Can we produce ovarian stem cells by gene expression of Yamanaka factors to ovarian cancer cell lines?
| Project/Area Number |
22659300
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
KOSAKA Kenzo 京都大学, 医学研究科, 講師 (90359828)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Noriomi 京都大学, 医学研究科, 助教 (20452336)
HAMANISHI Jyunzo 京都大学, 医学研究科, 助教 (80378736)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 卵巣癌 / 幹細胞 / iPS / エピジェネティクス / 癌幹細胞 / マイクロアレイ |
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| Research Abstract |
Ovarian cancer is characterized by its early metastasis and peritoneal dissemination. Their prognosis is very bad among other gynecological malignancies. So, we need to clarify the mechanism of pathogenesis and metastasis. We found the expression of OCT4, which is one of Yamanaka factors. We are aimed to detect changes of ovarian cancer cell lines by gene expression of Yamanaka factors. We also present the possibility of the important role of TGF-b pathway for the metastasis of ovarian cancer.
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Report
(3 results)
Research Products
(32 results)
