A genomic screening for the genes upregulated by DNA demethylation in human keloidderived

Research Project

Project/Area Number	22659324
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Plastic surgery
Research Institution	Jichi Medical University
Principal Investigator	SUNAGA Ataru 自治医科大学, 医学部, 助教 (00406117)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,110,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥210,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywords	ケロイド / マイクロアレイ / エピジェネティクス
Research Abstract	We carried out a genome-wide screen for the genes upregulated by DNA demethylation in human keloid-derived fibroblasts and showed that 25 genes with promoter CpG island were upregulated 16-fold or more. These results suggest epigenetic modification is involed in keloid pathogenesis and could be a new theraputic target for keloid.

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(3 results)