• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prediction of cerebral aneurysmal rupture using magnetic resonance imaging

Research Project

Project/Area Number 22659257
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionShiga University of Medical Science

Principal Investigator

NOZAKI Kazuhiko  滋賀医科大学, 医学部, 教授 (90252452)

Co-Investigator(Kenkyū-buntansha) INUBUSHI Toshirou  滋賀医科大学, MR 医学総合研究センター, 教授 (20213142)
SHIINO Akihino  滋賀医科大学, MR 医学総合研究センター, 准教授 (50215935)
YOKOI Toshihiro  滋賀医科大学, 医学部, 助教 (20573182)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,340,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords未破裂脳動脈瘤 / 動物モデル / 薬物治療 / MR画像 / 分子イメージング / MR画像 / 脳動脈瘤 / くも膜下出血 / MR
Research Abstract

The purpose of this project is to assess cerebral aneurysms sequentially with MR imaging in rat and monkey models and to evaluate the risk of cerebral aneurysm rupture using cell imaging.The protocols of MR imaging for cerebral aneurysms in rats and monkeys were established and preliminary data for cell imaging was obtained.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 9 results) Presentation (15 results) Book (3 results)

  • [Journal Article] 実験的脳動脈瘤からの考察2013

    • Author(s)
      横井俊浩、野崎和彦
    • Journal Title

      Clinical Neuroscience 31

      Pages: 414-416

    • Related Report
      2012 Final Research Report
  • [Journal Article] 未破裂脳動脈瘤の基礎病理と保存的治療の展望 Annual Review 神経2013

    • Author(s)
      横井俊浩、野崎和彦
    • Journal Title

      中外医学社

      Pages: 129-135

    • Related Report
      2012 Final Research Report
  • [Journal Article] 未破裂脳動脈瘤の基礎病理と保存的治療の展望2013

    • Author(s)
      横井俊浩
    • Journal Title

      Annual Review神経

      Volume: 2013 Pages: 129-135

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 動脈硬化に関する研究と今後の展開 脳動脈瘤研究と薬物治療2012

    • Author(s)
      横井俊浩,齊藤実,吉村弥生,野崎和彦
    • Journal Title

      滋賀医科大学雑誌(電子ジャーナル版)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 未破裂脳動脈瘤に対する薬物療法2012

    • Author(s)
      青木友浩、野崎和彦
    • Journal Title

      神経疾患最新の治療

      Volume: 巻頭トピックス Pages: 6-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inadequate communication between patients with unruptured cerebral aneurysms2012

    • Author(s)
      Saito M
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 52 Pages: 873-877

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-arterial infusion therapy for cerebral vasospasm: promising but preliminary2012

    • Author(s)
      Nozaki K
    • Journal Title

      World Neurosurgery

      Volume: 78 Pages: 223-225

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence-based guidelines for the management of aneurysmal subarachnoid2012

    • Author(s)
      Yoshimine T
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 52 Pages: 355-429

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort2012

    • Author(s)
      UCAS Japan Research Group
    • Journal Title

      N Engl J Med

      Volume: 366 Issue: 26 Pages: 2474-2482

    • DOI

      10.1056/nejmoa1113260

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳動脈瘤予防とスタチン2011

    • Author(s)
      青木友浩、野崎和彦
    • Journal Title

      脳神経外科速報

      Volume: 21 Pages: 64-71

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 脳動脈瘤の発生増大のメカニズム2011

    • Author(s)
      横井俊浩、青木友浩、齋藤実、野崎和彦
    • Journal Title

      医学のあゆみ

      Volume: 236 Pages: 107-115

    • Related Report
      2012 Final Research Report
  • [Journal Article] PGE(2)-EP(2) receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying2011

    • Author(s)
      Aoki T, Nozaki K, et al
    • Journal Title

      Br J Pharmacol

      Volume: 163 Pages: 1237-1249

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PGE(2)-EP(2) receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB.2011

    • Author(s)
      Aoki T, et al
    • Journal Title

      Br J Pharmacol.

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS.2011

    • Author(s)
      Aoki T, et al
    • Journal Title

      Lab Invest

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞外基質の産生分解から見た脳動脈瘤増大機構の解析と治療への展望2010

    • Author(s)
      青木友浩、西村真樹、片岡大治、石橋良太、森下竜一、野崎和彦、橋本信夫、宮本享
    • Journal Title

      脳卒中

      Volume: 32 Pages: 538-543

    • NAID

      10027895602

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳動脈瘤治療薬としてのスタチン製剤の可能性2010

    • Author(s)
      青木友浩、西村真樹、野崎和彦、宮本享
    • Journal Title

      脳と循環

      Volume: 15 Pages: 207-211

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] 脳動脈瘤と炎症2010

    • Author(s)
      横井俊浩、青木友浩、野崎和彦
    • Journal Title

      Clinical Neuroscience

      Volume: 28 Pages: 938-940

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] 脳動脈瘤発生・増大のメカニズム2010

    • Author(s)
      横井俊浩、野崎和彦
    • Journal Title

      脳神経外科

      Volume: 38 Pages: 787-793

    • Related Report
      2010 Annual Research Report
  • [Presentation] カニクイザルを用いた実験的脳動脈瘤形成とスタチンによる抑制効果の検証(第一報)2013

    • Author(s)
      斉藤実、横井俊浩、椎野顕彦、野崎和彦
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] TNF-a 阻害剤による脳動脈瘤形成に対する抑制効果の検討2013

    • Author(s)
      横井俊浩、斉藤実、椎野顕彦、野崎和彦、他
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] カニクイザルを用いた実験的脳動脈瘤形成とスタチンによる抑制効果の検証2013

    • Author(s)
      野崎和彦
    • Organizer
      第38回日本脳卒中学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] TNFa阻害薬による脳動脈瘤形成に対する抑制効果の検討2013

    • Author(s)
      野崎和彦
    • Organizer
      第38回日本脳卒中学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳動脈瘤の成因から見た薬物療法の可能性2011

    • Author(s)
      野崎和彦
    • Organizer
      第20回日本脳ドック学会総会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Vascular reconstruction deviceを使用した脳動脈瘤治療の初期経験2011

    • Author(s)
      中澤拓也
    • Organizer
      第17回日本血管内治療学会総会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳動脈瘤 基礎と臨床2011

    • Author(s)
      野崎和彦
    • Organizer
      第34回香川脳血管障害研究会
    • Place of Presentation
      全日空ホテル クレメント高松(香川)(招待講演)
    • Year and Date
      2011-03-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endovascular treatment of ruptured vertebral dissecting artery aneurysms invloving posterior inferior cerebellar artery2011

    • Author(s)
      Nakazawa T
    • Organizer
      35th European Society of Neuroradiology Annual Meeting
    • Place of Presentation
      Belgium
    • Related Report
      2011 Annual Research Report
  • [Presentation] 非出血性椎骨動脈解離性動脈瘤の治療2011

    • Author(s)
      中澤拓也
    • Organizer
      日本脳神経外科学会第70回学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Vascular reconstruction deviceを使用した脳動脈瘤治療2011

    • Author(s)
      中澤拓也
    • Organizer
      第27回日本脳神経血管内治療学会学術総会
    • Place of Presentation
      千葉
    • Related Report
      2011 Annual Research Report
  • [Presentation] HMG-CoA還元酵素阻害薬服用によるくも膜下出血抑制に関するケース・コントロール研究-中間報告-2011

    • Author(s)
      吉村弥生
    • Organizer
      第36回日本脳卒中学会総会(STROKE2011)
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳動脈瘤 基礎と臨床2010

    • Author(s)
      野崎和彦
    • Organizer
      第8回奈良脳卒中サロン
    • Place of Presentation
      ホテルモントレグラスミヤ大阪(大阪)(招待講演)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳動脈瘤 基礎と臨床2010

    • Author(s)
      野崎和彦
    • Organizer
      第38回大阪大学脳神経外科同窓会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)(招待講演)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳動脈瘤2010

    • Author(s)
      野崎和彦
    • Organizer
      山口脳卒中セミナー
    • Place of Presentation
      山口大学(山口)(招待講演)
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular and genetic analysis for cerebral aneurysms2010

    • Author(s)
      Nozaki K
    • Organizer
      2010 Congress of Neurological Surgeons Annual Meeting
    • Place of Presentation
      San Francisco(アメリカ)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Book] 脳神経外科学2012

    • Author(s)
      太田富雄
    • Total Pages
      2586
    • Publisher
      Kinpodo
    • Related Report
      2012 Annual Research Report
  • [Book] モデル動物利用マニュアル2011

    • Author(s)
      横井俊浩、野崎和彦
    • Publisher
      脳動脈瘤(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] モデル動物利用マニュアル」シリーズ 「疾患モデルの作製と利用-循環器疾患」2010

    • Author(s)
      横井俊浩、野崎和彦
    • Publisher
      エルアイシー
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi