| Project/Area Number |
22659271
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
SAKAI Tadahiro 名古屋大学, 医学部附属病院, 病院講師 (60378198)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAIWA Hideki 名古屋大学, 医学部附属病院, 助教 (70566976)
HAMADA Takashi 名古屋大学, 医学部附属病院, 医員 (90566978)
YAMAMOTO Ryuichiro 名古屋大学, 医学部附属病院, 医員 (80586743)
光山 浩人 名古屋大学, 医学部附属病院, 特任助教 (80467282)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | 変形性関節症 / 軟骨細胞 / microRNA / ADAMTS4 / 変形性関節症(OA) / miRNA |
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| Research Abstract |
The pathological roles of microRNAs in osteoarthritis were analysed. We demonstrated that miR-125b is expressed in both normal and OA chondrocytes, with lower expression in OA chondrocytes than in normal chondrocytes. Furthermore, IL-1β-induced activation of ADAMTS4 was downregulated by overexpression of miR-125b in OA chondrocytes. Our results suggested that miR-125b plays a role in regulating the expression of ADAMTS4 in human chondrocytes and could be involved in the pathology of osteoarthritis.
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