Discovery omics for molecular targeted portal vein embolization and the efficiency of enlargement of the liver

• Project/Area Number: 22659239
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: ONOGAWA Tohru 東北大学, 病院, 助教 (50431557)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 門脈塞栓 / マルチオミクス / 肝細胞 / 肝肥大 / マイクロアレイ / プロテオミクス / メタボロミクス / 分子標的

Research Abstract

Portal vein Branch Ligation model was raised, we examined the liver enlargement rate of non-ligation lobe, and expressions of mRNA and proteins of the target molecule of Nrf2 in Nrf2 knockout mouse, liver specific Keap1 knockout mouse, and wild type. In the wild type showed enlargement of the liver in the non-ligation lobe significant compared to Nrf2 knockout mice. In addition, expression of Nqo1 in non-ligation lobe was significantly increased compared to the ligation lobe.

Research Products

• [Journal Article] Segmentectomy of the liver (2012)
  • Author(s): Yoshida H, Katayose Y, Rikiyama T, Motoi F, Onogawa T, Egawa S, Unno M.
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 19(1) Issue: 1 Pages: 67-71
  • DOI: 10.1007/s00534-011-0448-8
• [Journal Article] Paclitaxel as second-line chemotherapy in patients with gemcitabine-refractory pancreatic cancer : a retrospective study (2011)
  • Author(s): Maeda S, Motoi F, Onogawa T, et al
  • Journal Title: Int J Clin Oncol Volume: 16 Issue: 5 Pages: 539-545
  • DOI: 10.1007/s10147-011-0220-8
  • NAID: 10030246872
  • Peer Reviewed
• [Journal Article] Computed tomography reflected endocrine function of the pancreas (2011)
  • Author(s): Sakata N, Egawa S, Rikiyama T, Yoshimatsu G, Masuda K, Ohtsuka H, Ottomo S, Nakagawa K, Hayashi H, Morikawa T, Onogawa T, Yamamoto K, Yoshida H, Akada M, Motoi F, Naitoh T, Katayose Y, Unno M.
  • Journal Title: J Gastrointest Surg Volume: 15 Issue: 3 Pages: 525-532
  • DOI: 10.1007/s11605-010-1406-5
  • Peer Reviewed
• [Journal Article] A case of hypersensitivity reaction to reintroduced-oxaliplatin at the second course of oxaliplatin-based chemotherapy after neoadjuvantchemotherapy for liver metastases from colon cancer (2011)
  • Author(s): Katayose Y, et al
  • Journal Title: Gan To Kagaku Ryoho Volume: 38(13) Pages: 2651-3
  • Peer Reviewed
• [Journal Article] A case of distal cholangiocarcinoma with high sensitivity toneoadjuvant chemoradiation therapy (2011)
  • Author(s): Haji Y, et al
  • Journal Title: Gan To Kagaku Ryoho Volume: 38(12) Pages: 2426-8
  • Peer Reviewed
• [Journal Article] The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides (2010)
  • Author(s): Abe M, Toyohara T, Ishii A, Suzuki T, Noguchi N, Akiyama Y, Shiwaku HO, Nakagomi-Hagihara R, Zheng G, Shibata E, Souma T, Shindo T, Shima H, Takeuchi Y, Mishima E, Tanemoto M, Terasaki T, Onogawa T, Unno M, Ito S, Takasawa S, Abe T
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 25 Issue: 3 Pages: 274-282
  • DOI: 10.2133/dmpk.25.274
  • NAID: 10027582905
  • ISSN: 1347-4367, 1880-0920
• [Journal Article] Assessment of Frey procedures : Japanese experience (2010)
  • Author(s): Egawa S, Motoi F, Sakata N, Kitamura Y, Nakagawa K, Ohtsuka H, Hayashi H, Morikawa T, Omura N, Ottomo S, Yoshida H, Onogawa T, Yamamoto K, Akada M, Rikiyama T, Katayose Y, Matsuno S, Unno M
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 17(6) Issue: 6 Pages: 745-51
  • DOI: 10.1007/s00534-009-0185-4
• [Journal Article] Assessment of Frey procedures : Japanese experience (2010)
  • Author(s): Egawa S, et al
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 17(6) Pages: 745-751
  • Peer Reviewed
• [Journal Article] The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides (2010)
  • Author(s): Abe M, et al
  • Journal Title: Drug Metab Pharmacokinet Volume: 25(3) Pages: 274-282
  • Peer Reviewed
• [Presentation] Proteomic Forecast of Postoperative Prognosis of Pancreatic Cancer using Formalin-Fixed Paraffin-Embedded Tissue (2011)
  • Author(s): Takadate T, Onogawa T, et al
  • Organizer: American Pancreatic Association Annual Meeting
  • Place of Presentation: Chicago, アメリカ
  • Year and Date: 2011-11-04
• [Presentation] Proteomic Forecast of Postoperative Prognosis of Pancreatic Cancer using Formalin-Fixed Paraffin-Embedded Tissue (2011)
  • Author(s): Takadate T, Onogawa T, et al
  • Organizer: American Pancreatic Association Annual Meeting 2011
  • Place of Presentation: Chicago,アメリカ
  • Year and Date: 2011-11-04
• [Presentation] 膵癌診療情報アーカイブとFFPE組織プロテオーム解析からの外科治療抵抗性予測 (2011)
  • Author(s): 高舘達之, 小野川徹
  • Organizer: 第16回日本外科病理学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-29
• [Presentation] 胆管癌FFPE組織からの癌特異的プロテオーム解析データに基づく新規診断戦略 (2011)
  • Author(s): 前田晋平, 小野川徹
  • Organizer: 第16回日本外科病理学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-29
• [Presentation] Discovery Proteomics using Formalin-Fixed Paraffin-Embedded Tissues of Cholangiocarcinoma (2010)
  • Author(s): 前田晋平, 小野川徹, ら
  • Organizer: 第69回日本癌学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Discovery Proteomics using Formalin-Fixed Paraffin-Embedded Tissues of Cholangiocarcinoma (2010)
  • Author(s): 前田晋平, 小野川徹
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-12
• [Presentation] Proteomic Analysis of Pancreatic Cancer Prognosis using Formalin-Fixed Paraffin-Embedded Tissue (2010)
  • Author(s): 高舘達之, 小野川徹
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-12
• [Presentation] ホルマリン固定パラフィン包埋(FFPE)組織切片の臨床プロテオーム解析における基礎パラメータの検討 (2010)
  • Author(s): 小野川徹, ら
  • Organizer: 日本プロテオーム学会2010年会・第6回日本臨床プロテオーム研究会連合大会
  • Place of Presentation: 浦安
  • Year and Date: 2010-07-27
• [Presentation] 胆道癌FFPE組織を用いた網羅的プロテオーム解析による新規バイオマーカーの探索と検証 (2010)
  • Author(s): 前田晋平, 小野川徹, ら
  • Organizer: 日本プロテオーム学会2010年会・第6回日本臨床プロテオーム研究会連合大会
  • Place of Presentation: 浦安
  • Year and Date: 2010-07-27
• [Presentation] FFPE組織を用いたレトロスペクティブプロテオミクスによる膵癌新規予後予測マーカーの探索 (2010)
  • Author(s): 高舘達之, 小野川徹, ら
  • Organizer: 日本プロテオーム学会2010年会・第6回日本臨床プロテオーム研究会連合大会
  • Place of Presentation: 浦安
  • Year and Date: 2010-07-27
• [Presentation] 胆道癌FFPE組織を用いた網羅的プロテオーム解析による新規バイオマーカーの探索と検証 (2010)
  • Author(s): 前田晋平, 小野川徹
  • Organizer: 日本プロテオーム学会2010年会・第6回日本臨床プロテオーム研究会連合大会
  • Place of Presentation: 舞浜
  • Year and Date: 2010-07-26
• [Presentation] ホルマリン固定パラフィン包埋(FFPE)組織切片の臨床プロテオーム解析における基礎パラメータの検討-JHUPO FFPE (2010)
  • Author(s): 小野川徹, 高舘達之
  • Organizer: Clinical Proteome Initiative-日本プロテオーム学会2010年会・第6回日本臨床プロテオーム研究会連合大会
  • Place of Presentation: 舞浜
  • Year and Date: 2010-07-26
• [Presentation] The effectiveness of paclitaxel for gemcitabine-refractory pancreatic cancer (2010)
  • Author(s): S.Maeda, F.Motoi, et al
  • Organizer: Joint Meeting-of IAP and JPS 2010
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-07-13
• [Presentation] Discovery of Prognostic Factor using Proteomic Analysis with Formalin-Fixed Paraffin-Embedded Tissues of Pancreatic Cancer (2010)
  • Author(s): Takadate T, Onogawa T, Motoi F, et al
  • Organizer: 第14回国際膵臓学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-07-11
• [Presentation] The effectiveness of paclitaxel for gemcitabine-refractory pancreatic cancer (2010)
  • Author(s): Maeda S, Motoi F, Onogawa T, et al
  • Organizer: 第14回国際膵臓学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-07-11
• [Presentation] Discovery of Prognostic Factor using Proteomic Analysis with Formalin-Fixed Paraffin-Embedded Tissues of Pancreatic Cancer (2010)
  • Author(s): Takadate T, Onogawa T, et al
  • Organizer: Joint Meeting of IAP and JPS 2010
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-07-11
• [Presentation] 病院保管のホルマリン固定化永久組織からプロテオーム解析はどこまでできるか?～ナノテクノロジーによるTissue to serum & bile strategy～ (2010)
  • Author(s): 小野川徹, ら
  • Organizer: 第22回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-27
• [Patent(Industrial Property Rights)] 膵臓癌診断・予後予測バイオマーカ (2011)
  • Inventor(s): 小野川徹、海野倫明、元井冬彦、高舘達之
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Filing Date: 2011-06-21
• [Patent(Industrial Property Rights)] 胆道癌診断バイオマーカー (2011)
  • Inventor(s): 小野川徹、海野倫明、前田晋平
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Industrial Property Number: 2011-107624
  • Filing Date: 2011-05-12
• [Patent(Industrial Property Rights)] 胆道癌マーカー (2011)
  • Inventor(s): 小野川徹, ら
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2011-107624
  • Filing Date: 2011-05-12
• [Patent(Industrial Property Rights)] 膵臓癌マーカー (2011)
  • Inventor(s): 小野川徹, ら
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2011-137320
  • Filing Date: 2011-06-21