Functional relation of stress response in blood cells and brain after hypoxia
| Project/Area Number |
22659325
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Yamagata University |
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Principal Investigator |
GOTO Kaoru 山形大学, 医学部, 教授 (30234975)
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| Co-Investigator(Kenkyū-buntansha) |
ISEKI Ken 山形大学, 医学部, 准教授 (70332921)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 低酸素脳症 / 生体ストレス / 脂質代謝酵素 / 脂質代謝 / KOマウス / 血球細胞 |
|---|
| Research Abstract |
Biological stress determines recovery from emergency conditions, such as accidents and surgery and affects intracellular signal transduction. Diacylglycerol kinase (DGK) is an enzyme that metabolizes the second messenger DG in phosphoinositide turnover. Recent studies have indicated an involvement of diacylglycerol kinase (DGK) in various diseases such as cancer, diabetes, inflammation and stroke. In the present study we performed an experiment at the organismal level using hypoxic chamber stress (oxygen concentration 5%). After 3 days of transient hypoxic stress, we found that DGKζ was translocated from the nucleus to the cytoplasm. These results provide an evidence that nucleo-cytoplasmic translocation of DGKζ may be an index of early phase of apoptosis.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry2012
Author(s)
Okada M, Hozumi Y, Tanaka T, Suzuki Y, Yanagida M, Araki Y, Evangelisti C, Yagisawa H, Topham MK, Martelli AM, Goto K.
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Journal Title
Cell Signal
Volume: 24
Issue: 8
Pages: 1573-82
DOI
Related Report
Peer Reviewed
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[Journal Article] NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices2012
Author(s)
Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fujii S, Goto K.
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Journal Title
Histochem CellBiol
Volume: 137
Issue: 4
Pages: 499-511
DOI
Related Report
Peer Reviewed
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[Journal Article] NAP Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins2011
Author(s)
Okada M, Hozumi Y, Ichimura T, Tanaka T, Hasegawa H, Yamamoto M, Takahashi N, Iseki K, Yagisawa H, Shinkawa T, Isobe T, Goto K.
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Journal Title
Exp Cell Res
Volume: 317
Issue: 20
Pages: 2853-63
DOI
Related Report
Peer Reviewed
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