Effects of chronic morphine treatment on angiogenesis

• Project/Area Number: 22659279
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Shinshu University
• Principal Investigator: KAWAMATA Mikito 信州大学, 医学部, 教授 (90315523)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 疼痛管理学 / モルヒネ塩酸塩 / 悪性腫瘍 / Lewis Lung Carcinoma / Alzet osmotic pump / C57BL/6 / オピオイド / 長期投与 / 血管新生 / 腫瘍増大

Research Abstract

Chronic treatment of morphine at low doses(0. 1-3 mg/kg/day) attenuated the growth of Lewis lung carcinoma(LLC) in C57BL/6 mice. However, higher dose(10mg/kg/day) of morphine does not affect LLC growth. These results suggest that effects of chronic morphine treatment on growth of LLC may be biphasic alteration.

Research Products

• [Journal Article] Changes in synaptic transmission of substantia gelatinosa neurons in a rat model of lumbar radicular pain revealed by in vivo patch-clamp recording (2011)
  • Author(s): Terashima Y, Kawamata M, Takebayashi T, Tanaka S, Tanimoto K, Yamashita T
  • Journal Title: Pain Volume: 152 Pages: 1024-32
  • NAID: 10031131118
  • Peer Reviewed
• [Journal Article] 癌性疼痛の発生機序 (2011)
  • Author(s): 川股知之, 山本克己, 布施谷仁志, 平林高暢, 坂本明之, 川真田樹人
  • Journal Title: 麻酔 Volume: 60 Pages: 1010-1017
  • Peer Reviewed
• [Journal Article] 下行性ノルアドレナリン神経による痛覚シナプス伝達の調節機構-青斑核からのin vivoパッチクランプ法- (2011)
  • Author(s): 杉山大介, 井本敬二, 川真田樹人, 古江秀昌
  • Journal Title: PAIN RESEARCH Volume: 26 Pages: 1-9
  • NAID: 10027914228
  • Peer Reviewed
• [Journal Article] Gastric tube insertion under visual control with the use of the Pentax-AWS^[○!R] (2011)
  • Author(s): Ikeno S, Nagano M, Tanaka S, Nishimura C, Kawamata T, Kawamata M
  • Journal Title: J Anesth Volume: 25 Pages: 475-476
  • NAID: 10029023422
  • Peer Reviewed
• [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices (2010)
  • Author(s): Narimatsu E, Niiya T, Kawamata T, Kawamata M, Yamakage M
  • Journal Title: Neurosci Res 2010 Volume: 68 Pages: 276-84
  • Peer Reviewed
• [Journal Article] Japanese Complex Regional Pain Syndrome Research Group (2010)
  • Author(s): Kawamata M
  • Journal Title: Pain Volume: 150 Pages: 243-9
  • Peer Reviewed
• [Journal Article] 術後譫妄の既往のある患者:十分な鎮痛と術中の脳血流維持で譫妄を予防する (2010)
  • Author(s): 井出進, 川真田樹人
  • Journal Title: LiSA Volume: 17 Pages: 902-904
• [Journal Article] 術後痛の発生メカニズム (2010)
  • Author(s): 川真田樹人
  • Journal Title: 麻酔 Volume: 59 Pages: 166-172
  • Peer Reviewed
• [Journal Article] 疼痛の発生機序 (2010)
  • Author(s): 川真田樹人
  • Journal Title: 産婦人科治療 Volume: 101 Pages: 105-110
  • Peer Reviewed
• [Journal Article] 術後痛のメカニズム (2010)
  • Author(s): 川真田樹人
  • Journal Title: Anesthesia 21th century 2010 Volume: 12 Pages: 46-52
  • Peer Reviewed
• [Journal Article] 炎症反応と疼痛 (2010)
  • Author(s): 川真田樹人, 杉山由紀
  • Journal Title: 臨床麻酔 Volume: 34 Pages: 1892-18
  • Peer Reviewed
• [Journal Article] Development of comprehensive diagnostic criteria for complex regional pain syndrome in the Japanese population. (2010)
  • Author(s): Kawamata M:Japanese Comple x Regional Pain Syndrome Research Group.
  • Journal Title: Pain. Volume: 150 Pages: 243-9
  • Peer Reviewed
• [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rathippocampal slices (2010)
  • Author(s): Narimatsu E, Niiya T, Kawama ta T, Kawamata M, Yamakage M
  • Journal Title: Neurosci Res Volume: 68 Pages: 276-84
  • Peer Reviewed
• [Journal Article] 麻酔 (2010)
  • Author(s): 川真田樹人
  • Journal Title: 術後痛の発生メカニズム Volume: 59
• [Journal Article] Gastric tube insertion under visual control with the use of the Pentax-AWS^<(R)>
  • Author(s): Ikeno S, Nagano M, Tanaka S, Nishimura C, Kawamata T, Kawamata M
  • Journal Title: J Anesth 2011 Volume: 25 Pages: 475-476
  • NAID: 10029023422
  • Peer Reviewed
• [Presentation] 遷延痛:急性痛は慢性痛に移行するか (2011)
  • Author(s): 川真田樹人
  • Organizer: 日本ペインクリニック学会第45回学術集会
  • Place of Presentation: 松山
  • Year and Date: 2011-07-23
• [Presentation] 遷延痛:急性痛は慢性痛に移行するか (2011)
  • Author(s): 川真田樹人
  • Organizer: 日本ペインクリニック学会
  • Place of Presentation: 松山(招待講演)
  • Year and Date: 2011-07-23
• [Presentation] 術後痛の発生メカニズム (2010)
  • Author(s): 川真田樹人
  • Organizer: 日本麻酔科学会第57回学術集会招請講演
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-03
• [Presentation] Successful in vivo patch clamp analysis of synaptic responses evoked in locus coeruleus neurons. (2010)
  • Author(s): Sugiyama D, Imoto K, Kawamata M, Fume H
  • Organizer: American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA.
• [Book] 局所麻酔薬.標準麻酔科学 (2011)
  • Author(s): 川真田樹人
  • Publisher: 医学書院
• [Book] 麻酔科トラブルシューティングA to Z. 高崎眞弓,河本昌志, 川真田樹人, 岡本浩嗣編 文光堂 (2010)
  • Author(s): 田中聡, 川真田樹人
  • Total Pages: 2
  • Publisher: 麻酔を始める直前モニターの調子が悪いことに気付いた