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Development of Imaging Diagnosis for Lymphedema

Research Project

Project/Area Number 22659323
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Plastic surgery
Research InstitutionOkayama University

Principal Investigator

NINOMIYA Yoshifumi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (70126241)

Co-Investigator(Kenkyū-buntansha) OOHASHI Toshitaka  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (50194262)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsリンパ管 / リンパ浮腫 / リポソーム / 生体イメージング / 蛍光色素 / LYVE1 / モノクローナル抗体 / リンパ管造影
Research Abstract

Current research aimed to establish a new active targeting liposome system for diagnosis of lymphedema, by targeting it to the lymphatic endothelial cell markers. Specific binding of the molecular targeting liposome to cultured lymphatic endothelial cells in vitro and visualization of lymphatic vessels in normal mice were demonstrated. However, we could not establish the measuring system in rat lymphedema model. As for its related technique, we could develop a new liposome encapsulated with colloidal gold which enables both light-and electron-microscopic analysis.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (19 results)

All 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 9 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Mechanical stress enhances COL2Al expression on chromatin by indducing SOX9 nuclear translocalization in inner meniscus cells2012

    • Author(s)
      Kanazawa T, et al
    • Journal Title

      J Orthop Res

      Volume: 30(3) Issue: 3 Pages: 468-474

    • DOI

      10.1002/jor.21528

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bral2 is indispensable for the proper localization of brevican and the structural integrity of the perineuronal net in the brain stem and cerebellum2011

    • Author(s)
      Bekku Y, Saito M, Moser M, Fuchigami M, Maehara A, Nakayama M, Kusachi S, Ninomiya Y, Oohashi T
    • Journal Title

      J Comp Neurol

      Volume: 520 Issue: 8 Pages: 1721-1736

    • DOI

      10.1002/cne.23009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of an active targeting liposome encapsulated with high-density colloidal gold for transmission electron microscopy2011

    • Author(s)
      Minematsu H, Otani T, Oohashi T, Hirai M, Oie K, Igarashi K, Ohtsuka A
    • Journal Title

      J Electron Microsc

      Volume: 60(1) Pages: 95-99

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clonal overgrowth of esophageal smooth muscle cells in diffuse leiomyomatosis-Alport syndrome caused by partial deletion in COL4A5 and COL4A6 genes2011

    • Author(s)
      Oohashi T, Naito I, Ueki Y, Yamatsuji T, Permpoon R, Tanaka N, Naomoto Y, Ninomiya Y
    • Journal Title

      Matrix Biol

      Volume: 30(1) Pages: 3-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 関節軟骨のバイオイメージング2011

    • Author(s)
      大橋俊孝, 西田圭一郎
    • Journal Title

      Clinical Calcium

      Volume: 21(6) Pages: 100-106

    • Related Report
      2011 Final Research Report
  • [Journal Article] Olmesartan reduces arterial stiffness and serum adipocyte fatty acid-binding protein in hypertensive patients2011

    • Author(s)
      Miyoshi T, ら
    • Journal Title

      Heart Vessels

      Volume: 26 Issue: 4 Pages: 408-413

    • DOI

      10.1007/s00380-010-0060-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane2011

    • Author(s)
      Kinnunen AI, ら
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 10 Pages: 7755-7764

    • DOI

      10.1074/jbc.m110.166132

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an active targeting liposome encapsulated with high-density colloidal gold for transmission electron microscopy.2011

    • Author(s)
      Minematsu, et al.
    • Journal Title

      J Electron Microsc (Tokyo)

      Volume: 60(9) Pages: 95-99

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo.2011

    • Author(s)
      Cilek ZM, et al.
    • Journal Title

      Cell Biol Int

      Volume: 35(1) Pages: 1-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bral : its role in diffusion barrier formation and conduction velocity in theCNS2010

    • Author(s)
      Bekku Y, Vargova L, Goto Y, Vorisek I, Dmytrenko L, Narasaki M, Ohtsuka A, Fassler R, Ninomiya Y, Sykova E, Oohashi T
    • Journal Title

      J Neurosci

      Volume: 30(8) Pages: 3113-23

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 軟骨組織のバイオイメージング2010

    • Author(s)
      大橋俊孝
    • Journal Title

      臨床整形外科

      Volume: 45(5) Pages: 454-457

    • Related Report
      2011 Final Research Report
  • [Presentation] 炎症標的化金コロイド内包リポソームのリウマチ関節炎症部位への集積2012

    • Author(s)
      前原亜美
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] 炎症標的化金コロイド内包リポソームのリウマチ関節炎症部位への集積2012

    • Author(s)
      前原亜美, ら
    • Organizer
      日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 炎症標的化金コロイド内包リポソームのリウマチ関節炎症部位への集積2011

    • Author(s)
      古谷満寿美
    • Organizer
      第43回日本結合組織学会,第58回マトリックス研究会
    • Place of Presentation
      大分
    • Related Report
      2011 Final Research Report
  • [Presentation] 炎症標的化リポソームのリウマチ関節炎症部位への集積2010

    • Author(s)
      大橋俊孝
    • Organizer
      病理学会カンファレンス-電子顕微鏡観察-
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] シアリルルイスX糖鎖結合リポソームのリウマチ関節炎症部位への集積についての電子顕微鏡的検討2010

    • Author(s)
      松本衣未
    • Organizer
      第51回日本生化学会中国.四国支部例会
    • Place of Presentation
      山口
    • Related Report
      2011 Final Research Report
  • [Presentation] ADAMTS1のin vitroでのリンパ管新生阻害効果2010

    • Author(s)
      稲垣純子, ほか
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田市
    • Related Report
      2010 Annual Research Report
  • [Presentation] ADAMTS1プロモーターは急性低酸素状態の内皮細胞選択的に遺伝子発現を誘導する2010

    • Author(s)
      Mehmet Zeynel Cilek, ほか
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田市
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://mbb-okayama.sakura.ne.jp/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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