Establishment of diagnosis of renal and prostate cancer by analysis of the expression of microRNAs in blood

• Project/Area Number: 22659286
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: The University of Tokyo
• Principal Investigator: OBA Shigeyoshi 東京大学, 医学部附属病院, 助教 (80361492)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 腫瘍学 / microRNA / 癌 / 腎臓 / microarray / 血液

Research Abstract

We compared the expression of microRNAs in blood of normal control and renal carcinoma patients. The result is that 20 microRNAs were predominantly dysregulated in renal carcinoma patients. Among 20 microRNAs, 9 microRNAs were more predominantly dysregulated. By scoring the expression of 9 microRNAs, we could establish new diagnosis method with over 70%-80% sensitivity and specificity. Then we compared the expression of 9 microRNAs between new 3 normal control and 3 renal carcinoma patients. One microRNA tent to decrease in renal cell carcinoma patients.