| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Research Abstract |
In this research, we hypothesized that microRNAs were secreted in urine from prostate cancer cells, and that the microRNAs, which are specific for prostate cancer, could be stably extracted from urine samples, and could be useful for new biomarkers. We performed microRNA array using whole urine samples, but none was significantly different in expression. We found that the microRNA expression in culture medium could reflect its expression in cell lines. But the expressions of some microRNAs, which have already been known to be associated with prostate cancer, were different in culture medium, cell lines, and urine samples. We are trying to establish the proper method, by which we can precisely estimate the expression of microRNAs in urine samples, and we are planning to explore new microRNAs associated with prostate cancer.
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