamashita O, Ikeda Y, Tsuchida M, Hamano K
    • Journal Title

      Journal of Surgical Research

      Volume: (in press) Issue: 1 Pages: 472-7

    • DOI

      10.1016/j.jss.2012.12.012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm2012

    • Author(s)
      Yoshimura K, Aoki H
    • Journal Title

      International Journal of Vascular Medicine

      Volume: 2012: 648167 Pages: 648167-648167

    • DOI

      10.1155/2012/648167

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage-derived Angiopoietin- like Protein 2 Accelerates the Development of Abdominal Aortic Aneurysm.2012

    • Author(s)
      Tazume H, Miyata K, Tian Z, Endo M, Horiguchi H, Takahashi O, Horio E, Tsukano H, Kadomatsu T, Nakashima Y, Kunitomo R, Kaneko Y, Moriyama S, Sakaguchi H, Okamoto K, Hara M, Yoshinaga T, Yoshimura K, Aoki H, Araki K, Hao H, Kawasuji M, Oike Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32(6) Issue: 6 Pages: 1400-1409

    • DOI

      10.1161/atvbaha.112.247866

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of development of abdominal aortic aneurysm by glycolysis restriction.2012

    • Author(s)
      Tsuruda T, Hatakeyama K, Nagamachi S, Sekita Y, Sakamoto S, Endo GJ, Nishimura M, Matsuyama M, Yoshimura K, Sato Y, Onitsuka T, Imamura T, Asada Y, Kitamura K.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Issue: 6 Pages: 1410-1417

    • DOI

      10.1161/atvbaha.111.237065

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heart Failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling2012

    • Author(s)
      Yosuke Miyazaki
    • Journal Title

      PLOS ONE

      Volume: 7 Issue: 4 Pages: 35875-35875

    • DOI

      10.1371/journal.pone.0035875

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice2011

    • Author(s)
      Yoshimura, K., Ueno, M., Lee, S., Nakamura, Y., Sato, A., Yoshimura, K., Kishima, H., Yoshimine, T. and Yamashita, T
    • Journal Title

      Neurosci. Res

      Volume: 71(3) Issue: 3 Pages: 266-277

    • DOI

      10.1016/j.neures.2011.07.1830

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Innocent Bystander? : Intraluminal Thrombus in Abdominal Aortic Aneurysm2011

    • Author(s)
      Yoshimura K, Ikeda Y, Aoki H
    • Journal Title

      Atherosclerosis

      Volume: 218(2) Issue: 2 Pages: 285-286

    • DOI

      10.1016/j.atherosclerosis.2011.06.027

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process2011

    • Author(s)
      Taizo Kimura
    • Journal Title

      Pathol Int

      Volume: 61 Issue: 10 Pages: 559-564

    • DOI

      10.1111/j.1440-1827.2011.02699.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 慢性炎症と大動脈瘤2011

    • Author(s)
      青木浩樹, 吉村耕一
    • Journal Title

      呼吸と循環

      Volume: 59(9) Pages: 883-889

    • Related Report
      2012 Final Research Report
  • [Journal Article] 大動脈瘤の分子病態2011

    • Author(s)
      吉村耕一, 長澤綾子, 山下 修, 濱野公一
    • Journal Title

      最新医学

      Volume: 66(7) Pages: 1628-1633

    • NAID

      130003376931

    • Related Report
      2012 Final Research Report
  • [Journal Article] Resveratrol Prevents the Development of Abdominal Aortic Aneurysm through Attenuation of Inflammation, Oxidative Stress, and Neovascularization2011

    • Author(s)
      Kaneko H, Anzai T, Morisawa M, Kohno T, Nagai T, Anzai A, Takahashi T, Shimoda M, Sasaki A, Maekawa Y, Yoshimura K, Aoki H, Tsubota K, Yoshikawa T, Okada Y, Ogawa S, Fukuda K
    • Journal Title

      Atherosclerosis

      Volume: 217(2) Issue: 2 Pages: 350-357

    • DOI

      10.1016/j.atherosclerosis.2011.03.042

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm2011

    • Author(s)
      Kaneko H, Anzai T, Takahashi T, Kohno T, Shimoda M, Sasaki A, Shimizu H, Nagai T, Maekawa Y, Yoshimura K, Aoki H, Yoshikawa T, Okada Y, Yozu R, Ogawa S, Fukuda K
    • Journal Title

      Cardiovasc Res

      Volume: 91(2) Issue: 2 Pages: 358-367

    • DOI

      10.1093/cvr/cvr080

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大動脈瘤-慢性炎症のモデル疾患2011

    • Author(s)
      青木浩樹, 吉村耕一
    • Journal Title

      医学のあゆみ

      Volume: 236(4) Pages: 271-277

    • Related Report
      2012 Final Research Report
  • [Journal Article] 大動脈瘤/大動脈解離の薬物療法2010

    • Author(s)
      吉村耕一, 森景則保, 青木浩樹
    • Journal Title

      Vascular Lab

      Volume: 7(6) Pages: 48-52

    • Related Report
      2012 Final Research Report
  • [Journal Article] 大動脈瘤の非手術治療は可能か2010

    • Author(s)
      吉村耕一
    • Journal Title

      Heart View

      Volume: 14(9) Pages: 94-97

    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular Pathogenesis of Abdominal Aortic Aneurysm2013

    • Author(s)
      Yoshimura K
    • Organizer
      Seminor in Karolinska institutet
    • Place of Presentation
      Stockholm, Sweeden
    • Year and Date
      2013-02-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 大動脈瘤・解離における JNK2 の役割2012

    • Author(s)
      長澤綾子,吉村耕一,山下 修,濱野公一
    • Organizer
      第5回大動脈瘤分子病態研究会
    • Place of Presentation
      久留米 久留米大学
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of Signaling Pathways in Aortic Aneurysms.2012

    • Author(s)
      Yoshimura K
    • Organizer
      3rd International Meeting on Aortic Diseases-New insights into an old problem
    • Place of Presentation
      Liege, Belgium
    • Related Report
      2012 Final Research Report
  • [Presentation] Angiotensin II pathway is critical for MMP-9 production in human thoracic aortic aneurysms2012

    • Author(s)
      Nagasawa A, Yoshimura K, Yamashita O, Tsuchida M, Hamano K
    • Organizer
      3rd International Meeting on Aortic Diseases -New insights into an old problem-.
    • Place of Presentation
      Liege, Belgium
    • Related Report
      2012 Final Research Report
  • [Presentation] Angiotensin II Upregulates Oxidative Stress through Toll-like Receptor 4 by Inhibiting ecSOD and ATP7A2012

    • Author(s)
      Nakashima T, Umemoto S, Yoshimura K, Matsuda S, Fukai T, Matsuzaki M
    • Organizer
      第76回日本循環器学会
    • Place of Presentation
      福岡 福岡国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of JNK2 in Mechanosensing and Proinflammatory Signaling during Development of Aortic Aneurysm2011

    • Author(s)
      Yoshimura K
    • Organizer
      The Scientific Conferenc"Abdominal Aortic Aneurysm: Epidemiology, Genetics, and Patho- physiology
    • Place of Presentation
      Danville, PA, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] Statins reduce NF- κ B Activation and Chemokine Secretion in Human Abdominal Aortic Aneurysm Wall2011

    • Author(s)
      Nagasawa A, Yoshimura K, Aoki H, Hamano K
    • Organizer
      The Scientific Conference "Abdominal Aortic Aneurysm: Epidemiology, Genetics, and Pathophysiology
    • Place of Presentation
      Danville, PA, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] ATII may Activate MCP-1 through the Increase in TLR4-Mediated Oxidative Stress and Induce Cardiac Hypertrophy and Dysfunction2011

    • Author(s)
      Matsuda S, Umemoto S, Yoshino H, Nakashima T, Ito S, Yoshimura K, Murata, T, Matsuzaki M
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜 パシフィコ横浜.
    • Related Report
      2012 Final Research Report
  • [Presentation] JAK/STAT Pathway is Highly Active and Regulates a Subset of Chemokines in Human Abdominal Aortic Aneurysm2011

    • Author(s)
      Ohno S, Aoki H, Nishihara M, Miyamoto T, Yasukawa H, Aoyagi S, Yoshimura K, Hamano K, Shigematsu H, Imaizumi T
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Toll-like receptor signal adaptor protein MyD88 is important in regulating NADPH oxidase-generated oxidative stress and vascular remodeling2011

    • Author(s)
      Nakashima T, Umemoto S, Matsuda S, Okamot T, Murata T, Yoshimura K, Fukai T, Matsuzaki M
    • Organizer
      第43回日本動脈硬化学会
    • Place of Presentation
      札幌 ロイトン札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular network for the homeostasis of aortic tissue2010

    • Author(s)
      Aoki H, Kimura T, Yoshimura K, Imanaka K, Yoshida T, Aonuma K, Hiroe M, Imaizumi Y, Matsuzaki M
    • Organizer
      第18回日本血管生物医学会
    • Place of Presentation
      大阪 梅田スカイビル
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular Pathogenesis of AAA2010

    • Author(s)
      Yoshimura K
    • Organizer
      2nd International Meeting on Aortic Disease -New insights into an old problem
    • Place of Presentation
      Liege, Belgium.
    • Related Report
      2012 Final Research Report
  • [Book] 第3 節大動脈瘤モデル. 疾患モデルの作製と利用-循環器疾患2010

    • Author(s)
      北 徹ら
    • Publisher
      エル・アイ・シー
    • Related Report
      2012 Final Research Report
  • [Book] 大動脈瘤研究の現状と課題. 循環器疾患のサイエンス2010

    • Author(s)
      小室一成
    • Publisher
      南山堂
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~surg-1/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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