| Project/Area Number |
22659237
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
TODO Satoru 北海道大学, 大学院・医学研究科, 特任教授 (60136463)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Michitaka 北海道大学, 大学院・保健科学研究院, 教授 (80256510)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,140,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | 生体イメージング / 脂肪肝 / 肝ストレス / メタボリック症候群 / 肝障害 / 肝再生 / 光プローブ / 外科的ストレス / 光イメージング / 非侵襲的モニタリング / 動的解析 / ストレス測定 / 分子機能プローブ / 酸化的ストレス / 小胞体ストレス / Akt |
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| Research Abstract |
Steatotic liver, very sensitive to various surgical procedures, is associated with post-operative liver failure, impaired regeneration, post-operative infection and sepsis. In the present study, we analyzed whether the surgical stress affects the post-operativeliver function, injury and regeneration of steatotic liver by newly developed optic probes for bio-imaging. We evaluated mouse liver continuously and non-invasively and analyzed the underlying mechanism of post-operative liver injury and impaired regeneration.
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