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The study to clarify a mechanism of replacing growth of the hepatocellular carcinoma using the adipose tissue derived stem cells

Research Project

Project/Area Number 22659243
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionThe University of Tokushima

Principal Investigator

SHIMADA Mitsuo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10216070)

Co-Investigator(Kenkyū-buntansha) UTSUNOMIYA Tohru  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30304801)
IMURA Satoru  徳島大学, 病院, 助教 (90380021)
MORINE Yuji  徳島大学, 病院, 助教 (60398021)
IKEMOTO Tetsuya  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (20398019)
BANDO Yoshimi  徳島大学, 病院, 准教授 (00238239)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,290,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords肝細胞癌 / 置換性発育 / 脂肪幹細胞 / 癌幹細胞
Research Abstract

We investigated the role of the adipose tissue-derived stem cells(ADSC) in replacing growth of hepatoccellar carcinoma(HCC). HCC cell line(HuH7) and ADSC were co-cultured with or without cell-cell contact to clarify whether mediator affected HCC cell growth. And we concluded cell contact was important process in cell growth during co-culture HCC cells with ADSC. In addition, immunohistochemical staining of stemness marker(CD44 and CD133) and junction protein(Connexin 32) was performed in eleven well differentiated HCC patients with replacing growth. No positive cells were recognized in the invasive front area, however, junction protein(Cx32) was expressed at peripheral area in cytoplasm.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (22 results)

  • [Journal Article] Role of histone deacetylase expression in intrahepatic cholangiocarcinoma2012

    • Author(s)
      Morine Y, Shimada M, Utsunomiya T, et al.
    • Journal Title

      Surgery

      Volume: 151(3) Pages: 412-419

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of pegylated interferonα2b on metastasis of hepatocellular carcinoma2012

    • Author(s)
      Arakawa Y, Shimada M, Utsunomiya T, et al.
    • Journal Title

      J Surg Res

      Volume: 172(1) Pages: 95-101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA in intrahepatic cholangiocarcinoma2012

    • Author(s)
      Morine Y, Shimada M, Utsunomiya T, et al.
    • Journal Title

      Surg Today

      Volume: 42(2) Pages: 135-140

    • NAID

      10030230687

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma2012

    • Author(s)
      Morine Y, Shimada M, Utsunomiya T, et al.
    • Journal Title

      Surg Today

      Volume: 42(2) Pages: 147-151

    • NAID

      10030230747

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of thymidine synthase and dihydropyrimidine dehydrogenase mRNA expressions in gallbladder carcinoma2012

    • Author(s)
      Iwahashi S, Shimada M, Utsunomiya T, et al.
    • Journal Title

      Surg Today

      Volume: 42(6) Pages: 565-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of hepatectomy in super-elderly patients with hepatocellular carcinoma2012

    • Author(s)
      Yamada S, Shimada M, Utsunomiya T, et al.
    • Journal Title

      Hepatol res

      Volume: (in press) Issue: 5 Pages: 454-458

    • DOI

      10.1111/j.1872-034x.2011.00952.x

    • NAID

      10031144259

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of pegylated interferon α2b on metastasis of hepatocellular carcinoma2012

    • Author(s)
      Arakawa Y, et al
    • Journal Title

      J Surg Res

      Volume: 172(1) Pages: 95-101

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of thymidine synthase and dihydropyrimidine dehydrogenase mRNA expressions in gallbladder carcinoma2012

    • Author(s)
      Iwahashi S, et al
    • Journal Title

      Sure Today

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of hepatectomy in super-elderly patients with hepatocellular carcinoma2012

    • Author(s)
      Yamada S, et al
    • Journal Title

      Hepatol Res

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human adipose-derived stem cells : potential clinical applications in surgery2011

    • Author(s)
      Utsunomiya T, Shimada M, Imura S, et al.
    • Journal Title

      Surg Today

      Volume: 41(1) Pages: 18-23

    • NAID

      10027818310

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-αon pancreatic cancer cells2011

    • Author(s)
      Iwahashi S, Shimada M, Utsunomiya T, et al.
    • Journal Title

      Int J Clin Oncol

      Volume: 16(6) Pages: 671-678

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia inducible factor expression in intrahepatic colangiocarcinoma2011

    • Author(s)
      Morine Y, Shimada M, Utsunomiya T, et al.
    • Journal Title

      Hepatogastroenterology

      Volume: 58(110-111) Pages: 1439-1444

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylase inhibitor enhances the anti-tumor effect of gemcitabine : a special reference to gene-expression microarray analysis2011

    • Author(s)
      Iwahashi S, Shimada M, Utsunomiya T, et al.
    • Journal Title

      Oncol Rep

      Volume: 26(5) Pages: 1057-1062

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human adipose-derived stem cells : potential clinical applications in surgery2011

    • Author(s)
      Utsunomiya T, et al
    • Journal Title

      Sure Today

      Volume: 41(1) Pages: 18-23

    • NAID

      10027818310

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylase inhibitor augments anti-tumor effect of gemcitabine and pegylated interferon-α on pancreatic cancer cells2011

    • Author(s)
      Iwahashi S, et al
    • Journal Title

      Int J Clin Oncol

      Volume: 16(6) Pages: 671-678

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human adipose-derived stem cells : potential clinical applications in surgery.2011

    • Author(s)
      Utsunomiya T.
    • Journal Title

      Surgery Today

      Volume: 41(1) Pages: 18-23

    • NAID

      10027818310

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma.2010

    • Author(s)
      Utsunomiya T.
    • Journal Title

      Journal of Gastroenterology

      Volume: 45(2) Pages: 146-152

    • NAID

      10027214321

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Beneficial effects of adiose-derived stem cells on severe hepatic damage due to hepatectomy and ischemia reperfusion injury in mice2011

    • Author(s)
      Yu Saito
    • Organizer
      21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologists(IASGO 2011)
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Beneficial effects of adiose-derived stem cells on severe hepatic damage due to hepatectomy and ischemia reperfusion injury in mice2011

    • Author(s)
      Yu Saito
    • Organizer
      21st World Congress of the International Association of surgeons, Gastroenterologists and Oncologists (IASGO 2011)
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト脂肪由来幹細胞による肝虚血再灌流障害軽減効果に関する基礎的検討2011

    • Author(s)
      齋藤裕
    • Organizer
      第47回日本移植学会総会
    • Place of Presentation
      仙台国際センター(宮城)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト脂肪由来幹細胞による肝虚血再灌流障害軽減効果に関する基礎的検討2011

    • Author(s)
      齋藤裕
    • Organizer
      第47回日本移植学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝虚血再灌流傷害におけるヒト脂肪由来幹細胞ホーミング効果の機序解明2011

    • Author(s)
      齋藤裕
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 肝虚血再灌流傷害におけるヒト脂肪由来幹細胞ホーミング効果の機序解明2011

    • Author(s)
      齋藤裕
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] The possibility of adipose-derived stem cells for an alternative therapy for liver failure2011

    • Author(s)
      Yu Saito
    • Organizer
      12^<th> Congress of the Asian Society of Transplantation(CAST2011)
    • Place of Presentation
      COEX Seoul(Seoul)
    • Year and Date
      2011-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] The possibility of adipose-derived stem cells for an alternative therapy for liver failure2011

    • Author(s)
      Yu Saito
    • Organizer
      12th Congress of the Asian Society of Transplantation
    • Place of Presentation
      COEX Seoul (Seoul)
    • Year and Date
      2011-09-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] The possibility of adipose-derived regenerative cells for an alternative therapy for liver failure2011

    • Author(s)
      Hiroki Mori
    • Organizer
      European Society for Organ Transplantation(ESOT2011)
    • Place of Presentation
      The Scottish Exhibition and Conference Centre(Glasgow)
    • Year and Date
      2011-09-05
    • Related Report
      2011 Final Research Report
  • [Presentation] The possibility of adipose-derived regenerative cells for an alternative therapy for liver failure2011

    • Author(s)
      Hiroki Mori
    • Organizer
      European Society for Organ Transplantation (ESOT2011)
    • Place of Presentation
      The Scottish Exhibition and Conference Centre (Glasgow)
    • Year and Date
      2011-09-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト脂肪由来幹細胞による肝再生療法に関する基礎的検討2011

    • Author(s)
      齋藤裕
    • Organizer
      第23回日本肝胆膵外科学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト脂肪由来幹細胞による肝再生療法に関する基礎的検討2011

    • Author(s)
      齋藤裕
    • Organizer
      第23回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 非B非C型肝癌再発に対する分子遺伝学的治療戦略-遺伝子およびmiRNA発現のハイブリッド解析から-2011

    • Author(s)
      居村暁
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィックLE DAIBA(東京)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 非B非C型肝癌再発に対する分子遺伝学的治療戦略~遺伝子およびmiRNA発現のハイブリッド解析から~2011

    • Author(s)
      居村暁
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィックLEDAIBA(東京都)
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌幹細胞のepigenetic修飾と癌根治療法への可能性2011

    • Author(s)
      森根裕二
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 癌幹細胞のepigenetic修飾と癌根治療法への可能性2011

    • Author(s)
      森根裕二
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ischemia reperfusion injury enhances SDF1 expressions and homing of adipose derived stem cells2011

    • Author(s)
      Yu Saito
    • Organizer
      8^<th> International Smposium on Minimal Residual Cancer(ISMRC2011)
    • Place of Presentation
      Osaka international convention center(Osaka)
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of histone deacetylase expression in intrahepatic cholangiocarcinoma2011

    • Author(s)
      Yuji Morine
    • Organizer
      102^<nd> American Association for Cancer Research(AACR 2011)
    • Place of Presentation
      Orange County Convention Center(Orlando)
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of histone deacetylase expression in intrahepatic cholangiocarcinoma2011

    • Author(s)
      Yuji Morine
    • Organizer
      102nd American Association for Cancer Research (AACR)
    • Place of Presentation
      Orange County Convention Center (Orlando)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ischemia reperfusion injury enhances SDF1 expressions and homing of adipose derived stem cells2011

    • Author(s)
      Yu Saito
    • Organizer
      8th International Smposium on Minimal Residual Cancer
    • Place of Presentation
      Osaka international convention center (Osaka)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 臨床病理学的および分子遺伝学的特徴からみた非B非C肝癌発生のメカニズム2010

    • Author(s)
      宇都宮徹
    • Organizer
      第21回日本消化器癌発生学会総会
    • Place of Presentation
      軽井沢プリンスホテル(北佐久郡)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adipose tissue derived regenerative cells can differentiate into hepatocytes in regenerating liver after hepatectomy in mice.2010

    • Author(s)
      Saito Y.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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