Single Cell Tracking of Glioma Invasion using MRI Reporter Gene.
| Project/Area Number |
22659259
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
ARITA Hideyuki 大阪大学, 大学院・医学系研究科, 招へい研究員 (60570570)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Manabu 大阪大学, 大学院・医学系研究科, 助教 (40448064)
YOSHIOKA Yoshichika 大阪大学, 免疫学フロンティア研究センター, 特任教授 (00174897)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | MRI / レポーター遺伝子 / 神経膠芽腫 / 膠芽腫 |
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| Research Abstract |
We have attempted to elucidate the mechanism of glioblastoma cell brain infiltration by use of an MRI reporter gene ; MagA. By overexpressing MagA in glioblastoma cells, it is possible to perform in vivo imaging of these cell by use of MRI. In this study, we were able to establish a MagA-overexpressing glioblastoma cell line, and those cells were successfully transplanted into the brain of a Balb/ c nude mouse. Tumor expansion was observed on MRI. These results suggest that MagA is a powerful MRI reporter gene that can be used for in vivo MR imaging.
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Report
(3 results)
Research Products
(68 results)
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[Journal Article] A survey of disclosure of diagnosis to patients with glioma in Japan2011
Author(s)
Yamamoto F, Hashimoto N, Kagawa N, Okita Y, Chiba Y, Kijima N, Kinoshita M, Yoshizu K, Fujimoto Y, Hirai K, Yoshimine T
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Journal Title
Int J Clin Oncol
Volume: 16(3)
Issue: 3
Pages: 230-237
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of concomitant temozolomide and radiation therapies on WT1-specific T cells in malignant glioma2010
Author(s)
Chiba Y, Hashimoto N, Tsuboi A, Oka Y, Maruo A, Kinoshita M, Kagawa N, Oji Y, Hosen N, Nishida S, Sugiyama H, Yoshimine T
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Journal Title
Jpn J Clin Oncol
Volume: 40(5)
Pages: 395-403
Related Report
Peer Reviewed
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