Mechanisms of abnormal organogenesis and histogenesis of the kidney and ureter and development of the embryonic treatment
| Project/Area Number |
22659289
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Shimane University |
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Principal Investigator |
OTANI Hiroki 島根大学, 医学部, 教授 (20160533)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Akihiro 島根大学, 医学部, 助教 (70346378)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,370,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | 奇形学 / 尿管 / 腎臓 / 子宮外発生法 / マウス胚 / 収斂伸長 / Wnt5a / interkinetic nuclear migration |
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| Research Abstract |
We have clarified that cell rearrangements including convergent extension are involved in elongation of the ureter and ‘elevation’ of the kidney, and observed interkinetic nuclear migration-like nuclear movement in the proliferating epithelial cells of the ureter. The exo-utero manipulation/development system, a method to modify the organogenesis and histogenesis of organs including the ureter, has been improved by echo-guidance and other refinements for the more accurately targeted injection. Although we could not obtain conclusive results in the ureter-related experiments, we could successfully modify the histogenesis in the experiments of the musculoskeletal system.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Expression pattern of Galectin 4in rat placentation.2012
Author(s)
Arikawa T,Simamura E,Shimada H,NishiN,TatsunoT,IshigakiY,TomosugiN,YamashiroC,HataT,TakegamiT,MogamiH,YamaguchiK,NakamuraT,OtaniH,HattaT,ShojiH.
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Journal Title
Placenta
Volume: 33
Issue: 10
Pages: 885-887
DOI
Related Report
Peer Reviewed
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