• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of new treatments of chemotherapy-induced peripheral neuropathy

Research Project

Project/Area Number 22659285
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionShinshu University (2011)
Sapporo Medical University (2010)

Principal Investigator

KAWAMATA Tomoyuki  信州大学, 医学部, 准教授 (80336388)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords化学療法 / 末梢神経障害 / 痛み / パクリタキセル / 後根神経節 / 外套細胞 / 疼痛 / 脊髄
Research Abstract

Paclitaxel treatment is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. Our results showed that satellite cell-derived L-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (16 results) Book (13 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy2011

    • Author(s)
      Kiya T, Kawamata T, Namiki A, Yamakage M
    • Journal Title

      Neuroscience

      Volume: 174 Pages: 190-199

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastric tube insertion under visual control with the use of the Pentax-AWS^<(R)>2011

    • Author(s)
      Ikeno S, Nagano M, Tanaka S, Nishimura C, Kawamata T, Kawamata M
    • Journal Title

      J Anesth 2011

      Volume: 25 Pages: 475-476

    • NAID

      10029023422

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastric tube insertion under visual control with the use of the Pentax-AWS^[○!R]2011

    • Author(s)
      Ikeno S, Nagano M, Tanaka S,Nishimura C, Kawamata T, Kawamata M
    • Journal Title

      J Anesth

      Volume: 25 Pages: 475-476

    • NAID

      10029023422

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of bone cancer pain by CB1 activation and TRPV1 inhibition2010

    • Author(s)
      Kawamata T, Niiyama Y, Yamamoto J, Furuse S
    • Journal Title

      J Anesth 2010

      Volume: 24 Pages: 328-332

    • NAID

      10027266825

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord2010

    • Author(s)
      Yanagisawa Y, Furue H, Kawamata T, Uta D, Yamamoto J, Furuse S, Katafuchi T, Imoto K, Iwamoto Y, Yoshimura M
    • Journal Title

      Mol Pain 2010

      Volume: 6 Pages: 38-38

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular signaling of pruritus induced by endothelin-1 in mice2010

    • Author(s)
      Liang J, Kawamata T, Ji W
    • Journal Title

      Exp Biol Med 2010

      Volume: 235 Pages: 1300-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices2010

    • Author(s)
      Narimatsu E, Niiya T, Kawamata T, Kawamata M, Yamakage M
    • Journal Title

      Neurosci Res

      Volume: 68 Pages: 276-84

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of bone cancer pain by CB1 activation and TRPV1 inhibition2010

    • Author(s)
      Kawamata T
    • Journal Title

      J Anesth

      Volume: 24 Pages: 328-332

    • NAID

      10027266825

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord2010

    • Author(s)
      Yanagisawa Y
    • Journal Title

      Mol Pain

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular signaling of pruritus induced by endothelin-1 in mice2010

    • Author(s)
      Liang J
    • Journal Title

      Exp Biol Med

      Volume: 235 Pages: 1300-1305

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices2010

    • Author(s)
      Narimatsu E
    • Journal Title

      Neurosci Res

      Volume: 68 Pages: 276-284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] aCGRP is involved in inflammation-but not incision-induced thermal hyperalgesia2011

    • Author(s)
      Ishida K, Kawamata T, Shindo T, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] aCGRP is involved in inflammation-but not incision-induced thermal hyperalgesia2011

    • Author(s)
      Ishida K, Kawamata T, Shindo T, Ishida T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Involvement of phopholipaseCb and TRPV1 in inflammation-induced thermal hyperalgesia2011

    • Author(s)
      Ide S, Kawamata T, Shimizu F, Mochidome M, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Behavioral characterization of a newly developed model of postoperative pain after laparotomy2011

    • Author(s)
      Tanaka H, Kawamata T, Sugiyama D, Ichino T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] A low concentration of levobupivacaine has a potent differential sensory blocking property2011

    • Author(s)
      Sakamoto A, Tanaka S, Kawamata T, Tsukahara Y, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] TRPV1 and TRPV2 are expressed in primary afferent neurons innervating bone marrow2011

    • Author(s)
      Yamamoto K. Kawamata T, Ishida K, Sakamoto A, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible involvement of monoaminergic control of motoneurons in mechanically compressed spinal cord injury-induced spasticity2011

    • Author(s)
      Mochiduki N, Kawamata T, Tanaka S, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of nail polish of different colors on SpHbdetermined by MASIMO Radical-72011

    • Author(s)
      Mochidome M, Kawamata T, Imai E, Urasawa M, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Relationship between differential distribution of blood flow to blocked or unblocked areas and the extent of the sensory block2011

    • Author(s)
      Imai E, Tanaka S, Kawamata T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of cardiac output measured by Three-demensional transesophageal echocardiography with that by continuous thermodilution2011

    • Author(s)
      Hishinuma N, Ide S, Tanaka S, Kawamata T, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨がん疼痛を科学する2010

    • Author(s)
      川股知之
    • Organizer
      第4回日本緩和医療薬学会年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 鎮痛補助薬2010

    • Author(s)
      川股知之
    • Organizer
      第48回日本癌治療学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gq-Coupled Receptors Sensitize TRPV1 through PLCB3 Activation in Peripheral Nociceptive Neurons2010

    • Author(s)
      Kawamata T
    • Organizer
      Annual Meeting of American Society of Anesthesi ologists
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] QX314 selectively reduces ongoing pain but not movement-evoked pain in a murine model of bone cancer pain2010

    • Author(s)
      Fuseya S, Kawamata T, Imai E, Urasawa S, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Analgesic Tolerance by Repeated Activation of Spinal Cannabinoid Receptor 1 in Bone Cancer Pain2010

    • Author(s)
      Kawamata T, Mochizuki N, Furuse S, Tanaka H, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Spinal NMDA Receptor Is Involved in Bone Cancer-Induced Ongoing Pain but Not Movement-Evoked Pain2010

    • Author(s)
      Kawamata T, Fuseya S, Furuse S, Yamamoto K, Kawamata M
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Final Research Report
  • [Book] 非定型頭痛. For Professional Anesthesiologists神経障害性疼痛.真下節編2011

    • Author(s)
      川股知之
    • Publisher
      克誠堂出版,東京
    • Related Report
      2011 Final Research Report
  • [Book] 悪心・嘔吐.支持・緩和薬物療法マスターがん治療の副作用対策.江口研二,相羽恵介,門田和気,高野利実編2011

    • Author(s)
      川股知之
    • Publisher
      株式会社メディカルビュー社
    • Related Report
      2011 Final Research Report
  • [Book] For Professional Anesthesiologists神経障害性疼痛2011

    • Author(s)
      川股知之
    • Publisher
      克誠堂出版
    • Related Report
      2011 Annual Research Report
  • [Book] 抗不整脈薬. For Professional Anesthesiologists癌性疼痛.花岡一雄編2010

    • Author(s)
      川股知之
    • Publisher
      東京,克誠堂出版
    • Related Report
      2011 Final Research Report
  • [Book] オピオイドローテーションとは.がん看護別冊今日からできる緩和ケア.小山冨美子,山下めぐみ,服部政治編2010

    • Author(s)
      高橋稔之,川股知之
    • Publisher
      東京,南江堂
    • Related Report
      2011 Final Research Report
  • [Book] がん性疼痛.ペインクリニック別冊がん疼痛管理に必要な知識.小川節郎編2010

    • Author(s)
      川股知之
    • Publisher
      東京,真興交易(株)医書出版部
    • Related Report
      2011 Final Research Report
  • [Book] 8節脊髄腔内i. t. PGF2投与モデル.慢性疼痛治療における有効な薬剤選定と治療薬開発のパラダイム2010

    • Author(s)
      川股知之
    • Publisher
      東京,技術情報協会
    • Related Report
      2011 Final Research Report
  • [Book] 9節腰部脊柱管狭窄モデル.慢性疼痛治療における有効な薬剤選定と治療薬開発のパラダイム2010

    • Author(s)
      川股知之
    • Publisher
      東京,技術情報協会
    • Related Report
      2011 Final Research Report
  • [Book] 第1部術前. IX章中枢・末梢神経系2010

    • Author(s)
      川股知之
    • Publisher
      東京,文光堂
    • Related Report
      2011 Final Research Report
  • [Book] For Professional Anesthesiologists癌性疹痛2010

    • Author(s)
      川股知之
    • Total Pages
      321
    • Publisher
      克誠堂出版
    • Related Report
      2010 Annual Research Report
  • [Book] がん疼痛管理に必要な知識2010

    • Author(s)
      川股知之
    • Total Pages
      239
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2010 Annual Research Report
  • [Book] 慢性疼痛治療における有効な薬剤選定と治療薬開発2010

    • Author(s)
      川股知之
    • Total Pages
      417
    • Publisher
      技術情報協会
    • Related Report
      2010 Annual Research Report
  • [Book] 麻酔科トラブルシューティングA to2010

    • Author(s)
      川股知之
    • Total Pages
      637
    • Publisher
      文光堂
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] L-セリンを含有する末梢神経障害の予防・治療剤2011

    • Inventor(s)
      川股知之,木谷友洋
    • Industrial Property Rights Holder
      札幌医科大学
    • Filing Date
      2011-03-04
    • Related Report
      2011 Final Research Report
    • Overseas

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi