| Project/Area Number |
22659282
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
瀬川 一 京都大学, 医学研究科, 講師 (60263076)
正田 丈裕 京都大学, 医学研究科, 助教 (60335263)
辻川 洋 京都大学, 医学研究科, 助教 (20362501)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | グリア / 麻酔薬 / モルヒネ / 耐性 / エリスロポイエチン / 吸入麻酔薬 / オピオイド / 低酸素 / 人工心肺 / 鎮痛 |
|---|
| Research Abstract |
First, involvement of glial cells in the analgesic action of opioids was tested. Analysis of knockout mice and mutant mice revealed that tolerance to opioid analgesics is induced by microglial activation by a mechanism which does not involve the toll-like receptor 4. Next, it was demonstrated that hypoxia-or acute anemia-induced erythropoietin expression in the brain is inhibited by a volatile anesthetic, isoflurane. This phenomenon is suggested to be caused by inhibition of hypoxia-inducible factor 2 activity by isoflurane.
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