| Project/Area Number |
22659325
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Yamagata University |
|---|
Principal Investigator |
GOTO Kaoru 山形大学, 医学部, 教授 (30234975)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISEKI Ken 山形大学, 医学部, 准教授 (70332921)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 低酸素脳症 / 生体ストレス / 脂質代謝酵素 / 脂質代謝 / KOマウス / 血球細胞 |
|---|
| Research Abstract |
Biological stress determines recovery from emergency conditions, such as accidents and surgery and affects intracellular signal transduction. Diacylglycerol kinase (DGK) is an enzyme that metabolizes the second messenger DG in phosphoinositide turnover. Recent studies have indicated an involvement of diacylglycerol kinase (DGK) in various diseases such as cancer, diabetes, inflammation and stroke. In the present study we performed an experiment at the organismal level using hypoxic chamber stress (oxygen concentration 5%). After 3 days of transient hypoxic stress, we found that DGKζ was translocated from the nucleus to the cytoplasm. These results provide an evidence that nucleo-cytoplasmic translocation of DGKζ may be an index of early phase of apoptosis.
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