Effects of chronic morphine treatment on angiogenesis
| Project/Area Number |
22659279
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 疼痛管理学 / モルヒネ塩酸塩 / 悪性腫瘍 / Lewis Lung Carcinoma / Alzet osmotic pump / C57BL/6 / オピオイド / 長期投与 / 血管新生 / 腫瘍増大 |
|---|
| Research Abstract |
Chronic treatment of morphine at low doses(0. 1-3 mg/kg/day) attenuated the growth of Lewis lung carcinoma(LLC) in C57BL/6 mice. However, higher dose(10mg/kg/day) of morphine does not affect LLC growth. These results suggest that effects of chronic morphine treatment on growth of LLC may be biphasic alteration.
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Report
(3 results)
Research Products
(21 results)
