| Project/Area Number |
22659323
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OOHASHI Toshitaka 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (50194262)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | リンパ管 / リンパ浮腫 / リポソーム / 生体イメージング / 蛍光色素 / LYVE1 / モノクローナル抗体 / リンパ管造影 |
|---|
| Research Abstract |
Current research aimed to establish a new active targeting liposome system for diagnosis of lymphedema, by targeting it to the lymphatic endothelial cell markers. Specific binding of the molecular targeting liposome to cultured lymphatic endothelial cells in vitro and visualization of lymphatic vessels in normal mice were demonstrated. However, we could not establish the measuring system in rat lymphedema model. As for its related technique, we could develop a new liposome encapsulated with colloidal gold which enables both light-and electron-microscopic analysis.
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