| Project/Area Number |
22659273
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
OCHI Mitsuo 広島大学, 大学院・医歯薬学総合研究科, 教授 (70177244)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOSE Shouji 広島大学, 大学院・医歯薬学総合研究科, 准教授 (30304439)
KAMEI Naosuke 広島大学, 病院, 助教 (70444685)
NAKASA Tomoyuki 広島大学, 病院, 助教 (60467769)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 変形性関節症 / microRNA / 軟骨 / 滑膜 / biomarker / biomrker |
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| Research Abstract |
The purpose of this study is to examine the expression level of miRNA in serum and urine from osteoarthritis(OA) patients and determine its usefulness as biomarker of diagnosis of OA. In addition, secreted miRNA from mesenchymal stromal cells was injected into OA rat, and examine the therapeutic effect. In real time PCR analysis, there is no significant difference of expression of miRNA-146 and miRNA-223 between healthy subjects and OA patients. In animal model, there was no significant therapeutic effect of administration of secreted miRNA from mesenchymal stromal cell in OA rat.
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