Development of a new anti-tumor therapy by occlusion of blood vessels
| Project/Area Number |
22659274
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
DEIE Masataka 広島大学, 大学院・医歯薬保健学研究院, 教授 (30363063)
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| Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Hideki 広島大学, 大学院・保健学研究科, 講師 (10438111)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,410,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 腫瘍 / 磁性 / 血管閉塞 |
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| Research Abstract |
The purpose of this study is to develop a new anti-tumor therapy that blocks blood-flow to the tumor and necrotizes the tumor. First, we erected a method that couples microbeads with blood cells. Secondly, we glued a magnet to the surface of rat’s skull and injected the microbead - blood cell complexes into the rat’s internal carotid artery. As a result, we succeeded to occlude the rat’s middle cerebral artery. To lessen the damage to rats and to make the surgical technique simple, we conducted next experiment under another condition. The experiment showed that the middle cerebral artery of a rat was not occluded in that condition.
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Report
(4 results)
Research Products
(4 results)
