Effect of gain-of-function mutation in ASIC on vestibular and auditory function
| Project/Area Number |
22659307
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka University |
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Principal Investigator |
SHIMADA Shoichi 大阪大学, 大学院・医学系研究科, 教授 (20216063)
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| Co-Investigator(Kenkyū-buntansha) |
YAGITA Kazuhiro 京都府立医科大学, 医学研究科, 教授 (90324920)
ISHIDA Yusuke 大阪大学, 大学院・医学系研究科, 講師 (30381809)
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| Co-Investigator(Renkei-kenkyūsha) |
UGAWA Shinya 名古屋市立大学, 大学院・医学研究科, 教授 (20326135)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 内耳 / イオンチャネル / 点変異 / トランスジェニックマウス / 有毛細胞 / トーンスジェニックマウス |
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| Research Abstract |
Members of acid sensing ion channel(ASIC) gene family are widely expressed in the central and peripheral nervous system and sensory organs including inner ear. A substitution of glycine 430 of ASIC2a by phenylalanine produced gain-of-function channel. Transfection of the mutant channel induced cell death. Transgenic rats expressing G430F-ASIC2a resulted in balance and gait disturbances.
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Report
(3 results)
Research Products
(9 results)
