| Project/Area Number |
22659252
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
UENO Takayoshi 大阪大学, 医学系・研究科, 講師 (60437316)
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Yoshiki 大阪大学, 医学系・研究科, 教授 (00243220)
KURATANI Toru 大阪大学, 医学系・研究科, 准教授 (90448035)
SAKAGUCHI Taichi 大阪大学, 医学系・研究科, 寄附講座准教授 (10467574)
SHIRAKAWA Yukitoshi 大阪大学, 医学系・研究科, 助教 (20457013)
YOSHIKAWA Yasushi 大阪大学, 医学部附属病院, 助教 (40570594)
YAMAUCHI Takashi 大阪大学, 医学系・研究科, 助教 (20527999)
SHIMAMURA Kazuo 大阪大学, 医学系・研究科, 寄附講座助教 (10507205)
宮川 繁 大阪大学, 医学系研究科, 助教 (70544237)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,290,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 先天性心疾患 / 循環器・高血圧 / シュミレーション工学 / 血流評価 / Phase contrast MRI / シミュレーション / 循環・高血圧 / シミュレーション工学 |
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| Research Abstract |
With the recent advancement of imaging technology in the medical field, more sophisticated information are now at our hand. Application of novel imaging modality into establishing computational model to simulate the outcome of cardiac surgery is envisioned. Among various factors, blood flow velocity is one of the key components in establishing the hydrodynamic model simulating the circulatory physiology of specific cardiac defects. The novel phase contrast cardiac magnetic resonance imaging(PC-CMR) technique enables the measurement of blood flow velocity at any point of interests in human. Hence, we investigated the possibility of PC-CMR in evaluating the hydrodynamics in patients with Fontan physiology. The study revealed that, compared with normal circulation, Fontan physiology is liable to have,# 1 : less cardiac output with higher systemic flow resistance,# 2 : more systemic to pulmonary collateral flow volume in association with higher systemic resistance,# 3 : more atrio-ventricular valve regurgitation,# 4 : more collateral flow volume, which correlated with degree of cyanosis as well as with age at Fontan operation. Thus, PC-CMR is highly informative in simulating and analyzing the specific circulation physiology, as well as estimating the outcome of cardiac surgery.
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