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Development of the tools for organ stress and its surgical application

Research Project

Project/Area Number 22659237
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionHokkaido University

Principal Investigator

TODO Satoru  北海道大学, 大学院・医学研究科, 特任教授 (60136463)

Co-Investigator(Kenkyū-buntansha) OZAKI Michitaka  北海道大学, 大学院・保健科学研究院, 教授 (80256510)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,140,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords生体イメージング / 脂肪肝 / 肝ストレス / メタボリック症候群 / 肝障害 / 肝再生 / 光プローブ / 外科的ストレス / 光イメージング / 非侵襲的モニタリング / 動的解析 / ストレス測定 / 分子機能プローブ / 酸化的ストレス / 小胞体ストレス / Akt
Research Abstract

Steatotic liver, very sensitive to various surgical procedures, is associated with post-operative liver failure, impaired regeneration, post-operative infection and sepsis. In the present study, we analyzed whether the surgical stress affects the post-operativeliver function, injury and regeneration of steatotic liver by newly developed optic probes for bio-imaging. We evaluated mouse liver continuously and non-invasively and analyzed the underlying mechanism of post-operative liver injury and impaired regeneration.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (31 results)

All 2013 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (22 results)

  • [Journal Article] Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients2013

    • Author(s)
      Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N, Ozaki M, Shimizu H.J
    • Journal Title

      Allergy Clin Immunol

      Volume: 131(2) Pages: 434-41

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunosuppressive effects of DTCM-G, a novel inhibitor of the mTOR downstreamsignaling pathway2013

    • Author(s)
      Shibasaki S, Yamashita K, Goto R, Wakayama K, Tsunetoshi Y, Zaitsu M, Igarashi R, Haga S, Ozaki M, Umezawa K, Todo S
    • Journal Title

      Transplantation

      Volume: 95(4) Pages: 542-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiological Characteristics of Melanoma In-Transit Metastasis in a Lymphedema Mouse Model2013

    • Author(s)
      Kohei Oashi, Hiroshi Furukawa, Hiroshi Nishihara, Michitaka Ozaki, Akihiko Oyama,Emi Funayama, Toshihiko Hayashi, Yuji Kuge and Yuhei Yamamoto
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 133(2) Pages: 537-544

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Methods of Detecting the Target Molecule in immunohistology using a Bioluminescence Probe. Luminescence2013

    • Author(s)
      Chun Wu, Ke-Yong Wang, Xin Guo, Masanori Sato, Michitaka Ozaki, Shyohei Shimajiri, Yoshihiro Ohmiya, Yasuyuki Sasaguri.
    • Journal Title

      The Journal of Biological and Chemical Luminescence

      Volume: 28(1) Pages: 38-43

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Methods of Detecting the Target Molecule in immunohistology using a Bioluminescence Probe. Luminescence2013

    • Author(s)
      Chun Wu, Ke-Yong Wang, Xin Guo, Masanori Sato, Michitaka Ozaki, Shyohei Shimajiri, Yoshihiro Ohmiya, Yasuyuki Sasaguri
    • Journal Title

      The Journal of Biological and Chemical Luminescence

      Volume: 28 Pages: 38-43

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo monitoring of liver damage by caspase-3 probe2012

    • Author(s)
      Michitaka Ozaki, Sanae Haga, Takeaki Ozawa
    • Journal Title

      Theranostics

      Volume: 2(2) Pages: 207-214

    • NAID

      10031131094

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo monitoring of liver damage by caspase-3 probe.2012

    • Author(s)
      Michitaka Ozaki, Sanae Haga, Takeaki Ozawa
    • Journal Title

      Theranostics

      Volume: 2 Pages: 207-214

    • NAID

      10031131094

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress enhances granulocytic differentiation in HL 60 cells, an acute promyelocytic leukemia cell line2010

    • Author(s)
      Tetsuya Ogino, Michitaka Ozaki, Akihiro Matsukawa
    • Journal Title

      Free Radical Research

      Volume: 44 Pages: 1328-1337

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p66Shc plays a pivotal role in impaired liver regeneration in aged mice by a redox-dependent mechanism2010

    • Author(s)
      Sanae Haga, Naoki Morita, Kaikobad Irani, Masato Fujiyoshi, Tetsuya Ogino, Michitaka Ozaki
    • Journal Title

      Laboratory Investigation

      Volume: 90 Pages: 1718-1726

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] p62/STSQM1 plays a central role in liver injury in steatotic liver during regeneration2012

    • Author(s)
      芳賀早苗、小澤岳昌、森田直樹、梅澤一夫、藤堂省、尾崎倫孝
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡
    • Year and Date
      2012-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] STAT3 plays a pivotal role in cell adhesion in mouse hepatocytes by regulating E-cadherin expression2012

    • Author(s)
      S.Haga, H.Inoue, A.Kano, X.-Y.Fu, K.Terui, M. Ozaki
    • Organizer
      25th European Congress of Pathology
    • Place of Presentation
      Prague Congress Centre,Czecho
    • Related Report
      2011 Final Research Report
  • [Presentation] Bioluminescent imaging of hepatic caspase-3 activity in mice2012

    • Author(s)
      Sanae Haga, Takeaki Ozawa, MichitakaOzaki
    • Organizer
      第14回国際組織細胞化学会議
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Final Research Report
  • [Presentation] 虚血/再灌流傷害における高血糖および脂肪化病態肝の反応性の相違2012

    • Author(s)
      芳賀早苗、小澤岳昌、森田直樹、阿部理一郎、藤堂省、尾崎倫孝
    • Organizer
      第19回肝細胞研究会
    • Place of Presentation
      札幌医科大学臨床教育研究棟講堂
    • Related Report
      2011 Final Research Report
  • [Presentation] Bio-imaging of surgical stress: Dynamic analysis of liver oxidative stress and damage2012

    • Author(s)
      N. Morita, S. Haga, T. Ozawa, S. J.Remington, M. Ozaki
    • Organizer
      17th International Symposium onBioluminescence and Chemiluminescence (ISBC2012)
    • Place of Presentation
      Delta Guelph Hotel & Conference Centre, Guelph, Ontario, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] 「虚血/再灌流傷害における高血糖および脂肪化病態肝の反応性の相違」2012

    • Author(s)
      芳賀早苗、小澤岳昌、森田直樹、阿部理一郎、藤堂省、尾崎倫孝
    • Organizer
      第19回肝細胞研究会
    • Place of Presentation
      札幌医科大学臨床教育研究棟講堂(札幌市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝再生機序解析の現状(正常肝、加齢肝、脂肪肝)2011

    • Author(s)
      尾崎倫孝、芳賀早苗、森田直樹
    • Organizer
      第14回日本肝臓医生物学研究会
    • Place of Presentation
      東京医科歯科大学東京(招待講演)
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular analysis of liver regeneration in mouse: roles of cell proliferation and growth MBSJ20112011

    • Author(s)
      Michitaka Ozaki, Sanae Haga, Hiroshi Inoue, Wataru Ogawa
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of different cellularresponses of cells in hyperglycemic condition or steatotic hepatocytes - a simulated study of stress response in metabolic syndrome - MBSJ20112011

    • Author(s)
      Sanae Haga, Takeaki Ozawa, Takako Aoyama, Naoki Morita, S.James Remington, Riichiro Abe, Michitaka Ozaki
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Age-associated p66Shc induced redox-dependent liver damage and impaired regeneration after hepatectomy in aged mice2011

    • Author(s)
      Michitaka Ozaki, Sanae Haga, Kaikobad Irani, Naoki Morita, Yoshimi Kaneshima, Takeaki Ozawa
    • Organizer
      62th Annual meeting of AASLD, San Francisco, USA
    • Place of Presentation
      Moscone West ConventionCenter
    • Related Report
      2011 Final Research Report
  • [Presentation] 脂肪肝におけるFas過剰発現および細胞内酸化的ストレスによる肝再生不全の検討2011

    • Author(s)
      芳賀早苗,森田直樹,青山貴子,小澤岳昌,RemingtonS.James,阿部理一郎,藤堂省、尾崎倫孝
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Bio-imaging of Surgical Stresses-Dynamic Analyses of Liver Oxidative Stress and Damage2011

    • Author(s)
      M. Ozaki, S. Haga, T. Ozawa, N. Morita, Y. Kaneshima, J. Remington
    • Organizer
      5TH European Conference of the International Federation for Medical andBiologicalEngineering
    • Place of Presentation
      Budapest Congress & World Trade Center, Budapest, Hungary
    • Related Report
      2011 Final Research Report
  • [Presentation] 'Collagen Vitrigel Sheet' as a Novel Drug Delivery Bio- material2011

    • Author(s)
      Sanae Haga, Toshiaki Takezawa, Takeaki Ozawa, James Remington, Naoki Morita and Michitaka Ozaki
    • Organizer
      5TH European Conference of the International Federation for Medical and Biological Engineering
    • Place of Presentation
      Budapest Congress & World Trade Center, Budapest, Hungary
    • Related Report
      2011 Final Research Report
  • [Presentation] 脂肪肝における肝再生不全機序の解析2011

    • Author(s)
      芳賀早苗、森田直樹、小澤岳昌、レミントンジェームズ、藤堂省、尾崎倫孝
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 「脂肪肝におけるFas過剰発現および細胞内酸化的ストレスによる肝再生不全の検討」2011

    • Author(s)
      芳賀早苗,森田直樹,青山貴子,小澤岳昌,Remington S.James,阿部理一郎,藤堂省、尾崎倫孝
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「脂肪肝における肝再生不全機序の解析」2011

    • Author(s)
      芳賀早苗、森田直樹、小澤岳昌、レミントン ジェームズ、藤堂省、尾崎倫孝
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 種々の病態における肝再生の分子制御磯構の解析(細胞増殖・細胞成長・細胞死の観点から)2011

    • Author(s)
      尾崎倫孝、芳賀早苗、森田直樹、金島由実、James Remington、小澤岳昌、井上啓、松本道宏
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Related Report
      2010 Annual Research Report
  • [Presentation] 外科治療による肝細胞ストレスと障害・再生への影響(生体イメージング法をもちいた動的解析2011

    • Author(s)
      尾崎倫孝、芳賀早苗、森田直樹,青山貴子、金島由実、Kaikobad Irani、James Remington
    • Organizer
      第18回肝細胞研究会
    • Place of Presentation
      東京ガーデンパレス
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発光プローブで病理診断に挑む2010

    • Author(s)
      近江谷克裕、呉純、尾崎倫孝
    • Organizer
      第56回日本病理学会秋期特別総会
    • Place of Presentation
      西日本総合展示場福岡(招待講演)
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臓器傷害・防御・再生におけるNFkB、Jak/STAT3、P13-K/PDK1/Aktの役割とその分子メカニズム2010

    • Author(s)
      尾崎倫孝
    • Organizer
      第15回FSRCセミナー
    • Place of Presentation
      鹿児島大学医学部鹿児島(招待講演)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oxidative stress-mediated liver damage and impaired liver regeneration in partial hepatectomy model of fatty mouse2010

    • Author(s)
      Sanae Haga, Naoki Morita, Takeaki Ozawa, Remington S.James, Michitaka Ozaki
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸国際会議場神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of impaired liver regeneration by bio-imaging of oxidative stress-mediated liver damage following partial resection of fatty liver2010

    • Author(s)
      芳賀早苗, 森田直樹, 小澤岳昌, S.James Remington, 尾崎倫孝
    • Organizer
      第19回日本バイオイメージング学会学術集会
    • Place of Presentation
      慶應義塾大学横浜
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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