| Project/Area Number |
22659333
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松尾 美樹 鹿児島大学, 医歯学総合研究科口腔微生物学分野 (20527048)
大貝 悠一 鹿児島大学, 医歯学総合研究科口腔微生物学分野 (40511259)
神原 賢治 鹿児島大学, 医歯学総合研究科口腔微生物学分野 (60305141)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 細菌 / 歯学 / サイトカイン / 細菌感染 / ケモカイン / 黄色ブドウ球菌 / 口腔レンサ球菌 / 歯肉上皮細胞 / 免疫抑制 / 炎症 / サイトイン / 抗菌性ペプチド / 抗菌力 / 口腔内細菌 / 上皮細胞 |
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| Research Abstract |
The purpose of this research is to demonstrate the new function of cytokines. We investigated the antibacterial activity of cytokines, the cytokine affinity to bacterial cells and the effect of cytokine treatment on bacterial attachment to mammal cells. We found that MIP3alpha and IL8, positive charged peptides, were able to bind bacterial cells, and had weak antibacterial effect, while biding of cytokines to bacterial cells had no effect on the bacterial attachment to mammal cells. In conclusion, it is suggested that some cytokines binds to bacteria causing to modulate the immune responses
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