Molecular mechanism of gender gap in dry eye disease
| Project/Area Number |
22659312
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
TSUBOTA Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | ドライアイ / シェーグレン症候群 / ムスカリン性アセチルコリン受容体 / 涙腺 |
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| Research Abstract |
Sjogren's syndrome is a systemic autoimmune disease in which immune cells attack and destroy the exocrine glands that produce tears and saliva(resulting dry eyes and mouth). The incidence of Sjogren's syndrome significantly increases in middle-aged or older women. The pathogenesis is unknown. The elucidation of the molecular mechanism and early establishment of new therapeutic approach are expected. Therefore, we examined the role of mAchRs in tear secretion by using various mAchR(M1-M5) genes knockout(mAchRKO) mice. We revealed that M1/M3 AchRs are key molecules for tear secretion. In addition, tear secretion were changed by sex hormone treatments.
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Report
(3 results)
Research Products
(12 results)
