Mouse models of Autoimmune hearing loss generated by a transgenic approach and its implication
| Project/Area Number |
22659309
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
OGAWA Kaoru 慶應義塾大学, 医学部, 教授 (00169179)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJIOKA Masato 慶應義塾大学, 医学部, 共同研究員 (70398626)
KANZAKI Sho 慶應義塾大学, 医学部, 講師 (50286556)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
|
|---|
| Keywords | 耳科学 / トランスレーショナルリサーチ / 自己免疫 / 難聴 / 免疫学 / 聴覚医学 / 国際情報研究 |
|---|
| Research Abstract |
Autoimmune hearing loss models were established by generating a transgenic mouse (Math-HA) that specifically expresses HA antigen in the inner ear hair cells. By an adoptive transfer of lymphocytes derived from CL4mice, the mice suffered hearing loss at h
|
Report
(3 results)
Research Products
(19 results)
