| Project/Area Number |
22659319
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
TACHI Masahiro 東北大学, 大学院・医学系研究科, 教授 (50312004)
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| Co-Investigator(Kenkyū-buntansha) |
KODAMA Tetsuya 東北大学, 大学院・医学系研究科, 教授 (40271986)
IMAI Yoshimichi 東北大学, 大学院・医学系研究科, 准教授 (80323012)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | レッグリングハウゼン病 / NFI遺伝子 / ナノバブル / 遺伝子導入 / 遺伝子治療 / レッグレイングハウゼン病 / レックリングハウゼン氏病 / NF1遺伝 / 遺伝導入 / インターフェロンβ / インターフェロンγ |
|---|
| Research Abstract |
Initially the aim of this study was development of a gene therapy of von Recklinghausen's disease. However, because it became clear that integration of NF-1 gene into the vector was difficult, we have changed the target to Malignant peripheral nerve sheath tumor (MPNST), complicating disease of von Recklinghausen's disease.
We have observed a marked decrease in number of cells by transfection of IFN-α and IFN-γ gene into cells delived from MPNST.
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