Development of new treatments of chemotherapy-induced peripheral neuropathy

• Project/Area Number: 22659285
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Shinshu University (2011); Sapporo Medical University (2010)
• Principal Investigator: KAWAMATA Tomoyuki 信州大学, 医学部, 准教授 (80336388)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 化学療法 / 末梢神経障害 / 痛み / パクリタキセル / 後根神経節 / 外套細胞 / 疼痛 / 脊髄

Research Abstract

Paclitaxel treatment is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. Our results showed that satellite cell-derived L-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy.

Research Products

• [Journal Article] Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy (2011)
  • Author(s): Kiya T, Kawamata T, Namiki A, Yamakage M
  • Journal Title: Neuroscience Volume: 174 Pages: 190-199
  • Peer Reviewed
• [Journal Article] Gastric tube insertion under visual control with the use of the Pentax-AWS^<(R)> (2011)
  • Author(s): Ikeno S, Nagano M, Tanaka S, Nishimura C, Kawamata T, Kawamata M
  • Journal Title: J Anesth 2011 Volume: 25 Pages: 475-476
  • NAID: 10029023422
  • Peer Reviewed
• [Journal Article] Gastric tube insertion under visual control with the use of the Pentax-AWS^[○!R] (2011)
  • Author(s): Ikeno S, Nagano M, Tanaka S,Nishimura C, Kawamata T, Kawamata M
  • Journal Title: J Anesth Volume: 25 Pages: 475-476
  • NAID: 10029023422
  • Peer Reviewed
• [Journal Article] Reduction of bone cancer pain by CB1 activation and TRPV1 inhibition (2010)
  • Author(s): Kawamata T, Niiyama Y, Yamamoto J, Furuse S
  • Journal Title: J Anesth 2010 Volume: 24 Pages: 328-332
  • NAID: 10027266825
  • Peer Reviewed
• [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord (2010)
  • Author(s): Yanagisawa Y, Furue H, Kawamata T, Uta D, Yamamoto J, Furuse S, Katafuchi T, Imoto K, Iwamoto Y, Yoshimura M
  • Journal Title: Mol Pain 2010 Volume: 6 Pages: 38-38
  • Peer Reviewed
• [Journal Article] Molecular signaling of pruritus induced by endothelin-1 in mice (2010)
  • Author(s): Liang J, Kawamata T, Ji W
  • Journal Title: Exp Biol Med 2010 Volume: 235 Pages: 1300-5
  • Peer Reviewed
• [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices (2010)
  • Author(s): Narimatsu E, Niiya T, Kawamata T, Kawamata M, Yamakage M
  • Journal Title: Neurosci Res Volume: 68 Pages: 276-84
  • Peer Reviewed
• [Journal Article] Reduction of bone cancer pain by CB1 activation and TRPV1 inhibition (2010)
  • Author(s): Kawamata T
  • Journal Title: J Anesth Volume: 24 Pages: 328-332
  • NAID: 10027266825
  • Peer Reviewed
• [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord (2010)
  • Author(s): Yanagisawa Y
  • Journal Title: Mol Pain Volume: 6
  • Peer Reviewed
• [Journal Article] Molecular signaling of pruritus induced by endothelin-1 in mice (2010)
  • Author(s): Liang J
  • Journal Title: Exp Biol Med Volume: 235 Pages: 1300-1305
  • Peer Reviewed
• [Journal Article] Effects of atropine and pralidoxime on neuronal actions of paraoxon in rat hippocampal slices (2010)
  • Author(s): Narimatsu E
  • Journal Title: Neurosci Res Volume: 68 Pages: 276-284
  • Peer Reviewed
• [Presentation] aCGRP is involved in inflammation-but not incision-induced thermal hyperalgesia (2011)
  • Author(s): Ishida K, Kawamata T, Shindo T, Ishida T, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago
  • Year and Date: 2011-10-16
• [Presentation] aCGRP is involved in inflammation-but not incision-induced thermal hyperalgesia (2011)
  • Author(s): Ishida K, Kawamata T, Shindo T, Ishida T, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] Involvement of phopholipaseCb and TRPV1 in inflammation-induced thermal hyperalgesia (2011)
  • Author(s): Ide S, Kawamata T, Shimizu F, Mochidome M, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] Behavioral characterization of a newly developed model of postoperative pain after laparotomy (2011)
  • Author(s): Tanaka H, Kawamata T, Sugiyama D, Ichino T, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] A low concentration of levobupivacaine has a potent differential sensory blocking property (2011)
  • Author(s): Sakamoto A, Tanaka S, Kawamata T, Tsukahara Y, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] TRPV1 and TRPV2 are expressed in primary afferent neurons innervating bone marrow (2011)
  • Author(s): Yamamoto K. Kawamata T, Ishida K, Sakamoto A, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] Possible involvement of monoaminergic control of motoneurons in mechanically compressed spinal cord injury-induced spasticity (2011)
  • Author(s): Mochiduki N, Kawamata T, Tanaka S, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] Effects of nail polish of different colors on SpHbdetermined by MASIMO Radical-7 (2011)
  • Author(s): Mochidome M, Kawamata T, Imai E, Urasawa M, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] Relationship between differential distribution of blood flow to blocked or unblocked areas and the extent of the sensory block (2011)
  • Author(s): Imai E, Tanaka S, Kawamata T, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] Comparison of cardiac output measured by Three-demensional transesophageal echocardiography with that by continuous thermodilution (2011)
  • Author(s): Hishinuma N, Ide S, Tanaka S, Kawamata T, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: Chicago, USA
• [Presentation] 骨がん疼痛を科学する (2010)
  • Author(s): 川股知之
  • Organizer: 第4回日本緩和医療薬学会年会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-11-15
• [Presentation] 鎮痛補助薬 (2010)
  • Author(s): 川股知之
  • Organizer: 第48回日本癌治療学会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-30
• [Presentation] Gq-Coupled Receptors Sensitize TRPV1 through PLCB3 Activation in Peripheral Nociceptive Neurons (2010)
  • Author(s): Kawamata T
  • Organizer: Annual Meeting of American Society of Anesthesi ologists
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-10-16
• [Presentation] QX314 selectively reduces ongoing pain but not movement-evoked pain in a murine model of bone cancer pain (2010)
  • Author(s): Fuseya S, Kawamata T, Imai E, Urasawa S, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA
• [Presentation] Analgesic Tolerance by Repeated Activation of Spinal Cannabinoid Receptor 1 in Bone Cancer Pain (2010)
  • Author(s): Kawamata T, Mochizuki N, Furuse S, Tanaka H, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA
• [Presentation] Spinal NMDA Receptor Is Involved in Bone Cancer-Induced Ongoing Pain but Not Movement-Evoked Pain (2010)
  • Author(s): Kawamata T, Fuseya S, Furuse S, Yamamoto K, Kawamata M
  • Organizer: Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA
• [Book] 非定型頭痛. For Professional Anesthesiologists神経障害性疼痛.真下節編 (2011)
  • Author(s): 川股知之
  • Publisher: 克誠堂出版,東京
• [Book] 悪心・嘔吐.支持・緩和薬物療法マスターがん治療の副作用対策.江口研二,相羽恵介,門田和気,高野利実編 (2011)
  • Author(s): 川股知之
  • Publisher: 株式会社メディカルビュー社
• [Book] For Professional Anesthesiologists神経障害性疼痛 (2011)
  • Author(s): 川股知之
  • Publisher: 克誠堂出版
• [Book] 抗不整脈薬. For Professional Anesthesiologists癌性疼痛.花岡一雄編 (2010)
  • Author(s): 川股知之
  • Publisher: 東京,克誠堂出版
• [Book] オピオイドローテーションとは.がん看護別冊今日からできる緩和ケア.小山冨美子,山下めぐみ,服部政治編 (2010)
  • Author(s): 高橋稔之,川股知之
  • Publisher: 東京,南江堂
• [Book] がん性疼痛.ペインクリニック別冊がん疼痛管理に必要な知識.小川節郎編 (2010)
  • Author(s): 川股知之
  • Publisher: 東京,真興交易(株)医書出版部
• [Book] 8節脊髄腔内i. t. PGF2投与モデル.慢性疼痛治療における有効な薬剤選定と治療薬開発のパラダイム (2010)
  • Author(s): 川股知之
  • Publisher: 東京,技術情報協会
• [Book] 9節腰部脊柱管狭窄モデル.慢性疼痛治療における有効な薬剤選定と治療薬開発のパラダイム (2010)
  • Author(s): 川股知之
  • Publisher: 東京,技術情報協会
• [Book] 第1部術前. IX章中枢・末梢神経系 (2010)
  • Author(s): 川股知之
  • Publisher: 東京,文光堂
• [Book] For Professional Anesthesiologists癌性疹痛 (2010)
  • Author(s): 川股知之
  • Total Pages: 321
  • Publisher: 克誠堂出版
• [Book] がん疼痛管理に必要な知識 (2010)
  • Author(s): 川股知之
  • Total Pages: 239
  • Publisher: 真興交易(株)医書出版部
• [Book] 慢性疼痛治療における有効な薬剤選定と治療薬開発 (2010)
  • Author(s): 川股知之
  • Total Pages: 417
  • Publisher: 技術情報協会
• [Book] 麻酔科トラブルシューティングA to (2010)
  • Author(s): 川股知之
  • Total Pages: 637
  • Publisher: 文光堂
• [Patent(Industrial Property Rights)] L-セリンを含有する末梢神経障害の予防・治療剤 (2011)
  • Inventor(s): 川股知之,木谷友洋
  • Industrial Property Rights Holder: 札幌医科大学
  • Filing Date: 2011-03-04
  • Overseas