A genomic screening for the genes upregulated by DNA demethylation in human keloidderived
| Project/Area Number |
22659324
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
SUNAGA Ataru 自治医科大学, 医学部, 助教 (00406117)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,110,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | ケロイド / マイクロアレイ / エピジェネティクス |
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| Research Abstract |
We carried out a genome-wide screen for the genes upregulated by DNA demethylation in human keloid-derived fibroblasts and showed that 25 genes with promoter CpG island were upregulated 16-fold or more.
These results suggest epigenetic modification is involed in keloid pathogenesis and could be a new theraputic target for keloid.
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Report
(3 results)
Research Products
(4 results)
