Discovery omics for molecular targeted portal vein embolization and the efficiency of enlargement of the liver
| Project/Area Number |
22659239
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | 門脈塞栓 / マルチオミクス / 肝細胞 / 肝肥大 / マイクロアレイ / プロテオミクス / メタボロミクス / 分子標的 |
|---|
| Research Abstract |
Portal vein Branch Ligation model was raised, we examined the liver enlargement rate of non-ligation lobe, and expressions of mRNA and proteins of the target molecule of Nrf2 in Nrf2 knockout mouse, liver specific Keap1 knockout mouse, and wild type. In the wild type showed enlargement of the liver in the non-ligation lobe significant compared to Nrf2 knockout mice. In addition, expression of Nqo1 in non-ligation lobe was significantly increased compared to the ligation lobe.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Computed tomography reflected endocrine function of the pancreas2011
Author(s)
Sakata N, Egawa S, Rikiyama T, Yoshimatsu G, Masuda K, Ohtsuka H, Ottomo S, Nakagawa K, Hayashi H, Morikawa T, Onogawa T, Yamamoto K, Yoshida H, Akada M, Motoi F, Naitoh T, Katayose Y, Unno M.
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Journal Title
J Gastrointest Surg
Volume: 15
Issue: 3
Pages: 525-532
DOI
Related Report
Peer Reviewed
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[Journal Article] The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides2010
Author(s)
Abe M, Toyohara T, Ishii A, Suzuki T, Noguchi N, Akiyama Y, Shiwaku HO, Nakagomi-Hagihara R, Zheng G, Shibata E, Souma T, Shindo T, Shima H, Takeuchi Y, Mishima E, Tanemoto M, Terasaki T, Onogawa T, Unno M, Ito S, Takasawa S, Abe T
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Journal Title
Drug Metabolism and Pharmacokinetics
Volume: 25
Issue: 3
Pages: 274-282
DOI
NAID
ISSN
1347-4367, 1880-0920
Related Report
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[Journal Article] Assessment of Frey procedures : Japanese experience2010
Author(s)
Egawa S, Motoi F, Sakata N, Kitamura Y, Nakagawa K, Ohtsuka H, Hayashi H, Morikawa T, Omura N, Ottomo S, Yoshida H, Onogawa T, Yamamoto K, Akada M, Rikiyama T, Katayose Y, Matsuno S, Unno M
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 17(6)
Issue: 6
Pages: 745-51
DOI
Related Report
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