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Re-evaluation of the analgesic role in the general anesthesia

Research Project

Project/Area Number 22659284
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

MASHIMO Takashi  大阪大学, 医学系・研究科, 教授 (10110785)

Co-Investigator(Kenkyū-buntansha) NAKAE Aya  大阪大学, 大学院・医学系研究科, 特任准教授 (60379170)
SHIBATA Masahiko  大阪大学, 大学院・医学系研究科, 寄付講座教授 (50216016)
HAGIHIRA Satoshi  大阪大学, 医学部附属病院, 講師 (90243229)
橋本 亮太  大阪大学, 連合小児発達学研究科, 特任准教授(常勤) (10370983)
Co-Investigator(Renkei-kenkyūsha) HASHIMOTO Ryota  大阪大学, 大学院・分子統御機構研究センター, 准教授 (10370983)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,130,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords侵害受容 / 皮質脳波 / 統合失調症 / 疼痛感受性 / 注意課題 / 誘発電位 / 痛み / 情動 / 実験的痛み刺激 / 術後痛 / 全身麻酔
Research Abstract

There are many clinical reports about patients with schizophrenia who have less sensitivity to pain even in a severe clinical situation. However, it is unclear why these phenomenons occur. We clarified that patients with schizophrenia had different sensitivity to experimental pain ; less sensitive to experimental heat stimulation and more sensitive to experimental electrical stimulation. And we clarified that the patients with schizophrenia had different feeling to each experimental pain. Furthermore we clarified that patients with schizophrenia needed less analgesics after major abdominal surgery.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (11 results)

  • [Journal Article] 痛みのありか2011

    • Author(s)
      中江文、眞下節、長櫓巧
    • Journal Title

      PAIN RESEARCH

      Volume: 26(2) Pages: 73-73

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 情動と痛み2011

    • Author(s)
      中江文、眞下節
    • Journal Title

      PAIN RESEARCH

      Volume: 26(2) Pages: 119-119

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 痛みと情動2010

    • Author(s)
      中江文、眞下節
    • Journal Title

      Pain Research

      Volume: 25(4) Pages: 199-209

    • NAID

      10027755637

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 情動と痛み、コメディカル講演会:痛みとアロマ2011

    • Author(s)
      中江文、眞下節
    • Organizer
      第33回日本疼痛学会
    • Place of Presentation
      愛媛
    • Year and Date
      2011-07-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Pain in patients with schizophrenia-Difference between electrical and heat stimulation2011

    • Author(s)
      Aya Nakae, Ryota Hashimoto, Norihiro Sakai, Satoshi Hagihira, Mashiko Shibata, Takashi Mashimo
    • Organizer
      Euroanaesthesia 2011
    • Place of Presentation
      Amsterdam, Holland
    • Year and Date
      2011-06-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Pain in patients with schizophrenia- Difference between electrical and heat stimulation2011

    • Author(s)
      Aya Nakae, Ryota Hashimoto, Norihiro Sakai, Satoshi Hagihira, Mashiko Shibata, Takashi Mashimo
    • Organizer
      Euroanaestheisa 2011
    • Place of Presentation
      Amsterdam, Holland
    • Year and Date
      2011-06-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット後肢ホルマリンテストによる疼痛刺激は脳波変化の推移によって観察できる2011

    • Author(s)
      酒井規広、中井國博、中江文、萩平哲、眞下節
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 痛みとは何か~統合失調症患者研究を通した痛みの考察~2011

    • Author(s)
      中江文、橋本亮太、奥知子、酒井規広、柴田政彦、眞下節
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 痛みとは何か~統合失調症患者と健常者の痛みの感じ方の違い~2011

    • Author(s)
      中江文、橋本亮太、奥知子、福本素由己、大井一高、安田由華、山森英長、武田雅俊、柴田政彦、眞下節
    • Organizer
      第40回日本慢性疼痛学会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Pain sensitivity changes in patients with schizophrenia2010

    • Author(s)
      Aya Nakae, Ryota Hashimoto, Shogo Maeda, Tomoko Oku, Motoyuki Fukumoto, Kazutaka Ohi, Yuka Yasuda, Hidenaga Yamamori, Norihiro Sakai, Gaku Sakaue, Shoichi Ishigaki, Hiroko Kamide, Satoshi Hagihira, Masatoshi Takeda, Masahiko Shibata, Takashi Mashimo
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] The less sensitivity to pain in patients with schizophrenia in a postoperative period2010

    • Author(s)
      Norihiro Sakai, Aya Nakae, Ryota Hashimoto, Masaki Takashina, Takashi Mashimo
    • Organizer
      The 13th Asian Australasian Congress of Anesthesiologists
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2010-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] The less sensitivity to pain in patients with schizophrenia in a postoperative period2010

    • Author(s)
      Norihiro Sakai, Aya Nakae, Ryoto Hashimoto, Masaki Takashina, Takashi Mashimo
    • Organizer
      The 13th Asian Australasian Congress of Anesthesiologists
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症患者の痛みの感受性2010

    • Author(s)
      中江文、橋本亮太、前田尚悟、奥知子、安達友紀、福本素由己、大井一高、安田由華、山森英長、酒井規広、阪上学、石垣尚一、上出寛子、萩平哲、武田雅俊、柴田政彦、眞下節
    • Organizer
      平成22年度岡崎生理研研究会『痛みの病態生理と神経・分子機構』
    • Place of Presentation
      岡崎
    • Year and Date
      2010-02-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 統合失調症患者における痛覚感受性の変化2010

    • Author(s)
      中江文、橋本亮太、前田尚悟、奥知子、安達友紀、福本素由己、大井一高、安田由華、山森英長、酒井規広、阪上学、石垣尚一、上出寛子、萩平哲、武田雅俊、柴田政彦、眞下節
    • Organizer
      第3回日本運動器疼痛研究会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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