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Development of a new anti-tumor therapy by occlusion of blood vessels

Research Project

Project/Area Number 22659274
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHiroshima University

Principal Investigator

DEIE Masataka  広島大学, 大学院・医歯薬保健学研究院, 教授 (30363063)

Co-Investigator(Kenkyū-buntansha) MORIYAMA Hideki  広島大学, 大学院・保健学研究科, 講師 (10438111)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,410,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords腫瘍 / 磁性 / 血管閉塞
Research Abstract

The purpose of this study is to develop a new anti-tumor therapy that blocks blood-flow to the tumor and necrotizes the tumor. First, we erected a method that couples microbeads with blood cells. Secondly, we glued a magnet to the surface of rat’s skull and injected the microbead - blood cell complexes into the rat’s internal carotid artery. As a result, we succeeded to occlude the rat’s middle cerebral artery. To lessen the damage to rats and to make the surgical technique simple, we conducted next experiment under another condition. The experiment showed that the middle cerebral artery of a rat was not occluded in that condition.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Effects of aging and exercise trainingon the histological and mechanical properties of articular structures in knee joints of male rat2012

    • Author(s)
      Moriyama H, Kanemura N, Brouns I, Pintelon I, Adriaensen D, Timmermans JP, Ozawa J, Kito N, Gomi T, Deie M
    • Journal Title

      Biogerontology

      Volume: 13(4) Pages: 369-81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synaptogenesis in the contralateral primary motor after focal brain infarction in rats2010

    • Author(s)
      Otani T, Maejima H, Tobimatsu Y, Shimada N, Toriyama M, Deie M.
    • Journal Title

      J. Phys. Ther. Sci

      Volume: 22(1) Pages: 69-74

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] The number of synapses in the primary motor cortex of contralesional hemisphere does not increase after cerebral infarction2011

    • Author(s)
      Otani T, Maejima H, Moriyama H, Shimada N, Shidahara H, Toriyama M, Orita N, Tobimatsu Y, Deie M
    • Organizer
      16th International WCPT Congress
    • Place of Presentation
      Amsterdam. Holland
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳梗塞ラットの非梗塞側一次運動野におけるシナプス可塑性について2010

    • Author(s)
      大谷拓哉,前島洋,武本秀徳,鳥山実,島田昇,飛松好子,出家正隆
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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