| Project/Area Number |
22659245
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIRABE Ken 九州大学, 医学研究院, 准教授 (70264025)
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| Co-Investigator(Kenkyū-buntansha) |
MAEHARA Yoshihiko 九州大学, 医学研究院, 教授 (80165662)
TOSHIMA Takeo 九州大学, 大学病院, 医員 (40608965)
武冨 紹信 九州大学, 大学病院, 講師 (70363364)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 肝臓外科学 / オートファジー / 肝再生 / 肝切除 / 肝機能 / 細胞老化 / ATP / 肝細胞癌 / 肝切除術 |
|---|
| Research Abstract |
This research project has revealed that the autophagy of hepatocytes play important role in energy production during liver regeneration. The impairment of autophagy induces cell cycle arrest of hepatocytes and apoptosis, dysfunction of mitochondria. Thereafter hepatocyte hypertrophy occurs and this may due to cell scenesence of hepatocytes.
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