Molecular imaging and regeneration of autophagy

• Project/Area Number: 22659260
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Okayama University
• Principal Investigator: ABE Koji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20212540)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,100,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: オートファジー / 分子イメージング / 筋萎縮性側索硬化症 / ALS / SOD1 / 脳梗塞 / LC3 / GFP / autophagy / in vivoイメージング / トランスジェニックマウス / in vivo imaging / MCAO / 蛍光顕微鏡

Research Abstract

To visualize the temporal and spatial changes of autophagy occurred in the pathogenesis of cerebral infarction and amyotrophic lateral sclerosis(ALS), a transgenic mouse expressing a fused protein of an autophagy marker, LC3 and GFP was used for analysis. The changes of autophagy can be successfully visualized in the model mice of cerebral infarction and ALS. This novel research technique is a useful tool for investigating therapies for both diseases.

Research Products

• [Journal Article] In vivo optical imaging of motor neuron autophagy in a mouse model of amyotrophic lateral sclerosis (2011)
  • Author(s): Tian F, Morimoto N, Liu W, Ohta Y, Deguchi K, Miyazaki K, Abe K
  • Journal Title: Autophagy Volume: 7 Pages: 985-992
  • Peer Reviewed
• [Journal Article] In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia inmice (2011)
  • Author(s): Liu N, Shang J, Tian FF, Nishi H, Abe K
  • Journal Title: Brain Res Volume: 1397 Pages: 66-75
  • Peer Reviewed
• [Journal Article] Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion (2011)
  • Author(s): Shang J, Deguchi K, Ohta Y, Liu N, Zhang X, Tian F, Yamashita T, Ikeda Y, Matsuura T, Funakoshi H, Nakamura T, Abe K
  • Journal Title: J Neurosci Res Volume: 89 Pages: 86-95
  • Peer Reviewed
• [Journal Article] Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion (2011)
  • Author(s): Tanaka N, Ikeda Y, Ohta Y, Deguchi K, Tian F, Shang J, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1370 Pages: 246-253
  • Peer Reviewed
• [Journal Article] Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes a type of spinocerebellar ataxia(SCA36) accompanied by motor neuron involvement (2011)
  • Author(s): Kobayashi H, Abe K, Matsuura T, Ikeda Y, Hitomi T, Akechi Y, Habu T, Yang LW, Okuda H, Koizumi A
  • Journal Title: Am J Hum Genet Volume: 89 Pages: 121-130
  • Peer Reviewed
• [Journal Article] Atorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-α (2011)
  • Author(s): Kozuki M, Kurata T, Miyazaki K, Morimoto N, Ohta Y, Ikeda Y, Abe K
  • Journal Title: Brain Res Volume: 1388 Pages: 32-38
  • Peer Reviewed
• [Journal Article] Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice : protection by atorvastatin and pitavastatin (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Morimoto N, Ohta Y, Ikeda Y, Abe K
  • Journal Title: Neuroscience Volume: 197 Pages: 358-368
  • Peer Reviewed
• [Journal Article] Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Panin VL, Morimoto N, Ohta Y, Nagai M, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1371 Pages: 161-170
  • Peer Reviewed
• [Journal Article] Early and progressive impairment of spinal blood flow-glucose metabolism coupling in motor neuron degeneration of ALS model mice autophagy in transgenic mice with a G93A mutant SOD1 gene (2011)
  • Author(s): Miyazaki K, Masamoto K, Morimoto N, Kurata T, Mimoto T, Obata T, Kanno I, Abe K
  • Journal Title: J Cereb Blood Flow Metab Volume: 32 Pages: 456-467
  • Peer Reviewed
• [Journal Article] Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis (2011)
  • Author(s): Miyazaki K, Ohta Y, Nagai M, Morimoto N, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Abe K
  • Journal Title: J Neurosci Res Volume: 89 Pages: 718-728
  • Peer Reviewed
• [Journal Article] In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice (2011)
  • Author(s): Liu N, Shang J, Tian FF, Nishi H, Abe K
  • Journal Title: Brain Res Volume: 1,397 Pages: 66-75
  • DOI: 10.1016/j.brainres.2011.04.038
  • NAID: 120005359110
  • Peer Reviewed
• [Journal Article] Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion (2011)
  • Author(s): Tanaka N, Ikeda Y, Ohta Y, Deguchi K, Tian F, Shang J, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1,370 Pages: 246-253
  • DOI: 10.1016/j.brainres.2010.11.010
  • Peer Reviewed
• [Journal Article] Expansion of Intronic GGCCTG Hexanucleotide Repeat in NOP56 Causes a Type of Spinocerebellar Ataxia (SCA36) Accompanied by Motor Neuron Involvement (2011)
  • Author(s): Hatasu Kobayashi, Koji Abe, Tohru Matsuura, Yoshio Ikeda, Toshiaki Hitomi, Yuji Akechi, Toshiyuki Habu, Wangyang Liu, Hiroko Okuda, Akio Koizumi
  • Journal Title: Am J Hum Genet Volume: 89(1) Issue: 1 Pages: 121-130
  • DOI: 10.1016/j.ajhg.2011.05.015
  • Peer Reviewed
• [Journal Article] Comparisons of acoustic function in SCA31 and other forms of ataxias (2011)
  • Author(s): Ikeda Y, Nagai M, Kurata T, Yamashita T, Ohta Y, Nagotani S, Deguchi K, Takehisa Y, Shiro Y, Matsuura T, Abe K
  • Journal Title: Neurol Res Volume: 33 Issue: 4 Pages: 427-732
  • DOI: 10.1179/1743132810y.0000000011
  • Peer Reviewed
• [Journal Article] Atorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-α (2011)
  • Author(s): Kozuki M, Kurata T, Miyazaki K, Morimoto K, Ohta Y, Ikeda Y, Abe K
  • Journal Title: Brain Res Volume: 1,388 Pages: 32-38
  • Peer Reviewed
• [Journal Article] Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice : protection by atorvastatin and pitavastatin (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Morimoto N, Ohta Y, Ikeda Y, Abe K
  • Journal Title: Neuroscience Volume: 197 Pages: 358-368
  • DOI: 10.1016/j.neuroscience.2011.09.030
  • Peer Reviewed
• [Journal Article] PSP as Distinguished from CBD, MSA-P and PD by Clinical and Imaging Differences at an Early Stage (2011)
  • Author(s): Kurata T, Kametaka S, Ohta Y, Morimoto N, Deguchi S, Deguchi K, Ikeda Y, Takao Y, Obta T, Manabe Y, Sato S, Abe K
  • Journal Title: Internal Medicine Volume: 50 Issue: 22 Pages: 2775-2781
  • DOI: 10.2169/internalmedicine.50.5954
  • NAID: 130001288665
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Panin VL, Mormoto N, Ohta Y, Nagai M, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1,371 Pages: 161-170
  • DOI: 10.1016/j.brainres.2010.11.067
  • Peer Reviewed
• [Journal Article] Correlation of cerebral spinal fluid pH and HCO3- with disease progression in ALS (2011)
  • Author(s): Morimoto K, Nagai M, Obta Y, Miyazaki K, Kurata T, Morimoto M, Murakami T, Takehisa Y, Ikeda Y, Kamiya T, Abe K
  • Journal Title: J Neurol Sci Volume: 37 Issue: 1-2 Pages: 74-78
  • DOI: 10.1016/j.jns.2011.05.013
  • Peer Reviewed
• [Journal Article] Differential clinical features in a pair of monozygotic twins with dentatorubropallidoluysian atrophy (2011)
  • Author(s): Sato K, Yunoki T, Morimoto N, Nagotani S, Deguchi K, Takehisa Y, Ikeda Y, Matsuura T, Abe K, Yamamoto Y
  • Journal Title: Eur J Neurol Volume: 18 Issue: 8 Pages: e100-e101
  • DOI: 10.1111/j.1468-1331.2011.03427.x
  • Peer Reviewed
• [Journal Article] In Vivo Imaging of Autophagy in a Mouse Stroke Model (2010)
  • Author(s): Tian F, Deguchi K, Yamashita T, Ohta Y, Morimoto N, Shang J, Zhang X, Liu N, Ikeda Y, Matsuura T, and Abe K
  • Journal Title: Autophagy Volume: 6 Pages: 1107-1114
  • NAID: 120005232491
  • Peer Reviewed
• [Journal Article] Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain (2010)
  • Author(s): Kawai H, Yamashita T, Ohta Y, Deguchi K, Nagotani S, Zhang X, Ikeda Y, Matsuura T, and Abe K
  • Journal Title: J Cerebral Blood Flow & Metabolism Volume: 30 Pages: 1487-1493
  • Peer Reviewed
• [Journal Article] In vivo optical imaging of early-stage apoptosis in mouse brain after transient cerebral ischemia (2010)
  • Author(s): Liu N, Deguchi K, Shang J, Zhang X, Tian F, Yamashita T, Ohta Y, Ikeda Y, Matsuura T, Abe K
  • Journal Title: J Neurosci Res Volume: 88 Pages: 3488-3497
  • Peer Reviewed
• [Journal Article] Mutations of optineurin in amyotrophic lateral sclerosis (2010)
  • Author(s): Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Kawakami H, et al
  • Journal Title: Nature Volume: 465 Pages: 223-226
  • Peer Reviewed
• [Journal Article] Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene (2010)
  • Author(s): Morimoto N, Nagai M, Miyazaki K, Ohta Y, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Asanuma M and Abe K
  • Journal Title: Neurosci Res Volume: 88 Pages: 1804-1811
  • Peer Reviewed
• [Journal Article] Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats (2010)
  • Author(s): Shang J, Deguchi K, Yamashita T, Ohta Y, Zhang H, Morimoto N, Liu N, Zhang X, Tian F, Matsuura T, Funakoshi H, Nakamura T and Abe K
  • Journal Title: J Neurosci Res Volume: 88 Pages: 2197-2206
  • Peer Reviewed
• [Journal Article] Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats (2010)
  • Author(s): Zhang X, Deguchi K, Yamashita T, Ohta Y, Shang J, Tian F, Liu N, Panin VL, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Brain Res Volume: 1343 Pages: 143-152
  • Peer Reviewed
• [Journal Article] In Vivo Imaging of Autophagy in a Mouse Stroke Model. (2010)
  • Author(s): Tian F., Deguchi K., Yamashita T., Ohta T., Morimoto N., Shang J., Zhang X., Liu N., Ikeda Y., Matsuura T., Abe K
  • Journal Title: Autophagy Volume: 6 Pages: 1107-1114
  • NAID: 120005232491
  • Peer Reviewed
• [Journal Article] Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain. (2010)
  • Author(s): Kawai H., Yamashita T., Ohta Y., Deguchi K., Nagotani S., Zhang K., Ikeda Y., Matsuura T., Abe K
  • Journal Title: J.Cerebral Blood Flow & Metabolism Volume: 30 Pages: 1487-1493
  • Peer Reviewed
• [Journal Article] A Case of familial anyloid polyneuropathy due to Phe33Val TTR with vitreous involvement as the initial manifestation. (2010)
  • Author(s): Kono S.Manabe Y.Tanaka T.Fujii D.Sakai Y.Narai H.Omori K.Ueda M.Ando Y.Abe K
  • Journal Title: Intern Med. Volume: 49 Pages: 1213-1216
  • Peer Reviewed
• [Journal Article] In vivo optical imaging of early-stage apoptosis in mouse brain after transient cerebral ischemia. (2010)
  • Author(s): Liu N, Deguchi K, Shang J, Zhang X, Tian F, Yamashita T, Ohta Y, Ikeda Y, Matsuura T, Abe X
  • Journal Title: J Neurosci Res. Volume: 88 Pages: 3488-3497
  • Peer Reviewed
• [Journal Article] Mutations of optineurin in amrotrophic lateral sclerosis. (2010)
  • Author(s): Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komura O, Matsuura S, Kobatake K, Morimoto N, Abe K, Kawakami H, et al
  • Journal Title: Nature Volume: 465 Pages: 223-226
  • Peer Reviewed
• [Journal Article] Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene. (2010)
  • Author(s): Morimoto N, Nagai M, Miyazaki K, Ohta Y, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Asanuma M, Abe K
  • Journal Title: J Neurosci Res Volume: 88 Pages: 1804-1811
  • Peer Reviewed
• [Journal Article] Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model. (2010)
  • Author(s): Seino Y, Kawarabayashi T, Wakasaya Y, Watanabe M, Takamura A, Yamamoto-Watanabe Y, Kurata T, Abe K, Ikeda M, Westaway D, Murakami T, Hyslop PS, Matsubara E, Shoji M
  • Journal Title: J Neurosci Res. Volume: 88 Pages: 3547-3554
  • Peer Reviewed
• [Journal Article] Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats. (2010)
  • Author(s): Shang J, Deguchi K, Yamashita T, Ohta Y, Zhang H, Morimoto N, Liu N, Zhang X, Tian F, Matsuura T, Funakoshi H, Nakamura T, Abe, K
  • Journal Title: J Neurosci Res. Volume: 88 Pages: 2197-2206
  • Peer Reviewed
• [Journal Article] Decline of human tactile angle discrimination in patients with mild cognitive impairment and Alzheimer's disease. (2010)
  • Author(s): Yang J, Ogasa T, Ohta Y, Abe K, Wu J
  • Journal Title: J Alzheimers Dis. Volume: 22 Pages: 225-234
  • Peer Reviewed
• [Journal Article] Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats. (2010)
  • Author(s): Zhang X, Deguchi K, Yamashita T, Ohta Y, Shang J, Tian F, Liu N, Panin VL, Ikeda Y, Matsuura T, Abe K
  • Journal Title: Brain Res. Volume: 1343 Pages: 143-152
  • Peer Reviewed
• [Presentation] アルツハイマー病モデルマウスを用いたスタチンによる認知機能への効果の検討 (2011)
  • Author(s): 倉田智子、宮崎一徳、上月美希、森本展年、池田佳生、松浦徹、阿部康二
  • Organizer: 第53回日本老年学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-16
• [Presentation] In Vivo Optical Imaging for Evaluating the Efficacy of Edaravone after Transient Cerebral Ischemia inMice (2011)
  • Author(s): Liu N, Shang J, Tian FF, Nishi H, Abe K
  • Organizer: 第23回日本脳循環代謝学会総会
  • Place of Presentation: Tokyo, Japan
• [Presentation] In vivo imaging of autophagy after cerebral ischemia in mice (2011)
  • Author(s): Kono S, Tian F, Deguchi K, Yamashita T, and Abe K
  • Organizer: The 5th Japanese-Korean Joint Stroke Conference
  • Place of Presentation: Gyeongju, Korea
• [Presentation] Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in model mice with Alzheimer's disease (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Morimoto N, Ohta Y, Abe K
  • Organizer: VASCog 2011
  • Place of Presentation: Lille, France
• [Presentation] Disruption of neurovascular unit relating to oxidative stress and mitochondrial deficit prior to motor neuron degeneration in ALS (2011)
  • Author(s): Miyazaki K, Ohta Y, Morimoto N, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 5th Biennial Meeting of Society for Free Radical Research-Asia
  • Place of Presentation: Kagoshima, Japan
• [Presentation] PROTECTIVE EFFECT OF MITOCHONDRIAL TRANSCROPTION FACTOR A OVEREXPRESSION IN ALS MODEL MICE (2011)
  • Author(s): Morimoto N, Miyazaki K, Kurata T, Ide T, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 5th Biennial Meeting of Society for Free Radical Research-Asia
  • Place of Presentation: Kagoshima, Japan
• [Presentation] In vivo optical imaging of early stage apoptosis in mice brain after transient cerebral ischemia (2011)
  • Author(s): Liu N, Deguchi K, Shang J, Zhang X, Tian FF, Yamashita T, Ohta Y, Ikeda Y, Matsuura T, Abe K
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: Kyoto, Japan
• [Presentation] In vivo optical imaging of early stage apoptosis in mice brain after transient cerebral ischemia (2011)
  • Author(s): Liu N, Deguchi K, Shang J, Zhang X, Tian FF, Yamashita T, Ohta Y, Ikeda Y, Matsuura T, Abe K
  • Organizer: 第36回日本脳卒中学会総会
  • Place of Presentation: 京都
• [Presentation] In Vivo Optical Imaging for Evaluating the Efficacy of Edaravone after Transient Cerebral Ischemia in Mice (2011)
  • Author(s): Liu N, Shang J, Tian FF, Nishi H, Abe K.
  • Organizer: 第23回日本脳循環代謝学会総会
  • Place of Presentation: 東京
• [Presentation] Disruption of neurovascular unit relating to oxidative stress and mitochondrial deficit prior to motor neuron degeneration in ALS (2011)
  • Author(s): Miyazaki K, Ohta Y, Morimoto K, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 5th Biennial Meeting of Society for Free Radical Research-Asia
  • Place of Presentation: Kagoshiia, Japan
• [Presentation] PROTECTIVE EFFECT OF MITOCHONDRIAL TRANSCROPTION FACTOR A OVEREXPRESSION IN ALS MODEL MICE (2011)
  • Author(s): Morimoto N, Miyazaki K, Kurata T, Ide T, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 5th Biennial Meeting of Society for Free Radical Research-Asia
  • Place of Presentation: Ragoshima, Japan
• [Presentation] Atorvastatin and pitavastatin reduce senile plaques and inflmmatory responses in model mice with Alzheimer's disease (2011)
  • Author(s): Kurata T, Miyazaki K, Kozuki M, Morimoto N, Ohta Y, Abe K
  • Organizer: VASCog 2011
  • Place of Presentation: Lille, France
• [Presentation] SCA31および他の小脳失調症における聴覚障害の検討 (2011)
  • Author(s): 池田佳生、倉田智子、山下徹、太田康之、出口章子、出口健太郎、武久康、城洋志彦、松浦徹、阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 岡山大学神経内科における遺伝子検査1,000件の臨床疫学的解析 (2011)
  • Author(s): 亀高さつき、池田佳生、阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] アルツハイマー病モデルマウスを用いたスタチンによる認知機能への影響についての研究 (2011)
  • Author(s): 倉田智子、宮崎一徳、上月美希、森本展年、池田佳生、松浦徹、阿部康二
  • Organizer: 第52回日本神経学会学術大会,
  • Place of Presentation: 名古屋
• [Presentation] ALSモデルマウス脊髄血管におけるneurovascular unitの異常 (2011)
  • Author(s): 宮崎一徳、太田康之、森本展年、倉田智子、池田佳生、松浦徹、阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] ALSモデルマウスの脊髄運動ニューロンにおけるα-synuclein、PINK1, DJ-1の発現について (2011)
  • Author(s): 森本展年, 宮崎一徳, 倉田智子, 池田佳生, 松浦徹, 阿部康二
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] ALSモデルマウス脊髄微小血管のIn vivoイメージング (2011)
  • Author(s): 宮崎一徳、正本和人、森本展年、太田康之、倉田智子、池田佳生、松浦徹、小畠隆行、菅野巌、阿部康二
  • Organizer: 第6回分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸
• [Presentation] タッチパネル式簡易認知症スクリーニング検査を用いたALS患者認知機能の検討 (2011)
  • Author(s): 森本展年、佐藤恒太、倉田智子、池田佳生、松浦徹、阿部康二
  • Organizer: 第30回日本認知症学会学術集会
  • Place of Presentation: 東京
• [Presentation] Disruption of neurovascular unit prior to motor neuron degeneration in ALS model mice (2011)
  • Author(s): Miyazaki K, Kurata T, Kawai H, Ohta Y, Morimoto N, Ikeda Y, Matsuura T, Abe K
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 進行性核上性麻痺と大脳皮質基底核変性症における臨床・画像的検討 (2010)
  • Author(s): 倉田智子、森本展年、高尾芳樹、大田泰正、真邊泰宏、池田佳生、松浦徹、阿部康二
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 愛知
  • Year and Date: 2010-11-05
• [Presentation] Induction of alpha-synuclein, PINK1, DJ-1 in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene (2010)
  • Author(s): Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: 7th Annual Meeting of ASMRM and 10th J-mit
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain (2010)
  • Author(s): Kawai H, Yamashita T, Ohta Y, Deguchi K, Nagotani S, Zhang X, Ikeda Y, Matsuura T, and Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto, Japan
• [Presentation] Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats (2010)
  • Author(s): Zhang X, Deguchi K, Yamashita T, Ohta Y, Shang J, Tian F, Liu N, Panin VL, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Functio
  • Place of Presentation: Kyoto, Japan
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, and Abe K
  • Organizer: 6th International Symposium on NEUROPROTECTION AND NEUROREPAIR 2010
  • Place of Presentation: Rostock, Germany
• [Presentation] Intrathecal Injection of EGF and FGF2 Promotes Proliferation of Neural Precursor Cells in the Spinal Cords of ALS Model Mice (2010)
  • Author(s): Ohta Y, Tian F, Nagai M, Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T and Abe K
  • Organizer: The 3rd Pan Pacific Symposium on Stem Cells Research
  • Place of Presentation: Taichung, Taiwan
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction. (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, Abe K
  • Organizer: 6th International Symposium on NEUROPROTECTION AND NEUROREPAIR 2010
  • Place of Presentation: Rostock, Germany
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunae infarction. (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto X, Abe K
  • Organizer: Brain Ischemia and Stroke 2010
  • Place of Presentation: Rome, Italy
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction. (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, Abe K
  • Organizer: 7th World STROKE CONGRESS
  • Place of Presentation: Seoul, Korea
• [Presentation] Effect of a free radical scavenger, edaravone, on motor palsy of acute lacunar infarction (2010)
  • Author(s): Omote Y, Ohta Y, Fukushima T, Takamatsu K, Ota T, Goto K, Abe K
  • Organizer: The 1st world Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] Tridermal tumorigenesis of induced pluripotent stem cells transplanted in ischemic brain. (2010)
  • Author(s): Kawai H, Yamashita T, Ohta Y, Deguchi K, Nagotani S, Zhang X, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] Intrathecal Injection of EGF and FGF2 Promotes Proliferation of Neural Precursor Cells in the Spinal Cords of ALS Model Mice. (2010)
  • Author(s): Ohta Y, Tian F, Nagai M, Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 3rd Pan Pacific Symposium on Stem Cells Research
  • Place of Presentation: Taichung, Taiwan
• [Presentation] Induction of alpha-synuclein, PINK1, DJ-1 in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene. (2010)
  • Author(s): Morimoto N, Miyazaki K, Kurata T, Ikeda Y, Matsuura T, Abe K
  • Organizer: 7th Annual Meeting of ASMRM and 10th J-mit
  • Place of Presentation: Fukuoka
• [Presentation] Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats. (2010)
  • Author(s): Zhang X, Deguehi K, Yamashita T, Ohta Y, Shang J, Tian F, Liu N, Panin VL, Ikeda Y, Matsuura T, Abe, K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] Metabolic syndrome is a risk factor for acute cerebral infarction in younger elderly Japanese population. (2010)
  • Author(s): Takamiya M, Ohta Y, Takeo Y, Harada K, Takao T, Abe K
  • Organizer: 7th World Stroke Congress
  • Place of Presentation: Seoul, Korea
• [Presentation] Metabolic syndrome is a risk factor for acute cerebral infarction in younger elderly Japanese Population. (2010)
  • Author(s): Takamiya M, Ohta Y, Takeo Y, Harada K, Takao T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] In vivo capillary imaging of spinal anterior horn in ALS model mice. (2010)
  • Author(s): Miyazaki K, Masamoto K, Morimoto N, Ohta Y, Kurata T, Ikeda Y, Matsuura T, Obata T, Kanno I, Abe K
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto
• [Presentation] Disruption of neurovascular unit Prior to motor neuron degeneration in ALS. (2010)
  • Author(s): Miyazaki K, Ohta Y, Morimoto N, Kurata T, Takehisa Y, Ikeda Y, Matsuura T, Abe K
  • Organizer: The 1st World Forum on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Kyoto
• [Presentation] TAT-FNK蛋白髄腔内投与によるALSモデルマウスへの蛋白治療の開発 (2010)
  • Author(s): 太田康之、永井真貴子、森本展年、宮崎一徳、武久康、倉田智子、池田佳生、松浦徹、麻生貞光、太田成男、阿部康二
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 進行性核上性麻痺と純粋無動症における臨床画像的検討 (2010)
  • Author(s): 倉田智子、宮崎一徳、森本展年、太田康之、瓦林毅、高尾芳樹、大田泰正、針谷康夫、真邊泰宏、池田佳生、松浦徹、東海林幹夫、阿部康二
  • Organizer: 第34回日本神経心理学会
  • Place of Presentation: 京都
• [Presentation] 運動失調症の治療開発研究への応用をめざした上肢協調運動障害の数量化測定装置の開発 (2010)
  • Author(s): 池田佳生、辻徳生、折戸謙介、松浦徹、石井抱、阿部康二
  • Organizer: 第28回日本神経治療学会総会
  • Place of Presentation: 横浜
• [Presentation] 運動神経のエイジングを示すALSモデルマウス脊髄前角の再生能力評価 (2010)
  • Author(s): 宮崎一徳、永井真貴子、森本展年、倉田智子、太田康之、武久康、池田佳生、松浦徹、阿部康二
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] 酸化ストレストと関連しているALSモデルマウス腰髄におけるNogo-AとそのレセプターであるNgRの変化 (2010)
  • Author(s): 宮崎一徳、永井真貴子、森木展年、倉田智子、太田康之、武久康、池田佳生、松浦徹、阿部康二
  • Organizer: 第63回日本酸化ストレス学会
  • Place of Presentation: 横浜
• [Presentation] ALSモデルマウス脊髄血管におけるneurovascular unitの異常 (2010)
  • Author(s): 宮崎一徳, 太田康之, 森本展年, 倉田智子, 池田佳生, 松浦徹, 阿部康二
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
• [Remarks] 岡山大学神経内科ホームページ
  • URL: http://www.okayama-u.ac.jp/user/med/shinkeinaika