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Development of drug delivery system for central nervous system disease using with temperature control devise

Research Project

Project/Area Number 22659261
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionYamaguchi University

Principal Investigator

SUZUKI Michiyasu  山口大学, 大学院・医学系研究科, 教授 (80196873)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,060,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords血液脳関門 / ニューロモデュレーションデバイス / 脳温 / ニューロモデュレーション
Research Abstract

Drug delivery system(DDS) through blood brain barrier(BBB) promises to enhance the effectiveness of medicine for nervous system diseases such as epilepsy and malignant brain tumors. In order to develop the DDS system, control of BBB permeability of molecules by alteration of temperature was analyzed. Tight junction of artificial BBB made from mouse endothelial cell was temporary opened at 15 degrees centigrade. And claudin5, one of the major structural proteins of the tight junction decreased the amount of expression at 15 degrees. Evans blue administered to a rat vein leaked to the brain surface when it was cooled. The increased permeability was reversible by the temperature control. Indocyanine green administered intravenously to an epilepsy patient appeared to the cooled area of brain surface at the surgery of temporal lobectomy. These results lead that the temperature control may modulate BBB permeability in a reversible fashion.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (22 results)

  • [Journal Article] Cooling of the Epileptic Focus Suppresses Seizures with Minimal Influence on Neurological Functions2012

    • Author(s)
      Fujii M, Inoue T, Nomura S, Maruta Y, He Y, Yamakawa T, Suzuki M
    • Journal Title

      Epilepsia53

      Pages: 485-493

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intra-operative monitoring of lower extremity motor-evoked potentials by direct cortical stimulation2012

    • Author(s)
      Maruta Y, Fujii M, Imoto H, Nomura S, Oka F, Goto H, Shirao S, Yoshikawa K, Yoneda H, Ideguchi M, Suehiro E, Koizumi H, Ishihara H, Kato S, Kajiwara K, Suzuki M
    • Journal Title

      Clin Neurophysiol. 2012[ Epub ahead of print]

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intra-operative monitoring of lower extremity motor-evoked potentials by direct cortical stimulation2012

    • Author(s)
      Maruta Y, Suzuki M, et.al
    • Journal Title

      Clin Neurophysiol

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of differences between brain temperature and core temperature(delta T) during mild hypothermia2011

    • Author(s)
      Suehiro E, Fujisawa H, Koizumi H, Nomura S, Kajiwara K, Fujii M, Suzuki M
    • Journal Title

      Neurol Med Chir

      Pages: 551-555

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions2011

    • Author(s)
      Fujii M, et al
    • Journal Title

      Epilepsia

      Volume: 53 Issue: 3 Pages: 489-493

    • DOI

      10.1111/j.1528-1167.2011.03388.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of differences between brain temperature and core temperature (delta T) during mild hypothermia in patients with diffuse axonal injury2011

    • Author(s)
      Suehiro E, Suzuki M, et al
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 51 Pages: 551-555

    • NAID

      10029338156

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳内埋め込み型大脳局所冷却装置によるてんかん治療法の開発2011

    • Author(s)
      藤井正美、鈴木倫保, 他
    • Journal Title

      てんかん治療研究振興財団研究年報

      Volume: 22 Pages: 91-98

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Application of focal cerebral cooling for the treatment of intractable epilepsy2010

    • Author(s)
      Fujii M, Fujioka H, Oku T, Tanaka N, Imoto H, Maruta Y, Nomura S, Kajiwara K, Saito T, Yamakawa T, Yamakawa T, Suzuki M
    • Journal Title

      Neurol Med Chir

      Pages: 839-844

    • NAID

      10030693779

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An implantable, focal brain cooling device suppresses nociceptive pain in rats2010

    • Author(s)
      Fujioka H, Fujii M, Koizumi H, Imoto H, Nomura S, Saito T, Yamakawa T, Suzuki M
    • Journal Title

      Neurosci Res

      Volume: 66 Pages: 402-405

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epileptiform discharges and neuronal plasticity in the acute peri-infarct cortex of rats2010

    • Author(s)
      Fujioka H, Kaneko H, Fujii M, Suzuki SS, Imoto H, Nomura S, Fujisawa H, Yamakawa T, Suzuki M
    • Journal Title

      Neurol Res

      Volume: 32 Pages: 666-669

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of focal cerebral cooling for the treatment of intractable epilepsy.2010

    • Author(s)
      Fujii M
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 50 Pages: 839-844

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An implantable, focal brain cooling device suppresses nociceptive pain in rats.2010

    • Author(s)
      Fujioka H
    • Journal Title

      Neurosci Res

      Volume: 66 Pages: 402-405

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epileptiform discharges and neuronal plasticity in the acute peri-infarct cortex of rats.2010

    • Author(s)
      Fujioka H
    • Journal Title

      Neurol Res

      Volume: 32 Pages: 666-669

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 局所脳冷却を用いた難治性てんかん治療装置の開発と臨床応用の実現に向けた医工連携2012

    • Author(s)
      藤井正美、鈴木倫保, 他
    • Organizer
      日本てんかん外科学会
    • Place of Presentation
      東京ステーションコンファレンス、東京(シンポジウム)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 局所脳冷却によるてんかん発作抑制のための至適冷却温度についての検討2012

    • Author(s)
      井上貴雄、鈴木倫保, 他
    • Organizer
      日本てんかん外科学会
    • Place of Presentation
      東京ステーションコンファレンス、東京(シンポジウム)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳冷却プローブを用いた術中脳機能マッピング法の確立2011

    • Author(s)
      藤井正美、鈴木倫保, 他
    • Organizer
      第9回日本Awake Surgery研究会
    • Place of Presentation
      日石横浜ホール、横浜市
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cooling of the Epileptic Focus Suppresses Seizures with Minimal Influence on Neurological Functions. American Epilepsy Society2011

    • Author(s)
      Fujii M, Inoue T, Suzuki M
    • Organizer
      Annual Meeting
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling-A review of our past atudies-2011

    • Author(s)
      Fujii M, Inoue T, Suzuki M, Tokiwa T, Yamakawa T
    • Organizer
      IEEE SMC
    • Place of Presentation
      Anchorage(Alaska), USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of a Focal Cerebral Cooling System for the Treatment of Intractable Epilepsy2011

    • Author(s)
      Takao Inoue, Masami Fujii, Michiyasu Suzuki
    • Organizer
      IEEE SMC
    • Place of Presentation
      Anchorage(Alaska), USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The effect of focal brain cooling on epileptic discharges in rats-Frequency analysis of electroencephalography-2011

    • Author(s)
      Hiroyuki Kida, Masami Fujii, Takao Inoue, Yeting He, Yuichi Maruta, Sadahiro Nomura, Kazuhiro Taniguchi, Takuya Ichikawa, Takashi Saito, Michiyasu Suzuki
    • Organizer
      IEEE SMC
    • Place of Presentation
      Anchorage(Alaska), USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibitory effects of focal brain cooling for motor cortical seizures in cats and nonhuman primates2011

    • Author(s)
      noue T, He Y, Fujii M, Fujioka H, Tokiwa T, Kida H, Imoto H, Maruta Y, Nomura S, Yamakawa T, Suzuki M
    • Organizer
      29th International Epilepsy Congress
    • Place of Presentation
      Rome, Italy
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling2011

    • Author(s)
      Fujii M, Inoue T, Imoto H, Tanaka N, Oku T, Maruta Y, Koizumi H, Nomura S, Owada Y, Saito T, Yamakawa T, Tokiwa T, Yamakawa T, Suzuki M
    • Organizer
      29th International Epilepsy Congress
    • Place of Presentation
      Rome, Italy
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Identification of epileptic focus with multi-channel near-infrared spectroscopic topography(optic topography).2011

    • Author(s)
      Maruta Y, Fujii M, Imoto H, Nomura S, Matsushige T, Ichiyama T, Yamakawa T, Suzuki M
    • Organizer
      29th International Epilepsy Congress
    • Place of Presentation
      Rome, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Cooling of the Epileptic Focus Suppresses Seizures with Minimal Influence on Neurological Functions2011

    • Author(s)
      Fujii M, Inoue T, Suzuki M, et al
    • Organizer
      American Epilepsy Society, Annual Meeting 2011
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 局所脳冷却を用いた術中脳機能マッピング法の確立2011

    • Author(s)
      藤井正美、鈴木倫保, 他
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      グランシップ、静岡市
    • Related Report
      2011 Annual Research Report
  • [Presentation] てんかん外科のこれまでの歩みと新たな展開-低浸襲治療法の開発-2011

    • Author(s)
      藤井正美、鈴木倫保, 他
    • Organizer
      日本脳神経外科学会第70回学術総会
    • Place of Presentation
      パシフィコ横浜、横浜市(シンポジウム)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling -A review of our past atudies-2011

    • Author(s)
      Fujii M, Inoue T, Suzuki M, et al
    • Organizer
      IEEE SMC 2011
    • Place of Presentation
      Anchorage (Alaska), USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of a Focal Cerebral Cooling System for the Treatment of Intractable Epilepsy2011

    • Author(s)
      Takao Inoue, Michiyasu Suzuki, et.al
    • Organizer
      IEEE SMC 2011
    • Place of Presentation
      Anchorage (Alaska), USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] The effect of focal brain cooling on epileptic discharges in rats-Frequency analysis of electroencephalography-2011

    • Author(s)
      Kida H, Suzuki M, et al
    • Organizer
      IEEE SMC 2011
    • Place of Presentation
      Anchorage (Alaska), USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of epileptic focus with multi-channel near-infrared spectroscopic topography (optic topography)2011

    • Author(s)
      Maruta Y, Suzuki M, et al
    • Organizer
      29th International Epilepsy Congress
    • Place of Presentation
      Rome, Italy
    • Related Report
      2011 Annual Research Report
  • [Presentation] Application of focal brain cooling for the treatment of intractable epilepsy2011

    • Author(s)
      Masami Fujii, Michiyasu Suzuki, et al
    • Organizer
      BITs 2nd Annual Congress of Neuro Talk-2011
    • Place of Presentation
      Dalian, China
    • Related Report
      2011 Annual Research Report
  • [Presentation] Alternative treatment of intractable epilepsy with focal brain cooling-A review of our past studies-2011

    • Author(s)
      Masami Fujii, Michiyasu Suzuki, et al
    • Organizer
      The 8th Scientific Meeting for the Asian Australasian Society of Stereotactic & Functional Neurosurgery
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2011 Annual Research Report
  • [Presentation] 術中脳機能マッピング用局所脳冷却プローブの開発2011

    • Author(s)
      藤井正美、鈴木倫保, 他
    • Organizer
      第20回脳神経外科手術と機器学会(CNTT)
    • Place of Presentation
      あわぎんホール、徳島市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 温度を用いた中枢神経疾患治療法2010

    • Author(s)
      鈴木倫保
    • Organizer
      第49回日本定位・機能神経外科学会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 埋め込み型脳局所冷却デバイスによるeloquent cortexに焦点を有するてんかん部分発作の抑制2010

    • Author(s)
      鈴木倫保
    • Organizer
      第33回日本てんかん外科学会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-01-22
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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