The development of novel molecular therapeutic agents targeting ion transporters for the treatment of hormone refractory prostate cancer

Research Project

Project/Area Number	22659290
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Urology
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	MIKI Tsuneharu 京都府立医科大学, 医学研究科, 教授 (10243239)
Co-Investigator(Kenkyū-buntansha)	KAWAUCHI Akihiro 京都府立医科大学, 医学研究科, 准教授 (90240952) HONGO Fumiya 京都府立医科大学, 医学研究科, 助教 (80291798) KIMURA Yasunori 京都府立医科大学, 医学研究科, 助教 (20398374) MARUNAKA Yoshinori 京都府立医科大学, 医学研究科, 教授 (00127036)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,350,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥450,000) Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords	前立腺癌 / 細胞増殖 / クロライドイオン / KCC / N-ethylmaleimide
Research Abstract	We showed that activation of K^+/Cl^-cotransporter(KCC) led the intracellular Cl^-concentration of androgen-independent prostate cancer cells and decreased proliferation of the cells. We produced various derivatives of N-ethylmaleimide(NEM), KCC activator, and investigated the effect of them on proliferation of androgen-independent prostate cancer cells. The specific derivative for the cells induced the antitumor effect in mouse model of prostate cancer.