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Development of a implantable medical device with the self-curable NC-hydrogel.

Research Project

Project/Area Number 22659255
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MIZUNO Toshihide  独立行政法人国立循環器病研究センター, 研究所, 室長 (40426515)

Co-Investigator(Renkei-kenkyūsha) HARAGUCHI Kazutoshi  独立行政法人国立循環器病研究センター, 研究所, 部長 (10373391)
TSUKIYA Tomonori  独立行政法人国立循環器病研究センター, 研究所・人工臓器部, 室長 (00311449)
HONMA Akihiko  東京電機大学, 工学部, 教授 (20287428)
TAKEWA Yoshiaki  独立行政法人国立循環器病研究センター, 研究所・人工臓器部, 室長 (20332405)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,240,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Keywordsヒドロゲル / 人工血管 / 人工弁 / 医療部材 / 生物学的安全性 / 滅菌性 / 生体材料 / ナノコンポジット型ヒドロゲル
Research Abstract

Recently, the demand of wet soft materials for bio-related applications has been increasing. Thus far, we have developed a novel nanocomposite hydrogel (NC gel) with extraordinary mechanical, optical, and swelling/deswelling properties by extending the concept of organic/inorganic NCs to soft hydrogels. In this study, we aimed to develop novel NC gel materials and devices for biomedical applications, such as an implantable material with long-term durability, by improving the functions of the NC gel (e.g. extensibility, absorption of plasma, biological safety, nonconcrescence, and asepsis) and fabricating it in various forms. We succeeded in improving its mechanical, surface, and swelling/deswelling properties by modifying its network.
(2) With regard to the development of new devices, we used NC gel-medical materials. We concluded that NC gels comfortably were able to use as the durable implanted material while simultaneously preventing the formation of intractable granulomatous tissues. Further, we carried out an in vivo investigation of the interaction of living tissue with the NC gel by implantation in goats. We found that neither inflammation nor concrescence occurred around the NC gels.
(3) With regard to the safety and product design of medical devices, we carried out biological testing of medical devices, which involved a sensitization test, irritation test, intracutaneous test, and in vitro cytotoxicity test. We confirmed the safety of the NC gel in all these tests.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2013 2012 2011 2010

All Journal Article (1 results) Presentation (6 results)

  • [Journal Article] トロンボエラストメトリー法を用いた抗血栓性コーティングの定量的評価方法の検討2011

    • Author(s)
      水野敏秀
    • Journal Title

      第50回日本生体医工学学会大会プログラム抄録集

      Volume: (CD-ROM)

    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗血栓性コーティングの性能及び特性の定量的評価法の検討2013

    • Author(s)
      水野秀敏 他
    • Organizer
      人工心臓と補助循環懇談会学術集会
    • Place of Presentation
      山之内町, 長野
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗血栓性コーティングの性能及び特性の定量的評価法の検討2013

    • Author(s)
      水野敏秀
    • Organizer
      人工心臓と補助循環懇話会学術集会 (41)
    • Place of Presentation
      山ノ内町
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗血栓コーティングの性能及び特性の定量的評価法の検討2012

    • Author(s)
      水野秀敏 他
    • Organizer
      バイオマテリアル学会シンポジウム
    • Place of Presentation
      仙台市, 宮城県
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗血栓性コーティングの性能及び特性の定量的評価法の検討2012

    • Author(s)
      水野敏秀
    • Organizer
      バイオマテリアル学会シンポジウム
    • Place of Presentation
      仙台市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nanocomposite hydrogels : a novel Wound dressings, The 3rd International Conference on BioMedical Engineering and Informatics2010

    • Author(s)
      Y.M. Zhou, T MIZUNO et al
    • Organizer
      BMEI'10
    • Place of Presentation
      Yantai, China
    • Year and Date
      2010-10-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Nanocomposite hydrogels : a novel Wound dressings2010

    • Author(s)
      Y.M.Zhou, T MIZUNO, et al
    • Organizer
      The 3rd International Conference on BioMedical Engineering and Informatics (BMEI'10)
    • Place of Presentation
      Yantai, China.
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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